1) Maize lethal necrosis disease (MLND) poses a threat to food security in Eastern Africa by affecting maize, a key crop. 2) The disease has spread to several countries in the region since 2012. 3) A regional response is proposed to manage and control MLND through a three-pronged approach of preparedness, immediate responses, and long-term resilience building and mitigation strategies. This would help reduce the disease's impact on food security and limit its spread.