The document provides information about the history and development of the periodic table. It discusses how ancient Greeks like Empedocles believed that all matter was composed of four basic elements. It then outlines key contributions by Robert Boyle, Humphry Davy, Dobereiner, Newlands and Mendeleev to developing patterns in the properties of elements and early periodic table arrangements. Finally, it mentions Henry Moseley's discovery that atomic number, not mass, is the fundamental property determining an element's position in the periodic table.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
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Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
2. You should know the following by the end of
today’s class…
• History of the idea of elements including
the contributions of the Greeks, Boyle and
Davy and Moseley
• Symbols of elements 1–36.
• History of the periodic table, including the
contributions of Dobereiner and Newlands
• The differences between the first Periodic
table and the modern table
11. In particular Empedocles 490 – 435 BCE,
had the idea that there were four basic
building blocks (elements) from which
everything was made:
earth,
fire,
water
and air
The Ancient Greeks
IDEA THAT MATTER IS COMPOSED OF ELEMENTS AND THAT
DIFFERENT ELEMENTS COMBINE TO MAKE NEW THINGS!
12. The Ancient Greeks
Democritus
Around 2500 years ago
Piece of matter
Split or break up
Eventually I end up with something which
cannot be broken up – called an element
13. Robert Boyle
Robert Boyle
17th Century
Irish scientist,
Robert Boyle,
later defined what
an element was:
An element is a substance that cannot
be broken down into any simpler substance
Definition
14. Humphrey Davy
• Davy was an English chemist who started out
his research examining the medicinal effect of
various gases
18. Naming the elements
• After a planet ….mercury, uranium
• European mythological figures….Titanium after
the Titans
• After its colour…. Gold
• After a physical property… Bromine= bad smell
• After a country…. francium = France
• After yourself….?
• After a scientist… Es = Einsteinium
20. Recap
• What is an element?
• What did the ancient Greeks think
materials were made of?
• Who was Robert Boyle?
• What contribution did Davy make to the
knowledge of the elements?
21.
22. Arrangement of the elements
•All of the known elements
of today are arranged on
….The Periodic Table of
Elements
24. Looking for a pattern in the
elements
• In the 1800s over 50
elements had been
discovered and more
were being found!
• Chemists wanted to
find if there was any
pattern to the elements
Date of Discovery
25. Johann Dobereiner
Dobereiner
1829 – His theory of triads
He noticed that certain
elements in groups of 3
had similar physical &
chemical properties with
the atomic weight of the
middle element being
halfway between the other
two.
He called such a group of
elements a triad.
What contribution did Dobereiner make to the systematic arrangement of the elements? (6)
2005 Q. 4 (d) (6)
26. Newlands -1864
Newland arranged all of the known
elements in order of increasing
atomic weight and he noticed the
chemical and physical properties of
the elements repeated with every 8th
element.
Higher level only
27. John Newlands
Newlands
Law of octaves
H Li Be B C N O
F Na Mg Al Si P S
He arranged the elements in order of
increasing atomic weight
Every 8th known element had similar
physical & chemical properties.
John Newlands
What contribution did Newlands make to the systematic arrangement of the elements known to him? (6)
2006 Q. 4 (f) (6)
28. Newlands Octaves
• The problem is that after Calcium the pattern starts to
break down.
• Although Newland had the right idea, some of the
elements hadn’t been discovered yet and this caused
elements to be forced into the wrong group!
Higher level only
29. Mendeleev and the periodic
table
Mendeleev created the first periodic table by grouping
together elements in a certain way.
30. Dmitri Mendeleev
Mendeleev
1869 – He drew up the first
periodic table of the known
elements of his time by arranging
the elements in order of
increasing atomic weight.
He noticed repeating patterns
which lead him to make very
accurate predictions about
undiscovered elements.
33. The differences in Mendeleev’s table and
the modern periodic table
1. Mendeleev’s table was arranged in order of
increasing atomic mass. Modern table is
arranged in order of increasing atomic
number.
2. In Mendeleev’s table the noble gases are
not included in the modern Table they are.
3. There are gaps in Medeleev’s table but
there are none in the modern periodic table
as they have been discovered..
State two ways in which Mendeleev’s periodic table of the elements differs from that of Moseley.
2003 Q. 4 (i) (6)
34.
35.
36. What have you learnt about..
Dobereiner
Newlands
Mendeleev
Octaves
Triads
37. Henry Moseley
Moseley
1913 – Henry Moseley discovered
that the positive charge in the
nucleus of an atom of any element is
of a definite amount.
These units of positive charge
became known as protons. The
periodic table is now arranged in
order of increasing atomic number.
The atomic number of and element is the number of protons
in the nucleus of an atom of that element
Definition
2008 Q. 4 (b) (6)
What contribution did Henry Moseley, the scientist shown in the photograph, make to the systematic arrangement
of the elements in the periodic table?
43. Group 1 – The Alkali Metals
2. They all float on water
1. They are all shiny
metals which are easily
cut with a knife.
3. They are all extremely
reactive and have to be
stored in oil to prevent
them from reacting
with the oxygen in the
air.
44. Demonstration – The reaction of
the alkali metals with water
1 – The reaction of lithium with water
2 – The reaction of sodium with water
3 – The reaction of potassium with
water
45. Why do the alkali metals increase in
reactivity as you go down the group?
As you go down the group the atomic radius
increases and the outermost electron is much
further from the nucleus and is under less of an
effect so that element is more reactive. This
outer electron is also protected from the nucleus
by an inner ‘screening effect’ of the inner
electrons.
Lithium Sodium
Potassium
6
2006 Q. 5 (b) (9)
Explain, in terms of the structures of the atoms, the trend in reactivity down Group I (the alkali metal group) of the
periodic table.
46. Balanced Equations
Li
Lithium
½
+ H2O H2 + LiOH
Water Hydrogen
Lithium
Hydroxide
2 2 2
Na
Sodium
½
+ H2O H2 + NaOH
Water Hydrogen
Sodium
Hydroxide
2 2 2
K
Potassium
½
+ H2O H2 + KOH
Water Hydrogen
Potassium
Hydroxide
2 2 2
47. Check if you have learnt..
• What group 1 in the Table is called?
• How many electrons are in the outer shell
of group 1 elements?
• Some properties of group 1 metals?
• What happens when they are reacted with
water?
• What is the reactivity trend as you go
down the group?
48. In today’s class
• We will look at the properties of the rest of
the groups in the Periodic table.
49. Group 2 – The earth alkali metals
Includes the following elements:
Beryllium (Be)
Magnesium (Mg)
Calcium (Ca) and others!
•They are all metals
•All of the elements in group one have two electrons in their outermost
shell!
•They are reactive- They have a tendency when reacting with outer
elements to lose these outer electrons and form ionic compounds
•They react less vigorously with water to produce hydrogen
50. Group 2 – The Alkaline Earth Metals
2. They are reactive but
not as reactive as the
alkali metals
1. They all have 2
electrons in their outer
shell
51. Groups 3 -11 The d block metals
They are all metals and are
usually brightly coloured and
act as catalysts for chemical
reactions
Includes the following
elements:
Scandium (Sc)
Titanium (Ti)
Vanadium (V)
Chromium (Cr)
Manganese (Mn)
Iron (Fe)
Cobalt (Co)
Nickel (Ni)
Copper (Co)
Zinc (Zn) and others!
55. Group 16
•All have 6 electrons on their outermost shell!
•All of the group are metals except for Polonium which is a metal
56. Group 17 - The Halogens
•They are non metals
•All of the elements in group one
have seven electrons in their
outermost shell!
•They are reactive - They have a
tendency when reacting with
outer compounds to gain one
electron
58. Group 18 - The Noble gases
They are all non metals
They are all odourless
and colourless gases
They are very
unreactive as they have
an outer shell full of
electrons, which makes
them chemically stable