15 bird species in India are listed as critically endangered, including the Bengal florican with a population of under 1,000, the Lesser florican which is threatened by hunting and habitat loss, and the Great Indian bustard with an estimated 250 individuals remaining threatened by hunting and habitat degradation. Other critically endangered species mentioned are the Sociable lapwing, Baer's pochard, Siberian crane, spoon-billed sandpiper, White-bellied heron, Jerdon's courser, Forest owlet, Pink-headed duck, Red-headed vulture, White-backed vulture, Slender-billed vulture, and the Himalayan quail which is feared extinct.
Background on snow leopard and research activities for the Biosphere Expeditions snow leopard conservation project in the Altai Republic, Central Asia (www.biosphere-expeditions.org/altai).
Background on snow leopard and research activities for the Biosphere Expeditions snow leopard conservation project in the Altai Republic, Central Asia (www.biosphere-expeditions.org/altai).
The chinkara or Indian gazelleis a species of gazelle found in South asia. Characterized by a sandy,yellowish and red coloured fur with a pale white ventral region.
8 Most Endangered Animals - All About Wildlifepgpoonamgirn
Endangered means to be under threat or near extinction. When a species/animal is endangered it means that they are disappearing fast or have a very small population - not large enough to survive. Read more about this in the PPT.
A species of plant or animal that is in immediate danger of becoming extinct and needs protection to survive.
Preservation is to save and maintain the wild animals against injury or destruction as well as keeping them safe and undisturbed from private or public use
Endangered species in world and as well as in Pakistan,reasons and causes of their endangerment ,methods of conservation of endangered species ,step taken at international level for their control most famous is act law formulated on 1973
Dudhwa National Park, Uttar Pradesh , Indiakonkon98
Dudhwa National Park is situated in Uttar Pradesh.
The Information and pictures in the presentation are taken from various sources on the internet.
It was a school project of mine.
Any issues with the presentation can be talked out and if necessary will remove the presentation with no further delay if the case is genuine.
There might be changes in the Facts and figures since this presentation was made in the year 2014.
No animals were harmed during the making of this ppt.
This presentation is for information and project purpose only.
These are the 7 main families of rays with every species of stingray (over 200) categorized accordingly to teach others about these beautiful, majestic creatures.
GREAT INDIAN BUSTARD IS ENDANGERED... Its time to take action.
AANYA PUNATARfrom EUROSCHOOL,AIROLIr makes a small attempt to bring awareness by this presentation.
Wants to know more about greater one horned Rhino (Rhinoceros unicornis)? Here, find a bit about this pachyderm. It’s a Quiz arranged for the students and common public of rhino bearing countries.
The chinkara or Indian gazelleis a species of gazelle found in South asia. Characterized by a sandy,yellowish and red coloured fur with a pale white ventral region.
8 Most Endangered Animals - All About Wildlifepgpoonamgirn
Endangered means to be under threat or near extinction. When a species/animal is endangered it means that they are disappearing fast or have a very small population - not large enough to survive. Read more about this in the PPT.
A species of plant or animal that is in immediate danger of becoming extinct and needs protection to survive.
Preservation is to save and maintain the wild animals against injury or destruction as well as keeping them safe and undisturbed from private or public use
Endangered species in world and as well as in Pakistan,reasons and causes of their endangerment ,methods of conservation of endangered species ,step taken at international level for their control most famous is act law formulated on 1973
Dudhwa National Park, Uttar Pradesh , Indiakonkon98
Dudhwa National Park is situated in Uttar Pradesh.
The Information and pictures in the presentation are taken from various sources on the internet.
It was a school project of mine.
Any issues with the presentation can be talked out and if necessary will remove the presentation with no further delay if the case is genuine.
There might be changes in the Facts and figures since this presentation was made in the year 2014.
No animals were harmed during the making of this ppt.
This presentation is for information and project purpose only.
These are the 7 main families of rays with every species of stingray (over 200) categorized accordingly to teach others about these beautiful, majestic creatures.
GREAT INDIAN BUSTARD IS ENDANGERED... Its time to take action.
AANYA PUNATARfrom EUROSCHOOL,AIROLIr makes a small attempt to bring awareness by this presentation.
Wants to know more about greater one horned Rhino (Rhinoceros unicornis)? Here, find a bit about this pachyderm. It’s a Quiz arranged for the students and common public of rhino bearing countries.
Mammals of Pakistan
if you need any kind of help feel free to contact me
Haseeb Kamran | Mphil Wildlife and Ecology GIS & Remote Sensing Lab | University of Veterinary and Animal Sciences, Lahore (Ravi Campus).
00923486311164
Discover the fascinating world of wildlife sanctuaries in India with this comprehensive guide. Learn about their history, purpose, and the incredible biodiversity found within. Gain a deeper appreciation for the importance of conservation and discover how you can get involved in protecting these precious habitats.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
15 bird species in india in critically endangered list
1. 15 bird species in India in critically endangered list
Bengal
florican
This threatened species is now
almostextinct; probably fewer
than 1,000 and perhaps as few
as 500 adult birds are still alive
Lesser
florican
found in tall grasslands. It is
threatened both by hunting and
habitat degradation. The only
similar species is the bengal
florican
Great
indian
bustard
once common on the dry plains
of the indian subcontinent, as
few as 250 individuals were
estimated, s critically
endangered by hunting and loss
of its habitat, which consists of
large expanses of dry grassland
and scrub.
Sociable
lapwing
North-west india, very rapid
population decline for poorly
understood reasons.
2. 15 bird species in India in critically endangered list
Baer's
pochard
Siberian
crane
spoon-
billed
sandpiper
White-
bellied
heron
. This heron is mostly solitary
and is found on undisturbed
riverside or wetland habitats.
The global population has
declined and the species is
threatened by disturbance and
habitat degradation.
3. 15 bird species in India in critically endangered list
Jerdon's
courser
Found locally in india in
the eastern ghats of andhra
pradesh. It has an extremely
limited geographical range being
known from the godaveri river
valley. This bird was known only
from a few historical records
and was thought to be extinct
until its rediscovery in 1986.
Being a rare bird, nothing is
known yet about its behaviour
and nesting habits.
Population estimates for the
bird range from between 50 and
249.
Forest
owlet
t is endemic to the forests of
central India. it was considered
extinct[2] until it was
rediscovered 113 years later in
1997
Pink-
headed
duck
This duck formerly occurred in
eastern India, Bangladesh and
northern Myanmar,[32] but is
now probably extinct. It was
always rare
4. 15 bird species in India in critically endangered list
Red-
headed
vulture
Mainly found in the Indian
Subcontinent, The widespread
use of NSAID Diclofenac in
veterinary medicine in India has
caused its population to collapse
in recent years.
White-
backed
Vulture
Sometimes it is called African
White-backed Vulture to
distinguish it from the Oriental
White-backed Vulture.
Slender-
billed
Vulture
For some time, it was categorized
with its relative, the Indian
Vulture, under the name of "Long-
billed Vulture". The Indian
Vulture is found only to the south
of the Ganges and breeds on cliffs
while the Slender-billed Vulture
is found along the Sub-
Himalayan regions and
into Southeast Asia and nests in
trees. . The population of this
species and the Indian Vulture
declined by 97% overall
Himalaya
n quail
It was last reported in 1876 and
is feared extinct. This species
was known from only 2
locations (and 12 specimens) in
the
western Himalayas inUttarakha
nd, north-west India.