The document discusses the 2.2TB limitation of hard disk drives when using the master boot record (MBR) partitioning scheme. MBR partitioning allows a maximum disk size of 2.2TB due to its use of 32-bit values to describe partition sizes. This limitation can prevent accessing disk space beyond 2.2TB. The document explains that the Unified Extensible Firmware Interface (UEFI) specification defines a new firmware interface and supports the GUID Partition Table (GPT) scheme which uses 64-bit values, allowing for larger partition sizes and handling disks over 9 zettabytes in size. Only operating systems supporting UEFI and GPT are expected to boot from partitions larger than 2.2TB.