This document discusses hematological disorders involving red blood cells, including anemia and polycythemia. It defines different types of anemia such as iron deficiency anemia, pernicious anemia, and sickle cell anemia. For each type it discusses causes, signs and symptoms, diagnosis, treatment, and nursing considerations. It also covers polycythemia vera, defining it as a disorder where the bone marrow produces too many red blood cells, and discusses its pathophysiology, diagnostic tests, and treatment options.
CHRONIC DYSPEPSIA
Seminar Prepared by :-
Ali Abdulazeem
Shilan Adnan Abdulrahman
Alaa Shamil
Guldan Hameed
Internal Medicine
College of Medicine - University of Kirkuk
CHRONIC DYSPEPSIA
Seminar Prepared by :-
Ali Abdulazeem
Shilan Adnan Abdulrahman
Alaa Shamil
Guldan Hameed
Internal Medicine
College of Medicine - University of Kirkuk
Free webinar on " Blood Disorders"
Blood is the main body fluid which delivers necessary nutrients to cells and wastes away from the same cells. Blood disorders are when something in your blood prevents it from doing its job. While some blood disorders are caused by genes, some can develop as a result of other diseases, medications or a lack of nutrients in your diet.
Purpose:
The Purpose of this webinar is to bring knowledge and awareness about blood disorders and their management.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Objectives
• At the end of this presentation the students will be
able to:
• Define blood and discuss its composition.
• Define anemia and identify different types of anemia.
• Discuss polycythemia.
• Enlist causes, signs, symptoms and complications of
different types of anemia & polycythemia.
• Discuss medical diagnosis and treatments for different
types of anemia.
• Make nursing diagnosis and nursing interventions for
anemia.
3. Blood
• Blood is a specialized bodily fluid in humans and
other animals that delivers necessary substances
such as nutrients and oxygen to the cells and
transports metabolic waste products away from
those same cells.
4. Composition of Blood
• Consists of blood cells (45%) suspended & carried in
plasma (55%).
• Total blood volume is about 5-6L.
• Plasma is straw-colored liquid consisting of H20 (90%) &
dissolved solutes
– Includes ions, metabolites, hormones, antibodies and
plasma proteins.
13-7
5. Blood Components
• Plasma:
– The liquid part of blood. All the blood cells are suspended
in this liquid.
– Contains dissolved salts (electrolytes) and proteins
• Albumin helps keeps blood vessels from leaking and carries
hormones and drugs to different parts of the body.
• Antibodies (immunoglobulins) that defend the body against
viruses, fungi, and cancer cells
– Prevents blood vessels from collapsing and clotting by
keeping them filled and circulating
– Plays role in thermoregulation the body
6. Blood Components
• Red Blood Cells
– Erthrocytes: Make up 40% of the blood’s volume
– Produced in the bone marrow
– Contain hemoglobin, a protein that gives blood its red color and
enables it to carry oxygen.
• White Blood Cells
– Leukocytes: Fewer in number than RBCs (1:660)
– Primary responsibility: Defend the body against infection
• Platelets
– Thrombocytes: cell-like particles smaller than RBCs and WBCs.
– Help with clotting process by gathering at bleeding site and
clumping together to form a plug that helps seal the blood vessel.
8. Anemia
Definition:
A reduction in the quantity in the oxygen
carrying pigment hemoglobin in the blood
characterized by excessive tiredness, fatigue, pallor
and poor resistance to infection is called anemia.
10. Iron Deficiency Anemia
• When our body does not have enough iron, it will
make fewer red blood cells or red blood cells that are
too small. This is called iron deficiency anemia.
• Iron deficiency anemia is the most common form
of anemia.
11. Etiology
• Blood loss due to:
o Heavy, long, or frequent menstrual periods
o Cancer in the esophagus, stomach, or colon
o Esophageal varices
o The use of aspirin, ibuprofen, or arthritis medicines
for a long time
o Peptic ulcer disease
• Malabsorption of iron in the intestines due to:
o Celiac disease
o Crohn's disease
• Poor diet such as strict vegetarian.
12. Signs and symptoms
• Feeling weak or tired more often than usual, or with
exercise
• Headaches
• Problems in concentrating or thinking
• Brittle nails
• Pallor
• Shortness of breath.
• Sore tongue.
• Dizziness.
• Coldness in extremities.
14. Treatment
• Dietary Changes and Iron Supplements
• Vitamin C supplements.
• Treatment To Stop Bleeding
• Blood Transfusion for Severe Iron-Deficiency Anemia.
15. Complications
• Severe iron deficiency anemia can cause low oxygen
levels in vital organs such as the heart, kidneys and
can lead to a heart attack and kidney failure.
16. Pernicious Anemia
• Pernicious anemia is a type of vitamin B12 anemia.
• The body needs vitamin B12 to make red blood cells.
this vitamin is got from eating foods such as meat,
poultry, shellfish, eggs, and dairy products.
• A special protein, called intrinsic factor, helps our
intestines to absorb vitamin B12.
• This protein is released by cells in the stomach.
When the stomach does not make enough intrinsic
factor, the intestine cannot properly absorb vitamin
B12.
17. Etiology
Common causes of pernicious anemia include:
• Weakened stomach lining gastritis)
• An autoimmune gastritis in which the body's
immune system attacks intrinsic factor protein or the
cells that make it.
• It may be congenital ,hence the affected babies
cannot absorb vit-b12 properly.
18. Signs and Symptoms
o Fatigue
o Loss of appetite
o Pale skin
o Problems in concentrating
o Shortness of breath, mostly during exercise
o Swollen, red tongue or bleeding gums
20. Hemolytic anemia
• Hemolytic anemia is a condition in which there are
not enough red blood cells in the blood, due to the
premature (Before 120 days) destruction of red
blood cells.
24. Treatment
• Blood Transfusions
• Corticosteroid medicines, such as prednisone, can
stop immune system from, or limit its ability to,
make antibodies (proteins) against red blood cells.
• Plasmapheresis.
• Surgery: Some people who have hemolytic anemia
may need surgery to remove their spleens.
• Blood and Marrow Stem Cell Transplant.
25. Complications
• Severe hemolytic anemia can cause cardiovascular
collapse (failure of the heart and blood pressure,
leading to death).
• Severe anemia can worsen heart disease, lung
disease, or cerebrovascular disease.
26. Folic acid deficiency anemia
• Folic acid deficiency anemia happens when your
body does not get enough folic acid. Folic acid is one
of the B vitamins, and it helps your body make new
cells, including new red blood cells
27. Etiology
• Poor folic acid diet.
• Being pregnant or have some medical problems,
such as sickle cell disease.
• Malabsorption of folic acid in the gut.
• Certain medicines, such as some used
for cancer, rheumatoid arthritis, and seizures.
28. Signs and Symptoms
• Feel weak and tird
• Be forgetful.
• Feel grouchy.
• Lose of appetite and weight lose.
• Problems in concentrating.
30. Treatment
• To treat the anemia, take folic acid pills each day to
bring folic acid level back up.
• After folic acid level is normal, eat foods rich in folic
acid so we don't get anemia again. These foods
include fortified breads and cereals, citrus fruits, and
dark green, leafy vegetables.
31. Aplastic Anemia
• Aplastic anemia is a blood disorder in which the
body's bone marrow doesn't make enough new
blood cells. Bone marrow is a sponge-like tissue
inside the bones. It makes stem cells that develop
into red blood cells, white blood cells, and platelets.
32. Etiology
• Many diseases, conditions, and factors can cause
aplastic anemia, including:
• Toxins, such as pesticides, arsenic, and benzene.
• Radiation and chemotherapy (treatments for cancer).
• Medicines, such as chloramphenicol.
• Autoimmune disorders, such as lupus and
rheumatoid arthritis.
• Hereditary.
33. Signs and Symptoms
• Fatigue (tiredness)
• Shortness of breath
• Swelling or pain in the abdomen or swelling in the
legs caused by blood clots
• Blood in the urine
• Headaches
• Irregular heartbeat
• Heart murmur
34. Diagnosis
• Physical Exam
• Complete Blood Count
• Reticulocyte Count
• Bone Marrow Tests
• Biopsy of bone marrow
35. Treatment
• Blood Transfusions
• Blood and Marrow Stem Cell Transplants
• Medicines to:
o Stimulate bone marrow (erythropoietin)
o Suppress your immune system (antithymocyte
globulin (ATG), cyclosporine, and
methylprednisolone)
o Prevent and treat infections (antibiotic and antiviral
medicines)
36. Sickle Cell Anemia
• Sickle cell anemia is a serious disorder in which the
body makes sickle-shaped red blood cells. “Sickle-
shaped” means that the red blood cells are shaped
like a crescent.
• Sickle cells contain abnormal hemoglobin called
sickle hemoglobin. Sickle hemoglobin causes the
cells to develop a sickle, or crescent, shape.
• This occur because amino acids glutamine is in the
beta chain of hgb is replaced by amino acid valine.
37.
38. Etiology
• Sickle cell anemia is an inherited disease. People who
have the disease inherit two genes for sickle
hemoglobin—one from each parent.
39. Signs and Symptoms
• Shortness of breath
• Dizziness
• Headaches
• Coldness in the hands and feet
• Paler than normal skin or mucous membranes
• Fatigue
• Pain throughout the body.
40. Diagnosis
• Complete blood count (CBC)
• Sickle cell test
• Other tests may include:
o Blood oxygen
o CT scan or MRI
o Peripheral smear
o Serum hemoglobin.
41. Treatment
• The goal of treatment is to manage and control
symptoms, and to limit the number of crises.
• Folic acid supplements should be taken. Folic acid is
needed to make red blood cells.
• Treatment for a sickle cell anemia includes:
• Blood transfusions (may also be given regularly to
prevent stroke)
• Pain medicines
• Plenty of fluids
42. Cont….
• Other treatments for sickle cell anemia may include:
• Hydroxyurea (Hydrea), a medicine that may help
reduce the number of pain episodes (including chest
pain and difficulty breathing) in some people
• Antibiotics to prevent bacterial infections, which are
common in children with sickle cell disease
43. Nursing diagnosis
• Activity intolerance related to weakness, fatigue, and
shortness of breath.
• Imbalanced nutrition less than body requirements
related to anorexia.
• Risk for impaired skin integrity related to
decreased mobility, bed rest and tissue hypoxia.
• High risk of infection related to an inadequate
secondary defenses or a decrease in granulocytes
(inflammatory response depressed)).
• Constipation or diarrhea related to decreased dietary
inputs secondary to changes in the digestive process.
44. Nursing interventions
• Monitor vital signs, color of skin, mucous
membranes.
• Administer medication such as vitamins and mineral
supplements.
• Suggest the patient for balanced diet, avoiding hard
and spicy foods.
• Provide oxygen as needed.
• Assess the capability of the patient to
ingest nutrients or any other barriers such
as being lactose intolerant or has a pancreatic
disease.
45. Cont….
• Encourage intake of folic acid supplements.
• Assist the patient in the activities of daily living.
• Note changes in balance/ gait disturbance, muscle
weakness to indicate neurological changes
associated with vitamin B12 deficiency, affecting
patient safety or risk of injury.
• Elevate the head of the bed to enhances lung
expansion to maximize oxygenation for cellular
uptake.
• Explain necessity for bone marrow aspiration and
biopsy for definitive diagnosis.
47. Polycythemia Vera
Polycythemia Vera or P.V. is a disease where the
bone marrow creates too much red blood cells.
Polycythaemia means “many cells in the
blood”.
It is a rare disease that occurs once in every
200,000 people.
48. Etiology
– Chronic pulmonary or cardiac disease
– High oxygen affinity hemoglobinopathy
– Residence at high altitude
50. Pathophysiology
Polycythaemia Vera is a bone marrow disorder
characterized by erythrocytosis, usually with a
simultaneous leukolytosis and thrombocytosis,
hypervolemia, increased blood viscosity from the
increased RBC mass and platelet dysfunction occur.
51. Symptoms usually are absent in early stage,
circulatory manifestations of polycythaemia Vera
occur b/c of the hypertention caused by
hypervolaemia and hyperviscosity.
They are often the first symptoms and include the
following:
Headache
Vertigo
Dizziness
Tinnitus and visual disturbances.
Signs and symptoms
53. Diagnostic tests
Increased hemoglobin & hematocrit
Normoblasts may be present
Mild to moderate leukocytosis
Mild neutrophilia and/or basophilia
Thrombocytosis
54. Treatment
Phlebotomy (the surgical opening or puncture of a
vein in order to remove blood or infuse fluids or
drugs.
Alkalating agents (busulfan, hydroxyurea,
melphalan).
Radioactive phosphorus or interferon to inhibit bone
marrow activity.
55. Nursing diagnosis
i. Acute pain related to headache.
ii. Deficient knowledge (disease and treatment)
related to lack of exposure to information.
iii. Disturbed sensory perception (visual) related to
hypervolemia.
iv. Impaired gas exchange related to dyspnea.
56. Nursing interventions
Monitor the respiratory status (pulmonary
embolism)
Assess vital signs for signs of hemorrhage
Assess the cardiovascular status to detect
arrhythmias or MI
Reduce the physical activity/ provide bed rest
Monitor the laboratory values to determine
effectiveness of the therapy.
Balanced diet as small frequent meals.
57. Conti…
Measures to maintain body temperature.
Monitor for infection, bleeding , and bruising caused
by decreased platelet level.
Encourage fluids and administer IV fluids to replace
fluid lost by fever and bleeding.
Avoid aspirin and related drugs.
58. References
• Lee MT, Piomelli S, Granger S, et al. Stroke
prevention trial in sickle cell anemia (STOP):
extended follow-up and final results. Blood.
2006;108:847-852.
• Brawley OW, Cornelius LJ, Edwards LR, Gamble VN,
Green BL, Inturrisi C, et al. National Institutes of
Health consensus development conference
statement: hydroxyurea treatment for sickle cell
disease.Ann Intern Med. 2008;148:932-938.
• Geller AK, O'Connor MK. The sickle cell crisis: a
dilemma in pain relief. Mayo Clin Proc. 2008;83:320-
323.