From this slideshow you can learn how to prepare and formulate Cetrimide cream in the laboratory.

1. Pharmaceutics II
LABORATORY EXPERIMENT
PREPARATION & FORMULATION OF CETRIMIDE
CREAM

2. RAFIA SULTANA (1269) - Group Leader
MD.RAFIQUL ISLAM (1194)
SHAIKAT KUMAR BARMAN ( 1164)
HRIDOY KUMER DEY (1155)
SADIA FIROZ (1136)
SUNJIDA MALIHA (1129)
Group :: B

3. What is cream ?
 Pharmaceutical creams are semisolid preparations
containing one or more medicinal agents dissolved or
dispersed in either a W/O emulsion or an O/W
emulsion or in another type of water-washable base.
 Creams have a relatively soft, spreadable consistency;
an example of a W/O cream is cold cream and an
example of an O/W cream is hydrophilic ointment.
 Creams find primary application in topical skin products
and in products used rectally and vaginally.

4. Properties of Cream:
 Absorption: Quickly absorbed by the skin
 Consistencies: Higher
 Greasiness: Less greasy
 Transparency: White
 Conc. of oil: Lower conc. of oil than ointment
 Spreading ability: High
 Stability on skin: Stay short time on surface
 Healing power: Fast.

5. Formula
Ingredient Master formula
(1000 g)
Working
formula (10 g)
Cetrimide 3 g 0.003g
Cetostearyl alcohol 50 g 0.5 g
Liquid paraffin 500 ml 5 ml
Distilled water 1000 ml 10 ml

6. Cetrimide
 Active ingredient of the medicated cream
 An antiseptic agent
 Mixture of different quaternary ammonium
salts including CTAB
Cetrimide bromide

7. Cetrimide

8. Uses of cetrimide
Generally used as a cream for topical use. Also used for :
Prevent infection in – cuts
 Smaller wounds
 Wound cleansing
 Nappy rash
 Seborrhoeic dermatitis
 Minor burns
 Insect’s bites
 Sterilizing surgical instruments etc.

9. Side effects
 Erythematous rash, redness
 Itching, skin irritation
 Paresthesia
 Death of body tissue
 Hypersensitivity reaction.

10. Cetosteryl Alcohol
 A mixture of fatty alcohols, consisting
predominantly of cetyl and alcohol.
 Formula: CH3(CH2)nOH
 Melting point: 50°c.

11. Cetosteryl alcohol
(Picture for reference only)

12. Functions
 Emulsion stabilizer
 Opacifying agent
 Surfactant-foam booster
 Viscosity increasing agent
 Emollient
 Widely used in creams and lotions.

13. Liquid paraffin
 Also known as paraffinium
liquidum, is a very highly
refined mineral oil used for
medicinal purposes.
 Function: to moisturize,
soothe, improve the texture
of skin.

14. At a glance..
Cetrimide Active ingredient
Cetostearyl alcohol Opacifying & viscosity increasing
agent; surfactant
Liquid paraffin Oleaginous vehicle
Distilled water Solvent

15. Apparatus
 Two beakers
 Glass rod
 Thermometer
 container

16. Procedure
 Step 1: measured ingredients in a top loading balance.
 Step 2: heated distilled water in water bath at (60°c -70°c)
 Step 3: took one beaker, prepared oil phase. Cetosteryl
Alcohol was dissolved in liquid paraffin with the help of
hot distilled water.
(Picture for reference only)

17. Procedure cont’d:
 Step 4: took another beaker, prepared water phase.
Cetrimide was dissolved in purified water in the same
temperature.
 Then, dissolved the warm oily phase into aqueous
phase.
 Stirred continuously until emulsion is formed & cool.
(Picture for reference only)

18. Procedure cont’d:
 Used a glass rod to transfer the mixture to a container
or tube.
 Finally, it was ready for labeling and packaging.
 Labeling: All written, printed or graphic material
passing various information of the product stocked to
the container of the product is known as label.

19. Precaution
 All the ingredients are weighed with great care.
 The final volume of the preparation was taken into the
container with care.
 The container was closed tightly.

20. Composition: Each 5 gm contains 1.5 mg of cetrimide
Indication: wounds, cuts, insect’s bite etc.
Side effects: No severe side effects
Caution: For external use only.
Storage: Store in cool and dry place
Batch no: 294419
DAR no:2019-222-531
Mfg. Lic. No: 2944
Mfg. date: December 06, 2018
Exp. date: December 06, 2020
MRP: 25 tk only.
SARAS Pharma Ltd.
Savar, Dhaka.1342

21. Thank you..