2. Definitions:
• Zoonosis: “disease of animals transmissible to
humans under natural conditions”
• Influenza: “an acute viral infection of the respiratory
tract, occurring in isolated cases, epidemics, and
pandemics, caused by Influenzavirus A, B or C … “
(AKA “The Flu”)
• Pandemic: “A widespread epidemic of a disease”
• Epidemic: “Occurring suddenly in numbers clearly
in excess of normal.”
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4. RNA Virus (smaller than
a cell)
Has no cell wall
Invades other cells
Alters the infected cell
and its DNA
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5. ♥♥♥
►► Influenza A is made of 8 parts, called segments
Those 8 segments are used to make 10 larger
components called gene products
These determine certain aspects of the virus
Include products called Hemagglutinin and
Neuraminidase, or HA and NA for short.
Commonly recognized in the name of the
strain of the virus, such as “H1N1”
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6. Control how this virus interacts with the host cell
HA: How well the virus gets along with the host cell1
Friend or foe: “Do I know you?”
Come on in, make yourself at home…
NA: How well the children of the virus can detach from
the inside of the host cell to spread to other cells
Allows the children to “leave the nest”
Children move in with someone else, start their own
families
Why we classify the strain by the H and N variations.
HA and NA?
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7. Hey, look, it’s a party! (The door is open…with
the right HA key…)
Mix with your friends
Decide to stay (Hey, why not, the food is
free, and the party never stops?)
Start talking to the other DNA segments
Spread some urban myths
How about a little Antigenic Drift?
Have children, (slow random genetic
changes)
Kick the kids out when they’re old
enough (replication)
What happens next?
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