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Sharmaine Villamor1
Definitions:
• Zoonosis: “disease of animals transmissible to
humans under natural conditions”
• Influenza: “an acute viral infection of the respiratory
tract, occurring in isolated cases, epidemics, and
pandemics, caused by Influenzavirus A, B or C … “
(AKA “The Flu”)
• Pandemic: “A widespread epidemic of a disease”
• Epidemic: “Occurring suddenly in numbers clearly
in excess of normal.”
Sharmaine Villamor
2
Zoonotic Influenza Pictures
Sharmaine Villamor
3
RNA Virus (smaller than
a cell)
Has no cell wall
Invades other cells
Alters the infected cell
and its DNA
Sharmaine Villamor
4
 ♥♥♥
►► Influenza A is made of 8 parts, called segments
 Those 8 segments are used to make 10 larger
components called gene products
 These determine certain aspects of the virus
 Include products called Hemagglutinin and
Neuraminidase, or HA and NA for short.
 Commonly recognized in the name of the
strain of the virus, such as “H1N1”
Sharmaine Villamor
5
 Control how this virus interacts with the host cell
HA: How well the virus gets along with the host cell1
Friend or foe: “Do I know you?”
Come on in, make yourself at home…
NA: How well the children of the virus can detach from
the inside of the host cell to spread to other cells
Allows the children to “leave the nest”
Children move in with someone else, start their own
families
Why we classify the strain by the H and N variations.
HA and NA?
Sharmaine Villamor
6
 Hey, look, it’s a party! (The door is open…with
the right HA key…)
 Mix with your friends
 Decide to stay (Hey, why not, the food is
free, and the party never stops?)
 Start talking to the other DNA segments
 Spread some urban myths
 How about a little Antigenic Drift?
 Have children, (slow random genetic
changes)
 Kick the kids out when they’re old
enough (replication)
What happens next?
Sharmaine Villamor
7
Sharmaine Villamor
8
Common Zoonotic Disease
Question Areas
Sharmaine Villamor
9

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Zoonotic Influenza

  • 2. Definitions: • Zoonosis: “disease of animals transmissible to humans under natural conditions” • Influenza: “an acute viral infection of the respiratory tract, occurring in isolated cases, epidemics, and pandemics, caused by Influenzavirus A, B or C … “ (AKA “The Flu”) • Pandemic: “A widespread epidemic of a disease” • Epidemic: “Occurring suddenly in numbers clearly in excess of normal.” Sharmaine Villamor 2
  • 4. RNA Virus (smaller than a cell) Has no cell wall Invades other cells Alters the infected cell and its DNA Sharmaine Villamor 4
  • 5.  ♥♥♥ ►► Influenza A is made of 8 parts, called segments  Those 8 segments are used to make 10 larger components called gene products  These determine certain aspects of the virus  Include products called Hemagglutinin and Neuraminidase, or HA and NA for short.  Commonly recognized in the name of the strain of the virus, such as “H1N1” Sharmaine Villamor 5
  • 6.  Control how this virus interacts with the host cell HA: How well the virus gets along with the host cell1 Friend or foe: “Do I know you?” Come on in, make yourself at home… NA: How well the children of the virus can detach from the inside of the host cell to spread to other cells Allows the children to “leave the nest” Children move in with someone else, start their own families Why we classify the strain by the H and N variations. HA and NA? Sharmaine Villamor 6
  • 7.  Hey, look, it’s a party! (The door is open…with the right HA key…)  Mix with your friends  Decide to stay (Hey, why not, the food is free, and the party never stops?)  Start talking to the other DNA segments  Spread some urban myths  How about a little Antigenic Drift?  Have children, (slow random genetic changes)  Kick the kids out when they’re old enough (replication) What happens next? Sharmaine Villamor 7
  • 8. Sharmaine Villamor 8 Common Zoonotic Disease Question Areas