Hepatitis C virus , introduction, type ,pathogenesis, diagnosis treatment, medical microbiology,

1. Hepatitis C virus

2. Hepatitis C virus
Also called : hep C
Hepatitis C virus Infection Caused And spread By contact through contaminated Blood
for examples ; From sharing Needles Or form unsterile tatto equipment..
∆ Hepatitis C virus (HCV) infection is the most common chronic blood borne infection
In United State ;approx 3.2 million person are chronically infected
HCV –virology
Family ; flaviviridae
Genus ; Hepacivirus
∆ A small (50nm) virus
∆ ssRNA virus

3. Structure of hepatitis C virus;
Hepatitis C virus Particles consist of core Of a genetic material
(RNA) , surrounded by An icosahedral protective Sheel of protein
And further covered in a Lipid (Fatty) Envelope Cellular origin …

4. Transmission;

7. • Pathology of Hepatitis C virus
1. Virus cause inflammation of liver
2. Necrosis of hepatocytes (Epithelial cell of liver)
3. Disruption of liver cell cords
4. Accumulation oF Macrophages near degenerating hepatocytes
5. Both hepatitis B & C are cytopathogenic
6. Cellwall damage is immune mediated
7. Carcinoma may appear 15-60 years after the beginning of infection

9. Stages of liver disease;
• Infection & inflammation ; the virus enter the bloodstream and is carried to the liverTothe liver
infecteThe liver cell.And infected liver cell Become damaged and some cell die and causing liver
Swell
• Fibrosis: Continuous inflammation of liver caused by Hepatitis C lead to fibrosis.The
Formation Of sacar Tissue within liver.
• CirrHosis ; Extensivesacring Can blockThe flow Of blood throughTheliver and cause liver
function todeteriorate over time.This is called cirrhosis..
• Hepatocellular carcinoma ; Hepitits c is a leading causes of liver Cancer.The Formation of
malignant tumor in liverAnd ultimately Livet stop workingAnd liver Failure occur.
• Livet transparent: About 50% Of
• Liver transplant Result form the liver damag caused by Hepatitis C virus…

13. Symptoms: