HIV AIDS

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This presentation is made by Dr Ashok Jaisingani for study purpose, if any one like this, than please give comments

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HIV AIDS

  1. 1. Dr. Ashok Jaisingani
  2. 2.  The type I immunodeficiency virus is one of the virus of surgical importance as it can be transmitted by body fluid, particularly blood. It is retrovirus and its prevalence inc. via 1- Sexual Transmission 2- Homo & Heterosexual individuals 3- IV – drugs addictions 4- Through infected blood in treating haemophlias. The risk in surgery mostly through the needle stick injury during the operation.
  3. 3.  After the exposure the virus is bind to CD4 receptors with a subsequent loss of CD4+ cells, T helper cells and other cells involved in cell – mediated immunity, antibody production and delayed hypersensitivity. Macrophages and gut associated lymphoid tissues are also affected. The risk of the opportunistic infections increase are 1- Pneumocystitis Carinii pneumonia 2- Tuberculosis 3- Cytomegalovirus 4- Neoplasm (Kaposi’s sarcoma & lymphoma)
  4. 4.  In the early weeks after the HIV infection there may be a flu – like illness During the phase of seroconversion patients present the greatest risk of HIV transmission It is during these early phases that drug treatment, “highly active anti-retroviral therapy” (HAART) is most effective through the ability of these drugs to inhibit the reverse transcriptase and protease synthesis. Transcriptase and protease synthesis are principle mechanisms through which HIV can progress
  5. 5.  Within10 – years untreated HIV can progress to AIDS in 25 – 35% of the patients, which is considered to be fatal.

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