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Stem Cell Collection and Storage Services 1
Overview Private company launched in 2009, Public in 2009 Adult Stem Cells (ASC) Ageing and Stem Cell Regeneration ASC Sources Why Use Your Own ASC ASC Therapies  Industry Growth and Cell Availability Collection, Preservation and Storage Quality How to Participate
Collect and store autologous (one’s own) stem cells from fat tissue, peripheral blood , cord blood and bone marrow for personal use in medical stem cell therapies Provide genetic profile testing.		 Mission
Management 1 Tony Digiamberardino, MD Medical Director U.S. and Dominican Republic Mario IzurietaUlloa, MD  Director of Medical Advisory Board Abraham Jacob, MD Medical Advisory Board David Lee, MD  Director of Stem Cell Research and Laboratory Operations
Management 2 Steven Swank CFO and Vice President of Finance Armando Casciati CEO and President Erick Mathe Vice President of Investment and Public Relations Outside Consultants – J.M.Yang Prof. of Sungkyunkwan Univ. Dermatology Chief of SMC H.G.Chol Prof. of Chosun Univ. Drug Shape Developer Expert B.G.Park Prof. of SNU Virus Expert S.H.Kim Prof. of Kyunghee Univ. Cancer & Chinese Medicine Expert
Stem cells form at conception and differentiate to build our tissues and organs – before birth they are embryonic stem cells After we are born, stem cells continue to be produced in bone marrow - these are Adult Stem Cells (ASC) ASC are unique - the body’s natural master repair cells They are unspecialized and can self renew indefinitely They can differentiate to become almost any cell in the body ASC circulate in our system throughout our life to repair and regenerate tissues and organs naturally About Adult Stem Cells or ASC
Adult Stem Cell Dynamics
Cells are damaged by mutation, toxins, pathogens and oxidation  - the immune system must respond  To fight disease at a cellular level with T cells, B cells etc. Engulf and eliminate damaged cells – macrophages, dendritic cells, etc. Over time the cellular immune function diminishes Stem cells themselves mutate and become damaged We become more susceptible to disease Organ and tissue regeneration becomes more difficult Fewer viable stem cells are produced  - jeopardizing repair and regeneration capability The Aging Process
“We Age … Because Our Stem Cells Grow Old”
An infusion of  healthy ASC cells migrate to the marrow and boosts the blood and immune system  Replicate, increasing by the millions Differentiate to produce all of our blood cells – red, white, etc. ASC circulate to all of our tissues and organs seeking damage Proximity effects drive differentiation to produce new cells ASC continue to differentiate to regenerate tissue and organs The younger the ASC the better the potency and results	 How ASC Therapy Works
ASC used to treat ~80 diseases as 1st or 2nd treatment modality Blood cancer, anemia, genetic diseases Over 2000 ASC clinical trials in progress in the US alone Lupus Breast cancer Diabetes, Type 1 Multiple Sclerosis Congestive Heart Failure  Anemia’s: Sickle Cell, Fanconi, Aplastic Regeneration of Heart Tissue post heart attack Pad Alzheimer Advances in ASC Therapy
Your Stem Cells vs. Cell Bank
PHASE I (983) PHASE II (1307) 1923 Cancer 449 Cardiovascular 33 Diabetes 4 Stroke 22 Wound Healing PHASE III (721) 598 Cancer 65 Cardiovascular 22 Breast Cancer 8 Diabetes 28 Wound Healing ASC Clinical and Research Trials
Originally bone marrow was the source of ASC  Family and donors provide cells when there is a match Painful and expensive Cord blood replacing marrow as a preferred source of  ASC Used by donor and family when matching cells are available Easy and affordable to obtain and store Today you can store your own ASC harvested from blood Always have perfectly matched cells available Eliminates the risk of rejection or Graft-vs-Host Disease Easy and affordable to obtain and store History of ASC Sources
Cord blood banking growth 10% of all US births today vs. 1% in 2000 Projected growth of ASC industry $800M in 2007, $1.7B in 2010 Demand for cells will quickly outstrip public bank capabilities 100,000 cord blood units available for 300M Americans Matching cells for minorities <10% Demand for matching cells and assured availability driving personal storage alternatives A Rapidly Growing Industry
Enrollment via web, fax or phone Collection kit shipped to your home FROM BLOOD Phlebotomist collects blood at patient home or office, or Take kit to your doctor for blood collection FROM FAT A mini lipo collects 10 grams of fat from your belly Blood or Fat are shipped by medical courier overnight for processing  Samples sent to OUR lab for testing  When tests are ok the cultivation process initiates The Collection Process
Blood is processed and stored in a closed, sterile system  Integrated processing and storage compartments Computer automated system supplied by GE and Thermogenesis, leaders in the stem cell processing industry Proven methods for stabilization and controlled cryopreservation Best recovery rates in the industry Stem cells are preserved in their natural serum environment  Keeps cells in their undifferentiated state Optimizes long term storage and viability upon thawing The Preservation and Storage Process
AXP Processing System ,[object Object]
Module fits into standard centrifuge
Microprocessor senses rotational speed and controls flow of blood cells into different compartments of plastic processing kit
Recovers 94% of total mononucleated cells and stem cells,[object Object]
Stem Cells Ready for Cryopreservation Samples bar coded, sealed inside Teflon and sealed in bar coded steel cassettes for storage
BioArchiveTM ,[object Object]
 Controlled cooling module uses liquid nitrogen vapor to slowly cool cells to-56 C
 Samples then moved into liquid nitrogen for long term storage

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Regenobody

  • 1. Stem Cell Collection and Storage Services 1
  • 2. Overview Private company launched in 2009, Public in 2009 Adult Stem Cells (ASC) Ageing and Stem Cell Regeneration ASC Sources Why Use Your Own ASC ASC Therapies Industry Growth and Cell Availability Collection, Preservation and Storage Quality How to Participate
  • 3. Collect and store autologous (one’s own) stem cells from fat tissue, peripheral blood , cord blood and bone marrow for personal use in medical stem cell therapies Provide genetic profile testing. Mission
  • 4. Management 1 Tony Digiamberardino, MD Medical Director U.S. and Dominican Republic Mario IzurietaUlloa, MD Director of Medical Advisory Board Abraham Jacob, MD Medical Advisory Board David Lee, MD Director of Stem Cell Research and Laboratory Operations
  • 5. Management 2 Steven Swank CFO and Vice President of Finance Armando Casciati CEO and President Erick Mathe Vice President of Investment and Public Relations Outside Consultants – J.M.Yang Prof. of Sungkyunkwan Univ. Dermatology Chief of SMC H.G.Chol Prof. of Chosun Univ. Drug Shape Developer Expert B.G.Park Prof. of SNU Virus Expert S.H.Kim Prof. of Kyunghee Univ. Cancer & Chinese Medicine Expert
  • 6. Stem cells form at conception and differentiate to build our tissues and organs – before birth they are embryonic stem cells After we are born, stem cells continue to be produced in bone marrow - these are Adult Stem Cells (ASC) ASC are unique - the body’s natural master repair cells They are unspecialized and can self renew indefinitely They can differentiate to become almost any cell in the body ASC circulate in our system throughout our life to repair and regenerate tissues and organs naturally About Adult Stem Cells or ASC
  • 7. Adult Stem Cell Dynamics
  • 8. Cells are damaged by mutation, toxins, pathogens and oxidation - the immune system must respond To fight disease at a cellular level with T cells, B cells etc. Engulf and eliminate damaged cells – macrophages, dendritic cells, etc. Over time the cellular immune function diminishes Stem cells themselves mutate and become damaged We become more susceptible to disease Organ and tissue regeneration becomes more difficult Fewer viable stem cells are produced - jeopardizing repair and regeneration capability The Aging Process
  • 9. “We Age … Because Our Stem Cells Grow Old”
  • 10. An infusion of healthy ASC cells migrate to the marrow and boosts the blood and immune system Replicate, increasing by the millions Differentiate to produce all of our blood cells – red, white, etc. ASC circulate to all of our tissues and organs seeking damage Proximity effects drive differentiation to produce new cells ASC continue to differentiate to regenerate tissue and organs The younger the ASC the better the potency and results How ASC Therapy Works
  • 11. ASC used to treat ~80 diseases as 1st or 2nd treatment modality Blood cancer, anemia, genetic diseases Over 2000 ASC clinical trials in progress in the US alone Lupus Breast cancer Diabetes, Type 1 Multiple Sclerosis Congestive Heart Failure Anemia’s: Sickle Cell, Fanconi, Aplastic Regeneration of Heart Tissue post heart attack Pad Alzheimer Advances in ASC Therapy
  • 12. Your Stem Cells vs. Cell Bank
  • 13. PHASE I (983) PHASE II (1307) 1923 Cancer 449 Cardiovascular 33 Diabetes 4 Stroke 22 Wound Healing PHASE III (721) 598 Cancer 65 Cardiovascular 22 Breast Cancer 8 Diabetes 28 Wound Healing ASC Clinical and Research Trials
  • 14. Originally bone marrow was the source of ASC Family and donors provide cells when there is a match Painful and expensive Cord blood replacing marrow as a preferred source of ASC Used by donor and family when matching cells are available Easy and affordable to obtain and store Today you can store your own ASC harvested from blood Always have perfectly matched cells available Eliminates the risk of rejection or Graft-vs-Host Disease Easy and affordable to obtain and store History of ASC Sources
  • 15. Cord blood banking growth 10% of all US births today vs. 1% in 2000 Projected growth of ASC industry $800M in 2007, $1.7B in 2010 Demand for cells will quickly outstrip public bank capabilities 100,000 cord blood units available for 300M Americans Matching cells for minorities <10% Demand for matching cells and assured availability driving personal storage alternatives A Rapidly Growing Industry
  • 16. Enrollment via web, fax or phone Collection kit shipped to your home FROM BLOOD Phlebotomist collects blood at patient home or office, or Take kit to your doctor for blood collection FROM FAT A mini lipo collects 10 grams of fat from your belly Blood or Fat are shipped by medical courier overnight for processing Samples sent to OUR lab for testing When tests are ok the cultivation process initiates The Collection Process
  • 17. Blood is processed and stored in a closed, sterile system Integrated processing and storage compartments Computer automated system supplied by GE and Thermogenesis, leaders in the stem cell processing industry Proven methods for stabilization and controlled cryopreservation Best recovery rates in the industry Stem cells are preserved in their natural serum environment Keeps cells in their undifferentiated state Optimizes long term storage and viability upon thawing The Preservation and Storage Process
  • 18.
  • 19. Module fits into standard centrifuge
  • 20. Microprocessor senses rotational speed and controls flow of blood cells into different compartments of plastic processing kit
  • 21.
  • 22. Stem Cells Ready for Cryopreservation Samples bar coded, sealed inside Teflon and sealed in bar coded steel cassettes for storage
  • 23.
  • 24. Controlled cooling module uses liquid nitrogen vapor to slowly cool cells to-56 C
  • 25. Samples then moved into liquid nitrogen for long term storage
  • 26. Stored samples never experience transient warming events responsible for cell death
  • 27.
  • 28. Prices vary depending on the number of cells to be cultivated. Average cost including storage is $10,000 Travel costs, specialists, therapies and medical procedures associated with your specific needs are your personal responsibility The average stem cell procedure ranges from $50,000 to $60,000 US dollars Pricing
  • 29. Service Pricing Single Adult Collection $ 4,995.00 Newborn $ 2,495.00 Multiple Birth Newborns $ 1,995.00
  • 30. Storage Pricing Annual Fee $ 600.00 5 year pre-pay $ 2,400.00 $480/yr Discount of 20% 10 year pre-pay $ 4,200.00 $420/yr Discount of 30% 20 year pre-pay $ 7,800.00 $390/yr Discount of 35%

Editor's Notes

  1. Thermogenesis developed the automated AXP and BioArhcive with the New York Blood Center and the FDA over a period of ten years. Thermogenesis published validation studies conducted with the New York Blood Center on their web site in 2006.“Assessment of Automated Cord Blood Processing: CFU and CD34+ Cell Recovery”, L. Dobrilla et. al., National Cord Blood Program, New York Blood Center, NY, NY and Thermogenesis Corp. Rancho Cordova. I takes 3.5 hours to process one client’s sample