Cord blood (umbilical cord blood) is the blood that remains in the placenta and in the attached umbilical cord after childbirth. Cord blood is collected because it contains stem cells, which can be used to ... Blood · Childbirth ·

1. PRESENTEDBY:- DR. Rinki Kumari
Departmentof Biotechnology

2. • Blood remaining in the umbilical
cord and placenta after birth is
called as Umbilical Cord Blood stem
cell is also known as Cord Blood.
• The blood is rich in stem cells
derived from the Umbilical Cord
and placenta after birth.
• After the birth Umbilical Cord
Blood taken from umbilical vein
after cord is cut and clamped.
• UCB blood can be stored for
more than 20 years.

3. •During prenatal development, the
umbilical cord is physiologically and
genetically part of the fetus and (in
humans) normally contains two arteries
(the umbilical arteries) and one vein
(the umbilical vein), buried within
Wharton's jelly.
•The umbilical vein supplies the fetus
with oxygenated, nutrient- rich blood
from the placenta.
•Conversely, the fetal heart pumps
deoxygenated, nutrient-depleted blood
through the umbilical arteries back to the
placenta
Picture showing cross section of
umbilical cord. Top right and top left:
umbilical artery, bottom: umbilical
vein, middle: remnant
of allantois.

4. • 1974 First report on stem/progenitor
cells in human cord blood.
• 1988 First successful cord blood transplant
to regenerate blood and immune cells in
Paris, France on a six- year-old boy
suffering from Fanconi's Anemia, a blood
disorder donor was his identical sister.
• At the time of the first transplant, little
Edward .A.
BoyseH. E.
Broxmeyer

6. Cord blood
collection
Healthy
baby

7. • After the collection, the cord blood unit is
shipped to the lab and processed, and
then cryopreserved.
• However the unit is processed, a
cryopreservant is added to the cord
blood to allow the cells to survive the
cryogenic process.
• cryoprotectants such as glycerol or
dimethyl sulphoxide.
• After cryogenicprotectants added blood
unit should be placed in freezer or extra
cold vessel
• Eg :- Nitrogen liquid (-196 degree
celsius)

8. • CB blood contain stem
cell which is also known
as haematopoietic cell or
progenitor cell.
• This stem cell further turn
into different cells, like
RBC, WBC, Monocytes,
Lymphocytes, Platelet, B-
cell, T-cell, NK- cell etc.
• This stem cell help to
cure 80+ diseases.

9. Stem cells can be stored and used to treat
over 80+ diseases including leukemia,
lymphoma and more.

10. • RELIANCE LIFE SCIENCE First
public CB bank(2002).
• LIFE CELL INDIAS First CB bank (2004).
• Cryobank International associated with RJ
crop and founded Cryobank India (2006)
• Stemcyte Inc. USA associated with Apollo
hospital Ahmadabad found stemcyte
India(2007).
• Jeevan stem cell bank public as well as private.
• CordCare bank founded by Pathcare pvt.
Ltd is public CB bank.

11. • Not much difference
in price to preserve
CB by different CB
bank.
• Minimum 70,000 and
maximum 1,50,000
Rupees.
• Its very cheap
and amazing gift
from parents to
their children or
baby.

12. Cord Blood Banking (Private) Cord Blood
Banking (Public)
• Costs $1000-2000
initially
+ ~$100/year
• Ownership of the
blood retained by
the family
• Cost: free
• Blood donated and not
reserved for child or
family
• May be used for research
in some instances (read
informed consent)

13. • Tata Memorial
Hospital, Mumbai
• AdyarCancer Centre,
Chennai
• Apollo Specialty
Hospital, Chennai
• Apollo Hospital, Hyderabad
• Christian Medical
College, Vellore
• R&R Army Hospital, New
Delhi
• AIIMS, New Delhi
• Inlaks Hospital, Pune
• Armed Forces Medical
College, Pune
• Sanjay Gandhi PGIMS,
Lucknow.

14. 1.Diabetes
(National Centre for Cell Sciences, Pune
University – Dr. Ramesh Bhonde)
2.Heart (Dr. Venugopal Rao –
AIIMS) 3.Liver Disease
4.Parkinson's Disease (Manipal Dr. Satish
Totey) 5.Spinal Cord Injury (AFMC, Pune)
6.Stroke
7.Alzheimer's
Disease

15. Definition
• The human leukocyte antigen test, also known as HLA,
is a test that detects antigens (genetic markers) on
white blood cells. There are four types of human
leukocyte antigens: HLA- A, HLA-B, HLA-C, and HLA-
D.
Purpose
• The HLA test is used to provide evidence of tissue
compatibility typing of tissue recipients and donors. It is
also an aid in genetic counseling and in paternity
testing.
Precautions
• This test may have to be postponed if the patient has
recently
undergone a transfusion.

16. •Preparation
The HLA test requires a blood sample. There is no
need for the patient to be fasting (having nothing to
eat or drink) before the test.
•Risks
Risks for this test are minimal, but may include
slight bleeding from the blood-drawing site, fainting
or feeling lightheaded after venipuncture, or
hematoma (blood accumulating under the puncture
site).

17. • Cord blood is a rich, natural, controversy-free source
of life- saving stem cells.
• The collection of cord blood does not harm the mother
or
child, and does not interfere with the birthing process.
• Umbilical cord blood has the potential to cure
over 80 diseases.
• Recent research has shown tremendous potential for
cord blood stem cells to be used in regenerative
medicine, which may cure even more diseases.
• cord blood is readily available when needed, if
collected and banked.
• Cord blood stem cells are the “youngest” and most adaptable
form of cells, and the body more readily accepts the
cells into its system.

18. •Cord blood has a broader match potential than bone
marrow, which means that the patient and donor do not
have to be a “perfect match.”
•Cord blood stem cells are more resistant to infection,
have fewer side effects after the transplant and
require fewer transplant drugs than bone marrow
stem cells.
•There are nearly 10 times as many blood producing
cells in cord blood. Studies suggest that cord blood may
also have a better ability to generate blood cells than
bone marrow. This provides more opportunity for future
medical advancements.

19. • The main disadvantage of cord blood is that the
volume collected is fixed and relatively small.
• Therefore, the number of stem cells available for
transplantation is low compared to the number of cells
that can be collected in customizable bone marrow or
peripheral blood stem cell harvests.
• It’s avery costly in privatebank.
• Risk of high contamination .
• High risk to be missmatch genetic typing.

20. • Source of stem cells
from biological waste.
• Collection of cord stem
cells is painless.
• Collection of cord stem cells is
risk
free to mother and baby.
• Cord blood stem cells are much
more tolerant to HLA tissue
mismatching than bone marrow
therefore leading to lower rate.• Cord blood stem cells have
agreater ability to differentiate
into other cell types.
• Save Cord blood save your
future
• Cord blood stem cells are being
used in the treatment of 40
medical conditions with over 72
potential disease targets

21. • Umbilical cord blood wikkipedia
• Placenta wikkipedia
• Umbilical Cord wikkipedia
• Americord Bank (US)
• Jayanti Tokas, Puneet Tokas, Rubina Begum,
Shailini Jain
and Hariom Yadav
Department of Biotechnology, JMIT, Radaur,
Haryana, India KITM, Kurukshetra,
Haryana, India

22. • Christina Bemrich(Tinsley Harrison Research
Society).
• Elisabeth Semple, PhD Scientific Director
Cells for Life Cord Blood Institute Toronto.
• Cryo-Save India .com
•Relicord.com
•Jeevan stem cell bank.
•Life cell stem cell
•Stemcyte .com
•parentsguidecordblood.org
•bmt.umn.edu
health.india.com
•medical-dictionary.thefreedictionary.com
•cordblood.findthebest.com
•www.alphacord.com
•www.newindianexpress.com
•www.cordcareindia.com
•www.pharmabiz.com
•www.slideshare.net