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  1. 1.
  2. 2. AUTOMATION AND ROBOTICS IN DRUG DISCOVERY PROCESS Presented by, B.Abhinay, M.Pharm, Pharmacology, C.M.R.C.P . Under the guidance of, Ms. Meenu Singh, M.Pharm (Ph.D), Asst. Proffesor, C.M.R.C.P.
  3. 3. <ul><li>Overview of Drug Discovery </li></ul><ul><li>Selecting Robots for Use in Drug </li></ul><ul><li>discovery and Testing </li></ul><ul><li>Instrumentation </li></ul>INDEX
  4. 4. Overview of drug discovery process
  5. 5. Overview of DDP
  6. 6. Serendipity
  7. 7. Pharmaceutical Industry Challenges Opportunities <ul><li>Increasing cost of R&D </li></ul><ul><li>Pressure on pricing </li></ul><ul><li>Low output of new products </li></ul><ul><li>Fierce competition </li></ul><ul><li>Increased regulatory hurdles </li></ul>New windows of innovation – Genomics – Proteomics – Biotechnology – Combinatorial Chemistry • Better understanding of the mechanism of disease Robotics and Automation play a role in each area
  8. 8. New Tools for Drug Discovery • Genomics • Proteomics • Bioinformatics • High-throughput screening • Combinatorial chemistry • Micro array technology
  9. 9. Drug Discovery & Development Target discovery Screening Lead-optimis-ation ADMET Develop-ment Registr-ation Where do Automation and Robotics play a key role?
  10. 10. Selecting Robots for Use in Drug discovery and Testing
  11. 11. ROBOT?
  12. 12. DEFINITION: &quot;A reprogrammable, multifunctional manipulator designed to move material, parts, tools, or specialized devices through various programmed motions for the performance of a variety of tasks&quot; Robot Institute of America, 1979
  13. 13. Benefits of using Robots in Drug Discovery and Testing <ul><li>Faster, more consistent and more cost-effective </li></ul><ul><li>High degree of repeatability </li></ul><ul><li>Every parameter in </li></ul><ul><li>the process can be automatically monitored, recorded and </li></ul><ul><li>verified </li></ul><ul><li>Thorough documentation is possible </li></ul>
  14. 14. Types of Robots There are three types of industrial robots most commonly used in drug discovery and testing: (1) Cartesian (2) SCARA(selective compliance articulated robot arm) (3) Articulated.
  15. 15. Cartesian Robots
  16. 16. <ul><li>Chief advantage of Cartesian robots </li></ul><ul><li>Low in cost </li></ul><ul><li>Often incorporated into automation subsystems or </li></ul><ul><li>machines dedicated to a single purpose, such as assay testing </li></ul><ul><li>Disadvantage </li></ul><ul><li>although their restricted range of motion limits their usage. </li></ul>
  17. 17. SCARA Robots <ul><li>Selective Compliance Articulated Robot Arm </li></ul><ul><li>The unique design of SCARAs gives them a high degree of rigidity </li></ul><ul><li>moves very fast and with </li></ul><ul><li>precise repeatability </li></ul><ul><li>SCARAs excel at high-speed </li></ul><ul><li>pick-and-place and other material-handling tasks. </li></ul>
  18. 18. Articulated Robots
  19. 19. <ul><li>vertically rotating “forearm” </li></ul><ul><li>and two vertically rotating “wrist” joints, let them </li></ul><ul><li>perform many of the same types of movements as a human </li></ul><ul><li>forearm and wrist </li></ul><ul><li>pick up an object no matter how it is oriented off </li></ul><ul><li>the horizontal plane </li></ul>
  20. 20. Instrumentation
  21. 21. Screening Compound Collections Natural Product Libraries (>200,000 extracts) Synthetic Libraries (>1,000,000 compounds) Rapid hit Vary screen
  22. 22. Preparation of Chemical Substances Synthesis <ul><li>Microwave Synthesizers </li></ul><ul><li>Automated Synthesizers </li></ul><ul><li>Pipettes and other precision </li></ul><ul><li>Lquid dispensing and transferring devices </li></ul>Rapid, time efficient Synthesis of multiple compounds simultaneously (1) (2) (4)
  23. 23. Preparation of Chemical Substances <ul><li>Largest use of Robotics and Automated Technology for bench chemist </li></ul><ul><li>Robotics provide more advanced equipment for parallel synthetic applications(synthesize up to 8 large samples ,product scale between 100 mg and 20 g) </li></ul><ul><li>Sample weighing to 0.0001 g accuracy </li></ul>(1) Sample synthesis rob ot
  24. 24. Preparation of Chemical Substances <ul><ul><li>Multi-channel automated equipment allows for rapid purification (mg to gm scale) </li></ul></ul><ul><ul><li>Purification of 10’s to 1000’s of compounds could not be possible </li></ul></ul><ul><li>Saves time </li></ul><ul><li>Reduces cost </li></ul><ul><li>Reduces waste stream </li></ul><ul><li>Higher purity compounds </li></ul><ul><li>Allows chemist to multi-task </li></ul>Purification parallel purification robot
  25. 25. Preparation of Chemical Substances <ul><li>Addresses the need for Quality Control and Substance Identification </li></ul><ul><li>Equipment allows for: </li></ul><ul><ul><ul><ul><ul><li>Sample submission </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Data acquisition </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Data processing </li></ul></ul></ul></ul></ul><ul><li>Allows chemist to obtain accurate results and uncompromising quality </li></ul>Purification
  26. 26. <ul><li>Preparation of multiple daughter plates </li></ul><ul><li>Register bar-coded vials </li></ul><ul><li>Generate registration spreadsheets </li></ul>Preparation of Chemical Substances <ul><li>Ability to Rapidly perform tedious </li></ul><ul><li>Repetitive task </li></ul><ul><li>Consistently accurate </li></ul>
  27. 27. <ul><li>Automated synthesis, along with high throughput purification, have significantly impacted the drug discovery process by improving purity, yield and reproducibility. </li></ul><ul><li>From synthesis to purification, robotics and automated techniques play a key role in the synthesis of new chemical entities . </li></ul>More compounds, less time = Cost effective Summary
  28. 28.
  29. 29. References 1)DENSORobotics-Selecting Robots for Use in Drug Discovery and Testing 2) Medicinal Chemistry & Drug Discovery, Dr. Peter Wipf Department of Chemistry University of Pittsburgh http://ccc.chem.pitt.edu/wipf/index.html 3) AMRI-Drug Discovery and Development: Applications of Robotics and High-Throughput Instrumentation Brian T. Gregg, Ph.D. Research Fellow Medicinal Chemistry, June 25, 2007