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1
AUTOMATION AND
ROBOTICS IN DRUG
DISCOVERY PROCESS
Presented by,
B.Abhinay,
M.Pharm,
Pharmacology,
C.M.R.C.P.
Under the guidance of,
Ms. Meenu Singh,
M.Pharm (Ph.D),
Asst. Proffesor,
C.M.R.C.P.
2
 Overview of Drug Discovery
 Selecting Robots for Use in Drug
discovery and Testing
 Instrumentation
INDEX
3
Overview of drug discovery
process
4
Overview of DDP
5
Serendipity
6
Pharmaceutical Industry
Challenges Opportunities
•Increasing cost of R&D
•Pressure on pricing
• Low output of new
products
•Fierce competition
•Increased regulatory
hurdles
New windows of innovation
– Genomics
– Proteomics
– Biotechnology
– Combinatorial Chemistry
• Better understanding of the
mechanism of disease
Robotics and
Automation play a role in
each area 7
New Tools for Drug Discovery
• Genomics
• Proteomics
• Bioinformatics
• High-throughput screening
• Combinatorial chemistry
• Micro array technology
8
Drug Discovery & Development
Target
discovery Screening
Lead-
optimis-
ation
ADMET
Develop-
ment
Registr-
ation
Where do Automation and Robotics play a key role?
9
Selecting Robots for Use in
Drug
discovery and Testing
10
ROBOT?
11
DEFINITION:
"A reprogrammable, multifunctional manipulator
designed to move material, parts, tools, or specialized
devices through various programmed motions for the
performance of a variety of tasks"
Robot Institute of America, 1979
12
Benefits of using Robots in Drug
Discovery and Testing
•Faster, more consistent and more cost-effective
•High degree of repeatability
• Every parameter in
the process can be automatically monitored, recorded and
verified
•Thorough documentation is possible
13
Types of Robots
There are three types of industrial robots most commonly used
in drug discovery and testing:
(1) Cartesian
(2) SCARA(selective compliance articulated robot arm)
(3) Articulated.
14
Cartesian Robots
15
Chief advantage of Cartesian robots
• Low in cost
•Often incorporated into automation subsystems or
machines dedicated to a single purpose, such as assay
testing
Disadvantage
•although their restricted range of motion limits their
usage.
16
SCARA Robots
•Selective Compliance
Articulated Robot Arm
•The unique design of SCARAs
gives them a high degree of
rigidity
•moves very fast and with
precise repeatability
•SCARAs excel at high-speed
pick-and-place and other
material-handling tasks.
17
Articulated Robots
18
•vertically rotating “forearm”
and two vertically rotating “wrist” joints, let them
perform many of the same types of movements as a human
•forearm and wrist
pick up an object no matter how it is oriented off
the horizontal plane
19
Instrumentation
20
Screening Compound Collections
Natural Product Libraries (>200,000 extracts)
Synthetic Libraries (>1,000,000 compounds)
Rapid hit
Vary screen
21
Preparation of Chemical
Substances
Synthesis
1) Microwave Synthesizers
2) Automated Synthesizers
3) Pipettes and other precision
4) Lquid dispensing and transferring
devices
Rapid, time efficient Synthesis of
multiple compounds
simultaneously
(1)
(2)
(4) 22
Preparation of Chemical Substances
1) Largest use of Robotics and Automated Technology for bench
chemist
2) Robotics provide more advanced equipment for parallel
synthetic applications(synthesize up to 8 large samples ,product
scale between 100 mg and 20 g)
3) Sample weighing to 0.0001 g accuracy
(1)
Sample synthesis robot
23
Preparation of Chemical Substances
• Multi-channel automated equipment allows for rapid
purification (mg to gm scale)
• Purification of 10’s to 1000’s of compounds could not be
possible
Saves time
Reduces cost
Reduces waste stream
Higher purity compounds
Allows chemist to multi-task
Purification
parallel purification robot
24
Preparation of Chemical Substances
•Addresses the need for Quality Control and Substance
Identification
•Equipment allows for:
Sample submission
Data acquisition
Data processing
Allows chemist to obtain accurate results and
uncompromising quality
Purification
25
•Preparation of multiple daughter plates
•Register bar-coded vials
•Generate registration spreadsheets
Preparation of Chemical Substances
Ability to Rapidly perform tedious
Repetitive task
Consistently accurate
26
Automated synthesis, along with high throughput purification, have
significantly impacted the drug discovery process by improving purity,
yield and reproducibility.
From synthesis to purification, robotics and automated techniques play
a key role in the synthesis of new chemical entities.
More compounds, less time = Cost effective
Summary
27
MITSUBISHI ELECTRI SCARA ROBOT RH-6SH RH-6SDH.flv
Epson has 3 types of robots, Scara, Cartesian, & 6 axis.flv
28
References
1)DENSORobotics-Selecting Robots for Use in Drug
Discovery and Testing
2) Medicinal Chemistry & Drug Discovery, Dr. Peter Wipf
Department of Chemistry University of Pittsburgh
http://ccc.chem.pitt.edu/wipf/index.html
3) AMRI-Drug Discovery and Development: Applications
of Robotics and High-Throughput Instrumentation
Brian T. Gregg, Ph.D. Research Fellow
Medicinal Chemistry, June 25, 2007
29
30
31

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Abhinay

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  • 2. AUTOMATION AND ROBOTICS IN DRUG DISCOVERY PROCESS Presented by, B.Abhinay, M.Pharm, Pharmacology, C.M.R.C.P. Under the guidance of, Ms. Meenu Singh, M.Pharm (Ph.D), Asst. Proffesor, C.M.R.C.P. 2
  • 3.  Overview of Drug Discovery  Selecting Robots for Use in Drug discovery and Testing  Instrumentation INDEX 3
  • 4. Overview of drug discovery process 4
  • 7. Pharmaceutical Industry Challenges Opportunities •Increasing cost of R&D •Pressure on pricing • Low output of new products •Fierce competition •Increased regulatory hurdles New windows of innovation – Genomics – Proteomics – Biotechnology – Combinatorial Chemistry • Better understanding of the mechanism of disease Robotics and Automation play a role in each area 7
  • 8. New Tools for Drug Discovery • Genomics • Proteomics • Bioinformatics • High-throughput screening • Combinatorial chemistry • Micro array technology 8
  • 9. Drug Discovery & Development Target discovery Screening Lead- optimis- ation ADMET Develop- ment Registr- ation Where do Automation and Robotics play a key role? 9
  • 10. Selecting Robots for Use in Drug discovery and Testing 10
  • 12. DEFINITION: "A reprogrammable, multifunctional manipulator designed to move material, parts, tools, or specialized devices through various programmed motions for the performance of a variety of tasks" Robot Institute of America, 1979 12
  • 13. Benefits of using Robots in Drug Discovery and Testing •Faster, more consistent and more cost-effective •High degree of repeatability • Every parameter in the process can be automatically monitored, recorded and verified •Thorough documentation is possible 13
  • 14. Types of Robots There are three types of industrial robots most commonly used in drug discovery and testing: (1) Cartesian (2) SCARA(selective compliance articulated robot arm) (3) Articulated. 14
  • 16. Chief advantage of Cartesian robots • Low in cost •Often incorporated into automation subsystems or machines dedicated to a single purpose, such as assay testing Disadvantage •although their restricted range of motion limits their usage. 16
  • 17. SCARA Robots •Selective Compliance Articulated Robot Arm •The unique design of SCARAs gives them a high degree of rigidity •moves very fast and with precise repeatability •SCARAs excel at high-speed pick-and-place and other material-handling tasks. 17
  • 19. •vertically rotating “forearm” and two vertically rotating “wrist” joints, let them perform many of the same types of movements as a human •forearm and wrist pick up an object no matter how it is oriented off the horizontal plane 19
  • 21. Screening Compound Collections Natural Product Libraries (>200,000 extracts) Synthetic Libraries (>1,000,000 compounds) Rapid hit Vary screen 21
  • 22. Preparation of Chemical Substances Synthesis 1) Microwave Synthesizers 2) Automated Synthesizers 3) Pipettes and other precision 4) Lquid dispensing and transferring devices Rapid, time efficient Synthesis of multiple compounds simultaneously (1) (2) (4) 22
  • 23. Preparation of Chemical Substances 1) Largest use of Robotics and Automated Technology for bench chemist 2) Robotics provide more advanced equipment for parallel synthetic applications(synthesize up to 8 large samples ,product scale between 100 mg and 20 g) 3) Sample weighing to 0.0001 g accuracy (1) Sample synthesis robot 23
  • 24. Preparation of Chemical Substances • Multi-channel automated equipment allows for rapid purification (mg to gm scale) • Purification of 10’s to 1000’s of compounds could not be possible Saves time Reduces cost Reduces waste stream Higher purity compounds Allows chemist to multi-task Purification parallel purification robot 24
  • 25. Preparation of Chemical Substances •Addresses the need for Quality Control and Substance Identification •Equipment allows for: Sample submission Data acquisition Data processing Allows chemist to obtain accurate results and uncompromising quality Purification 25
  • 26. •Preparation of multiple daughter plates •Register bar-coded vials •Generate registration spreadsheets Preparation of Chemical Substances Ability to Rapidly perform tedious Repetitive task Consistently accurate 26
  • 27. Automated synthesis, along with high throughput purification, have significantly impacted the drug discovery process by improving purity, yield and reproducibility. From synthesis to purification, robotics and automated techniques play a key role in the synthesis of new chemical entities. More compounds, less time = Cost effective Summary 27
  • 28. MITSUBISHI ELECTRI SCARA ROBOT RH-6SH RH-6SDH.flv Epson has 3 types of robots, Scara, Cartesian, & 6 axis.flv 28
  • 29. References 1)DENSORobotics-Selecting Robots for Use in Drug Discovery and Testing 2) Medicinal Chemistry & Drug Discovery, Dr. Peter Wipf Department of Chemistry University of Pittsburgh http://ccc.chem.pitt.edu/wipf/index.html 3) AMRI-Drug Discovery and Development: Applications of Robotics and High-Throughput Instrumentation Brian T. Gregg, Ph.D. Research Fellow Medicinal Chemistry, June 25, 2007 29
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