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Author(s): Rebecca W. Van Dyke, M.D., 2012

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Introduction


              Introduction to M2 GI Sequence
                 Rebecca W. Van Dyke, MD




Winter 2012
Industry Relationship Disclosures
 Industry Supported Research and
      Outside Relationships
• None
Learning Objectives
•   1. Students will describe tools to evaluate the GI tract.

•   2. Students will view endoscopic pictures and videos (available
    on line) as a tour of the GI tract.

•   3. Students will describe specialized forms of endoscopy
    (capsule endoscopy, double-balloon endoscopy)

•   4. Students will describe principles of GI motility from
    educational video on the subject which they will view on line.
The GI Tract:
Multiple organs and endogenous
         flora (bacteria)




       Pearson Scott Foresman, Wikimedia Commons
Address to a Haggis
                                             Robert Burns

Fair fa’ your honest sonsie face
Great chieftain o’ the pudding race…

The groaning trencher there ye fill
Your hirdies like a distant hill…..

But mark the Rustic, haggis-fed
The trembling earth resounds his tread……

Ye Pow’rs wha mak mankind your care;
And dish them out their bill o’fare
Auld Scotland wants nae skinking ware That jaups in luggies;
But, if ye wish her gratefu’ prayer, Gie her a haggis!
       Robert Burns, “Address to a Haggis,” 1786.
Course Information


•   Course content/MDC
•   Syllabus and information about the course
•   Web sites for additional materials
•   Introduction to Gastroenterology
•   Morning question/problem periods
M2 GI Sequence Jan 25-Feb 10, 2012



Your syllabus has the complete course schedule and it is also posted on-line.

Please check for your small group and pathology lab assignments as well.

We will work through modules:
  1. Stomach/esophagus: esophagitis, peptic ulcer disease
  2. Motility disorders of the tubular GI tract
  3. Small intestine/colon: diarrhea, inflammatory bowel disease, cancer
  4. Abdominal pain
  5. Liver physiology and disease
  6. GI cancers: pancreatic, colorectal
  7. Pancreatic disease
  8. GI bleeding and miscellaneous topics
  9. Nutrition
  10. Introduction to ENT (otolaryngology)
Web-Based Information
• PowerPoint presentations of
  lectures are available on-line as are
  streaming videos.
• Copy of GI Pathology lab syllabus
  will also be put on on-line
• Copy of Pathology Slide Guide is
  found at:
• http://www.med.umich.edu/lrc/students/m2/gastrointestinal/i
GAS608 Final Exam
     (3 hour course exam and 1 hour pathology exam)

Online access Friday Feb 10, 5:00 p.m. – Sign-on deadline
       for both exams: Sunday Feb 12, 10:00 p.m..

Queries due by during the week after the exam. Exact times
                      will be posted.
Tools for Evaluating the GI Tract
Capsule endoscopy                          Endoscopy




    Euchiasmus,
    Wikimedia Commons                      - Biopsy
Radiology                                  - Endoscope




    jcjack, Flickr      brainsik, Flickr
Dr. Basil Hirschowitz and an early fiberoptic
 endoscope at the University of Michigan
Tour of the Lumen of the Tubular
Gastrointestinal Tract: Structures
 Within Reach of the Endoscope

         A Lumen with a View
Normal Vocal Cords


                                   Vocal
                                   cord




Entrance to
esophagus
Normal Esophagus
A Funny Thing Happened on the Way to the Stomach
Retroflex View of Gastro-
   esophageal Junction from inside
            the stomach
Endoscope
Normal Stomach
Large rugal folds of proximal stomach
               (fundus)
Normal Distal Stomach/Antrum
Strange Encounters of the Endoscopic Kind
Normal Antrum (foreground) and
           Pylorus
Normal Duodenum
Not distended so valvulae conniventes appear
                  thickened
External View of Normal Anus
Retroflex View of Anus/Anal
Sphincter from inside the colon
Normal Rectum
prominent vasculature
Sigmoid Colon
Descending Colon (left side)
Splenic Flexure of Colon
Transverse Colon
characteristic triangular folds
Transverse Colon
Hepatic Flexure of Colon
Ascending Colon (right side)




Haustral
Folds
Cecum


Ileocecal
Valve
Close-up of Ileocecal Valve in the
              Cecum
Ileum as viewed after passing through
   the ileocecal valve from the colon




                            Valvulae
                            conniventes
Endoscopy

• View from mouth to mid-duodenum
  – Upper endoscopy
  – EGD = esophagogastroduodenoscopy
• View from anus to cecum/terminal ileum
  – Lower endoscopy
  – Colonoscopy
• What does this leave?
  – Small bowel
  – Capsule endoscopy
Capsule can be used to
                                   easily visualize rest of the
                                   small intestine.




Extent of
esophagogastroduodenoscopy        Extent of push
                                  endoscopy (80-120
                                  cm past ligament of
                                  Trietz).
                                  Uncomfortable and
                                  time-consuming.



                             Extent of
                             colonoscopy
Capsule endoscopy
Double Balloon Endoscopy
Capsule Views
normal small bowel




                     Lymphoid hyperplasia
Capsule Views
                     Diseases




Ulcers from Crohn’s disease or non-steroidal anti-inflammatory
                       Drugs (NSAIDs)
Capsule Views
             Disease




Bleeding    Arteriovenous    Stricture
            Malformation    (NSAIDs)
                (AVM)
Further images and endoscopic videos
          of GI/Liver diseases
• daveproject.org/

• This is a free website established and
  updated by gastroenterologists and
  sponsored by the American Society of
  Gastrointestinal Endoscopists and one of the
  endoscopy equipment manufacturers

• Feel free to wander…….
Videos

• Animations of upper and lower endoscopy
• Examples of normal endoscopy – these will
  be posted on CTools
• GI motility video – physiology and
  pathophysiology. This is about 30 minutes in
  regular speed. It is on CTools and I suggest
  you watch it at the usual 1.5-2x speed.
Additional Source Information
                                  for more information see: http://open.umich.edu/wiki/CitationPolicy

Slide 6, Image 1 (left): Pearson Scott Foresman, "Intestine," Wikimedia Commons, http://commons.wikimedia.org/wiki/File:Intestine_(PSF).png.
Slide 12, Image 1 (left, top): Euchiasmus, "CapsuleEndoscope", Wikimedia Commons, http://commons.wikimedia.org/wiki/File:CapsuleEndoscope.jpg.
Slide 12, Image 3 (left, bottom): jcjack, "Radiology 2-R," Flickr, http://www.flickr.com/photos/48497052@N04/5058467485/#/, CC: BY 2.0,
   http://creativecommons.org/licenses/by/2.0/deed.en
Slide 12, Image 4 (middle, bottom): brainsik, "CAT scan sofa," Wikimedia Commons,
   http://www.flickr.com/photos/brainsik/168596881/sizes/z/in/photostream/, CC: BY 2.0, http://creativecommons.org/licenses/by/2.0/deed.en

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01.25.12: Introduction to M2 GI Sequence

  • 1. Author(s): Rebecca W. Van Dyke, M.D., 2012 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution – Share Alike 3.0 License: http://creativecommons.org/licenses/by-sa/3.0/ We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact open.michigan@umich.edu with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use. Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition. Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.
  • 2. Attribution Key for more information see: http://open.umich.edu/wiki/AttributionPolicy Use + Share + Adapt { Content the copyright holder, author, or law permits you to use, share and adapt. } Public Domain – Government: Works that are produced by the U.S. Government. (17 USC § 105) Public Domain – Expired: Works that are no longer protected due to an expired copyright term. Public Domain – Self Dedicated: Works that a copyright holder has dedicated to the public domain. Creative Commons – Zero Waiver Creative Commons – Attribution License Creative Commons – Attribution Share Alike License Creative Commons – Attribution Noncommercial License Creative Commons – Attribution Noncommercial Share Alike License GNU – Free Documentation License Make Your Own Assessment { Content Open.Michigan believes can be used, shared, and adapted because it is ineligible for copyright. } Public Domain – Ineligible: Works that are ineligible for copyright protection in the U.S. (17 USC § 102(b)) *laws in your jurisdiction may differ { Content Open.Michigan has used under a Fair Use determination. } Fair Use: Use of works that is determined to be Fair consistent with the U.S. Copyright Act. (17 USC § 107) *laws in your jurisdiction may differ Our determination DOES NOT mean that all uses of this 3rd-party content are Fair Uses and we DO NOT guarantee that your use of the content is Fair. To use this content you should do your own independent analysis to determine whether or not your use will be Fair.
  • 3. Introduction Introduction to M2 GI Sequence Rebecca W. Van Dyke, MD Winter 2012
  • 4. Industry Relationship Disclosures Industry Supported Research and Outside Relationships • None
  • 5. Learning Objectives • 1. Students will describe tools to evaluate the GI tract. • 2. Students will view endoscopic pictures and videos (available on line) as a tour of the GI tract. • 3. Students will describe specialized forms of endoscopy (capsule endoscopy, double-balloon endoscopy) • 4. Students will describe principles of GI motility from educational video on the subject which they will view on line.
  • 6. The GI Tract: Multiple organs and endogenous flora (bacteria) Pearson Scott Foresman, Wikimedia Commons
  • 7. Address to a Haggis Robert Burns Fair fa’ your honest sonsie face Great chieftain o’ the pudding race… The groaning trencher there ye fill Your hirdies like a distant hill….. But mark the Rustic, haggis-fed The trembling earth resounds his tread…… Ye Pow’rs wha mak mankind your care; And dish them out their bill o’fare Auld Scotland wants nae skinking ware That jaups in luggies; But, if ye wish her gratefu’ prayer, Gie her a haggis! Robert Burns, “Address to a Haggis,” 1786.
  • 8. Course Information • Course content/MDC • Syllabus and information about the course • Web sites for additional materials • Introduction to Gastroenterology • Morning question/problem periods
  • 9. M2 GI Sequence Jan 25-Feb 10, 2012 Your syllabus has the complete course schedule and it is also posted on-line. Please check for your small group and pathology lab assignments as well. We will work through modules: 1. Stomach/esophagus: esophagitis, peptic ulcer disease 2. Motility disorders of the tubular GI tract 3. Small intestine/colon: diarrhea, inflammatory bowel disease, cancer 4. Abdominal pain 5. Liver physiology and disease 6. GI cancers: pancreatic, colorectal 7. Pancreatic disease 8. GI bleeding and miscellaneous topics 9. Nutrition 10. Introduction to ENT (otolaryngology)
  • 10. Web-Based Information • PowerPoint presentations of lectures are available on-line as are streaming videos. • Copy of GI Pathology lab syllabus will also be put on on-line • Copy of Pathology Slide Guide is found at: • http://www.med.umich.edu/lrc/students/m2/gastrointestinal/i
  • 11. GAS608 Final Exam (3 hour course exam and 1 hour pathology exam) Online access Friday Feb 10, 5:00 p.m. – Sign-on deadline for both exams: Sunday Feb 12, 10:00 p.m.. Queries due by during the week after the exam. Exact times will be posted.
  • 12. Tools for Evaluating the GI Tract Capsule endoscopy Endoscopy Euchiasmus, Wikimedia Commons - Biopsy Radiology - Endoscope jcjack, Flickr brainsik, Flickr
  • 13. Dr. Basil Hirschowitz and an early fiberoptic endoscope at the University of Michigan
  • 14. Tour of the Lumen of the Tubular Gastrointestinal Tract: Structures Within Reach of the Endoscope A Lumen with a View
  • 15. Normal Vocal Cords Vocal cord Entrance to esophagus
  • 17. A Funny Thing Happened on the Way to the Stomach
  • 18. Retroflex View of Gastro- esophageal Junction from inside the stomach Endoscope
  • 19. Normal Stomach Large rugal folds of proximal stomach (fundus)
  • 21. Strange Encounters of the Endoscopic Kind
  • 23. Normal Duodenum Not distended so valvulae conniventes appear thickened
  • 24. External View of Normal Anus
  • 25. Retroflex View of Anus/Anal Sphincter from inside the colon
  • 30.
  • 34. Ascending Colon (right side) Haustral Folds
  • 36. Close-up of Ileocecal Valve in the Cecum
  • 37. Ileum as viewed after passing through the ileocecal valve from the colon Valvulae conniventes
  • 38. Endoscopy • View from mouth to mid-duodenum – Upper endoscopy – EGD = esophagogastroduodenoscopy • View from anus to cecum/terminal ileum – Lower endoscopy – Colonoscopy • What does this leave? – Small bowel – Capsule endoscopy
  • 39. Capsule can be used to easily visualize rest of the small intestine. Extent of esophagogastroduodenoscopy Extent of push endoscopy (80-120 cm past ligament of Trietz). Uncomfortable and time-consuming. Extent of colonoscopy
  • 42. Capsule Views normal small bowel Lymphoid hyperplasia
  • 43. Capsule Views Diseases Ulcers from Crohn’s disease or non-steroidal anti-inflammatory Drugs (NSAIDs)
  • 44. Capsule Views Disease Bleeding Arteriovenous Stricture Malformation (NSAIDs) (AVM)
  • 45. Further images and endoscopic videos of GI/Liver diseases • daveproject.org/ • This is a free website established and updated by gastroenterologists and sponsored by the American Society of Gastrointestinal Endoscopists and one of the endoscopy equipment manufacturers • Feel free to wander…….
  • 46. Videos • Animations of upper and lower endoscopy • Examples of normal endoscopy – these will be posted on CTools • GI motility video – physiology and pathophysiology. This is about 30 minutes in regular speed. It is on CTools and I suggest you watch it at the usual 1.5-2x speed.
  • 47. Additional Source Information for more information see: http://open.umich.edu/wiki/CitationPolicy Slide 6, Image 1 (left): Pearson Scott Foresman, "Intestine," Wikimedia Commons, http://commons.wikimedia.org/wiki/File:Intestine_(PSF).png. Slide 12, Image 1 (left, top): Euchiasmus, "CapsuleEndoscope", Wikimedia Commons, http://commons.wikimedia.org/wiki/File:CapsuleEndoscope.jpg. Slide 12, Image 3 (left, bottom): jcjack, "Radiology 2-R," Flickr, http://www.flickr.com/photos/48497052@N04/5058467485/#/, CC: BY 2.0, http://creativecommons.org/licenses/by/2.0/deed.en Slide 12, Image 4 (middle, bottom): brainsik, "CAT scan sofa," Wikimedia Commons, http://www.flickr.com/photos/brainsik/168596881/sizes/z/in/photostream/, CC: BY 2.0, http://creativecommons.org/licenses/by/2.0/deed.en