The primary difference between active transport and facilitated diffusion is that active transport is the only one of the two in which the direction of transport is [S]_low rightarrow [S]_high the direction of transport is- [S]high rightarrow [S]_low transporter proteins are required the mechanism is not storable the S concentration grade provides the energy necessary for S transport Solution The answer for the above question is : the direction of transport is [S] low to [S] high. The active transport is different from facilitated transport because it uses energy to move the molecules AGAINST the concentration gradient i.e., from a region of lower concentration to the region of higher concentration. We can take the example of intestines, where the concentration of nutrients are already very high in the cells..