This poster is presented in national level e-poster competition..This poster includes epidemiology and pathophysiology of Corona virus

1. Corona virus disease:Pathophysiology and Epidemiology
C.Pon Manisha* , S.Mathivanan, M.Asiyabi, K.B.Ilango
Department of Pharmacy, Shree Venkasteshwara College of Paramedical Sciences
(Affiliated to The Tamil Nadu Dr.M.G.R.Medical University, Chennai)
Address : Erode—Gobi main road, Othakuthirai, Gobi. Erode DT , Tamilnadu—638455
Introduction
Pathophysiology
An outbreak of a respiratory disease began in Wuhan, China in December
2019 and the caustive agent was discovered in January 2020.
A novel beta coronavirus of the same subgenus as SARs - CoV and
named severe acute respiratory syndrome cronavirus - 2 (SARS-CoV-2).
Corona virus is one of the major pathogen that primarily target human
respiratory system.
Epidemiology
When the virus enter the respiratory system of alveoli,CoVID-19 virus mainly
adapt type-2 pneumocytes.
The spike protein binds to ACE2 (angiotensin converting enzyme 2 ),as soon as
the virus enter the cells it release single stranded RNA.
As the virus damage the type-2 pneumocytes and release inflammatory mediators
to activate alveolar macrophage.
The macrophage release specific cytokines like IL-1,IL-6,TNF and it cause
vasodilation and increased capillary permiability.
So the consequence of plasma will spread in the interstitial space so it accumulate
and compress alveoli.
Some fluid comes into alveoli which eventually leads to alveolar collapse.
Alveolar collapse decrease gas exchange which cause Hypoxemia.
There will be capillary permiability all over the body ,the fluid will go out the
body interstitial space which leads decrease blood volume and decrease peripheral
resistance leads to Hypotension.
The final outcome multiple organ failure.
COVID-19 is caused by the virus SARS-CoV-2s.
 SARS-CoV-2 spreads from person to person through close contact(6 feet).
People with COVID-19 breathe out or cough, they expel tiny droplets that contain
the virus.
 These droplets can enter the mouth or nose of someone without the virus, causing
an infection to occur.
Infection with COVID-19 appears in December 2019 in china.
It seems to be February 16,2020 there have been 51,174 people who have
contracted the infection and more than 1666 people have died.
Safety Precautions
Follow the directions of your local health authority.
Conclusion
Stay home.
Wash hands often with soap or alcohol based hand rub.
Keep a safe distance from anyone who is coughing or sneezing.
Cover your cough or sneeze with a tissue or bent elbow.
There has been a rapid surge in research in response to the outbreak of
COVID-19.During this early primarily explored the pathophysiology,
epidemiology, causes, objectives and discussion of the novel coronavirus.
Although these studies are relevant to current public emergency in both
short- and long-term.
Morphology
Corona viruses are enveloped indicating that they are lipid
soluble.
They are carrying crown like peplomer spikes.
They are +ve single stranded RNA genome.
The size of the virus is 100-160nm and helical symmetry.
Prepared for the National level e-poster presentation on “COMBAT AND CONQUER COVID-19” organised by Periyar College of Pharmaceutical sciences, Sathanoor main road, Tiruchirappalli - 620 021.