Technology Snapshot for Whiteboard2Boardroom on February 27, 2018.

1. Nanoparticles for
Endotoxin Filtration
2/27/18

2. What is the problem?
• Endotoxins, a lipopolysaccharide (LPS) on
the outer membrane of bacteria, play a
key role in the process of septic shock in
the body. Septic shock is a leading cause
of death in ICUs.

3. How does product/service solve problem?
• Polymeric nanoparticles (NP) readily bind to
endotoxin, which makes them a perfect tool for
endotoxin filtration, and therefore able to reduce or
prevent unneeded deaths.

4. What is the market use?
• Water filtration
• Dialysis water filtration
• Pharmaceutical product
filtration
• Tissue culture
purification

5. What competition exists?
• Merck Millipore:
Pellican®, Prostak®,
Charged Durapore®, …
• Pall Corporation:
Acrodisc®, Mustang® E
Membrane

6. What is the status of the intellectual property?
• Patent issued: 15/130,564 – NOA 1/5/2018
– Filed 4/15/2016
• No office actions, allowed as filed
• Divisional application in process:
– 15/130,544; 4/15/2016, “Polymer-Coated
Therapeutic Nanoparticles”

7. What is the stage of development?
• Our reliable and simple NP method to filter
endotoxins using an easy and scalable
method is ready for commercialization.

8. What is needed for further development?
• Additional optimization and research can be done
with:
– Further development of polymeric NP
– Optimization of minimum endotoxin levels
– Isothermal titration calorimetry experiment to further
suggest binding of polymeric NP to endotoxin
– Implementing polymeric NP to existing filtration systems