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Micro- & NanoEncapsulation Services in the Catalan Institute of Nanotechnology
- 2. Catalan Institute of Nanotechnology Supramolecular NanoChemistry & Materials Group Micro- & Nanoencapsulation Services Presentation About us
- 3. Catalan Institute of Nanotechnology (ICN) The Catalan Institute of Nanotechnology (ICN) is a non-profit private foundation created in 2003 by the Ministry of Universities, Research and Information Society of the Catalan Government (DIUE) and the Autonomous University of Barcelona (UAB). It is part of CERCA, the network of Research Centres launched by the Catalan Government as a cornerstone of its long-term strategy to foster development of a knowledge- based economy. ICN's research lines focus on the newly discovered physical and chemical properties that arise from the fascinating behaviour of matter at the nanoscale.
- 4. Supramolecular NanoChemistry & Materials The Supramolecular NanoChemistry & Materials (NANOup) group was set up in 2009 by ICREA Research Prof Daniel Maspoch. It comprises 5 senior researchers, 6 PhD students and 1 project manager. NANOup uses supramolecular chemistry to explore new materials and applications (in close collaboration with several private companies) in diverse areas, including micro- and nanoencapsulation, drug-delivery systems, contrast agents, and novel sensors and magnetic platforms.
- 5. Carlos Carbonell Contracted PhD Marta Rubio ICN Fellow Marta González Project Manager Dr. Sonia García Contracted Post-Doc Dr. Nereida Mejías Senior Technician Àngels Ruyra Ramón Areces Fellow ICREA Prof. Daniel Maspoch Group Leader Dr. Inhar Imaz RyC Researcher Dr. Mary Cano Researcher Dr. Kyriakos Stylianou Marie Curie Fellow Iván Burneo SENESCYT Fellow Arnau Carné FI Fellow Javier Ariñez FPU Fellow NANOup team
- 7. Packaging micro- or nanoparticles of solid, liquid or gas (the core or active substance) within a secondary material (the matrix or shell), to form nano- or microcapsules Micro- and Nanoencapsulation Technologies The core material is protected by a shell and only delivered when needed. Triggered release (pH, T, pressure) Target release (site recognition) Sustained release (shell decomposition)
- 8. Functional advantages Protect core material Change properties (increase solubility, mask taste, etc.) Reduce costs Decrease toxicity (reduce required dose; local release) Aesthetic improvements
- 9. Micro- & Nanoencapsulation Services To help private companies and public research institutes to develop novel encapsulation products Our mission: we provide a complete product development service
- 10. Design From the lab to the market: Development Quality Control We design and fabricate new products, based on in-house technology, and assist collaborators with scaling-up. Scale-up to Commercial Quantitites
- 11. Our expertise Core Hydrophobic liquids Aqueous solutions Solids Emulsions Dispersions Gases Shell Polymers: natural (polysaccharides, proteins, etc.), synthetic (polyamides, polyesters, polyureas, polyurethanes, urea/melamine -formaldehyde resin, polystyrene, etc.), semi synthetic (chitosan, cellulose, starch, etc.) Lipids: cholesterol, phospholipids Inorganic materials: SiO2 We have developed diverse types of micro- and nanocapsules to match each industrial sector and application. These differ by their membrane, which is carefully selected to suit the customer’s needs. Depending on the final application, the membrane can be further optimised.
- 12. • Prevent environmental oxidation or deactivation • Separate incompatible materialsProtect core material • Mask organoleptic properties like color, taste, odor of substances • Safe handling of toxic cores Modify properties of the core material • Reduce handling costs Convert liquids to free- flowing solids • Improve adhesion, penetration or recognition of tissues and cells • Reduce active doses, and therefore, potential toxicity/side-effects Controlled and targeted release of encapsulated cores • Provide sustained release maintain optimal concentration • Provide triggered release based on environmental changes (T, pH) • Marketing & product aesthetics Modify core material via release • Enable more stable, efficient and biocompatible products, based on nanocapsulesDevelop novel products
- 13. We can encapsulate core materials in different polymer membranes. Encapsulation protects the active component in the core, enables controlled release and reduces or eliminates toxicity. Our capabilities +
- 14. In-situ, interfacial & radical polymerisation • Melamine-formaldehyde, polyurethane, styrene, polyurea, polyamides, polyesters, silica, ethylcellulose Simple and complex coacervation • Gelatin, acacia and glutaraldehyde • Casein, chitosan, PVA Liposomes & Solid Lipid Nanoparticles • Lipid-cake hydration and homogeneisation by extrusion, ultrasound • Emulsions • Nanoemulsions, double emulsions • Polymeric surfactants Spray-drying • Particle miniaturisation (300 nm to 100µm) • Encapsulate peptides, drugs or food ingredients
- 15. Our equipment Through specialised facilities—some of which are unique in Spain—we offer high-level technical assistance to collaborate with external partners, including for commercial R&D. Equipment for synthesis Pilot plant Characterisation
- 16. Nanochemistry Lab Rotary evaporator Freezer (-80 ºC) Lyophiliser Ultracentrifuge Spray-drying Nanospray Spray Drier (Büchi) Mini Spray Drier (Büchi) Particle miniaturisation Extrusion LIPEXTM extruder (Northern Lipids) Liposome preparation at 10 mL scale
- 17. High pressure homogenisation M-110L Microfluidiser Processor High-shear fluids processing Microfluidics Pilot plant reactor Dispermat CN 0.5 to 40 L Dissolver Bench scale mixers Overhead stirrers Ultraturrax (IKA) Ultrasound probe
- 18. Stability studies Turbiscan Mastersizer Direct Visualisation SEM TEM Cryo-TEM Rupture force & deformability studies Nanoindentator Full physical characterisation Viscosimeter Full chemical characterisation IR, UV, Elemental analysis, EDX, TOF-SIMS, X-ray powder diffraction Study of the release Porosity studies BET Size determination DLS SEM 4 m
- 19. Custom solutions With extensive experience and knowledge in the microencapsulation field, we can solve your technical problems in any industrial sector. We can help you to protect solid particles or liquid droplets and ensure controlled release of the active components.
- 20. Agriculture Textiles Construction Nutrition Drugs Cosmetics Nanotechnology does not always involve expensive equipment or rare materials: it can often be incorporated into existing industrial processes with minimal capital investment.
- 21. Fragrance encapsulation for detergents and softeners Biocide encapsulation for paintings Disinfectant encapsulation for clinical surfaces disinfection Enzymatic encapsulation Peptide micronisation Capsules for self-repairing wood Development of encapsulating matrices using metal-organic systems Encapsulation of phage & inmunostimulants in liposomes and in polysaccharide & biocompatible polymers We are already working with several companies to develop new commercial products and techniques that incorporate Nanotechnology:
- 22. Thank you for your attention! Group Leader, NANOUP daniel.maspoch@icn.cat Micro- and Nanoencapsulation Technologies Leader, NANOUP mary.cano@icn.cat Questions on encapsulation? Feel free to contact us!