High shear granulation is a shaping process for granulation that has been enhanced for application in the pharmaceutical industry. A binder liquid is fed to the powder particles in a closed container with blending tools and a chopper. Dense granules are formed through the liquid and solid bridges that result.
2. Contents
• Introduction of RMG
• Construction & Major Components
• Process Flow Diagram
• Gansons HSRMG Benefits & Technology
• Production Range
• Principals For RMG
• Competitors In The Market
• Market Reference For RMG
3. HSRMG - A Production Solution for Solid Dose
Uniform Mixing
Content Homogeneity
Wet Granulation
Introducing
50 Years Development & Research
Patented Technology
With 250+ RMG Solution Including Europe, Asia & Worlwide
18 Tons Per Day Granulation Output
4. Construction & Major Components:
1. Body
2. Loading Port
3. Blending Solution Inlet
4. Impeller
5. Chopper
6. Discharge Port
Other Components:
Sampling Port
View Panel
Human Monitoring Interface
Wet Mill(Generally Attached With RMG)
5. Process Flow Diagram- After Loading
End Point Detection:
Dry Mixing
Wet Mixing
Discharge
It can be done manually using poly bags, using SS containers or using
Vacuum Suction(VTS)
Dry Mixing operation is required for uniform mixing of all Powdered
materials to achieve content uniformity
Binder Solution(can be added manually or Peristaltic Pump), Water,
Paste(Requires High Suction Pump-
Lobe Pump) added here to form Granule.
Reaching End point, a pneumatic discharge port(3-6 Bars) opens up at
the Bottom of the RMG.
5-10
Mins
10-15
Mins
3-5 Mins
1-15
Mins
6.
7. Gansons HSRMG Technology
The Gansons High Shear Mixer Granulator offers solutions to these
operational concerns.
Ganson’s ensures required quality to oparate SS material to ensure
Consistent Machine Operation.
Unique Impeller design significantly improves pre-mixing efficiency
No uncertainty : Precise and accurate scalability
Electro-mechanical components provide consistently reliable end-
point detection.
The electro-mechanical drive system provides significantly higher
energy efficiency versus
conventional RMGs.
Gansons proprietary mechanical seal prevents the entry of any
particles.
The Gansons IMPELIFT* system raises the bottom impeller for
ease of cleaning.
8. • The Shape of the RMG & Its components
• Optimized Diffusion, Convection & 3D Shear
• Unique Beveled Impeller Design
• Close Tolerance
• The Scalability
• End Point Detection
• Cleaning & Validation
• Value Added Features
Why Gansons:
9. Production Range:
Capacity:
Capacity of a RMG can be manufactured 3 Scales of
Production, i.e.,
R&D Scale- 1L- 10L
Pilot Scale- 20L- 60L
Commercial Production Scale: 60L- 800L**(Bulk
Density Considered .5kg/ltr)
We capable of Supplying Customized capped
Machine from our Suppliers.
10. Gansons & Excelsior Offers:
1. Gansons HSMG, a developed version of RMG, with a lot of
Technological advantages like high throughput, precise technology,
control system.
2. Manufacturing of the Machine matching the regulations and Quality
3. Cost compatibility, Option to compete with existing Competitors
4. Low Shipment time and Low distance from Bangladesh, available
spares.
5. Strong Service Team to follow up with any Service Issue.
6. Documentation Quality and Technical Support with the RMG.
7. Pricing can be optimized and quality can be developed by changing
component sources i.e.: PLC, Siemens Germany/ Siemens India,
Mitsubishi Japan/ Mitsubishi China
8. Strong Market Reference Like Square, ACI, Ziska & ACME.
9. Excelsior's Quality and Market Reference.