This document contains a series of questions and answers about antimicrobial drugs and antibiotic resistance. It is formatted as a quiz with multiple choice questions on topics like the history of antibiotic discovery, modes of antibiotic action, resistance development, and strategies for combating resistance. The questions progress from $100 to $500 in value and cover five main topics: history, antimicrobials, mode of action, resistance, and the future of antimicrobial drugs.

1. Bradley W. Christian, McLennan Community College
© 2016 Pearson Education, Inc.
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Chapter 20: Antimicrobial Drugs
History Antimicrobials
Mode of
Action
Today and
the Future
Resistance
FINAL ROUND

2. © 2016 Pearson Education, Inc.
Topic 1: History
$100 Question
The birth of modern chemotherapy is credited
to the efforts of
a. Alexander Fleming.
b. Paul Ehrlich.
c. Robert Koch.
d. Louis Pasteur.
ANSWER
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3. © 2016 Pearson Education, Inc.
Topic 1: History
$100 Answer
The birth of modern chemotherapy is credited
to the efforts of
a. Alexander Fleming.
b. Paul Ehrlich.
c. Robert Koch.
d. Louis Pasteur.
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4. © 2016 Pearson Education, Inc.
Topic 1: History
$200 Question
In 1928, who observed that the growth of bacteria
was inhibited on a Petri plate contaminated by a
mold?
a. Alexander Fleming
b. Paul Ehrlich
c. Robert Koch
d. Louis Pasteur
ANSWER
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5. © 2016 Pearson Education, Inc.
Topic 1: History
$200 Answer
In 1928, who observed that the growth of bacteria
was inhibited on a Petri plate contaminated by a
mold?
a. Alexander Fleming
b. Paul Ehrlich
c. Robert Koch
d. Louis Pasteur
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6. © 2016 Pearson Education, Inc.
Topic 1: History
$300 Question
What was the FIRST antibiotic discovered?
a. tetracycline
b. erythromycin
c. streptomycin
d. penicillin
ANSWER
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7. © 2016 Pearson Education, Inc.
Topic 1: History
$300 Answer
What was the FIRST antibiotic discovered?
a. tetracycline
b. erythromycin
c. streptomycin
d. penicillin
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8. © 2016 Pearson Education, Inc.
Topic 1: History
$400 Question
In World War II, which of the following made it
clear that antimicrobial agents could be effective
against systemic bacterial infections?
a. sulfa drugs
b. penicillin
c. tetracycline
d. erythromycin
ANSWER
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9. © 2016 Pearson Education, Inc.
Topic 1: History
$400 Answer
In World War II, which of the following made it
clear that antimicrobial agents could be effective
against systemic bacterial infections?
a. sulfa drugs
b. penicillin
c. tetracycline
d. erythromycin
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10. © 2016 Pearson Education, Inc.
Topic 1: History
$500 Question
More than half of our antibiotics are produced by
species of
a. Mycobacterium.
b. Streptomyces.
c. Clostridium.
d. Bacillus.
ANSWER
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11. © 2016 Pearson Education, Inc.
Topic 1: History
$500 Answer
More than half of our antibiotics are produced by
species of
a. Mycobacterium.
b. Streptomyces.
c. Clostridium.
d. Bacillus.
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12. © 2016 Pearson Education, Inc.
Topic 2: Antimicrobials
$100 Question
Which of the following are the easiest to treat with
antimicrobial agents?
a. viruses
b. fungi
c. bacteria
d. protozoa
ANSWER
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13. © 2016 Pearson Education, Inc.
Topic 2: Antimicrobials
$100 Answer
Which of the following are the easiest to treat with
antimicrobial agents?
a. viruses
b. fungi
c. bacteria
d. protozoa
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14. © 2016 Pearson Education, Inc.
Topic 2: Antimicrobials
$200 Question
One disadvantage to using broad-spectrum
antibiotics is that they
a. destroy normal microbiota.
b. are easily inactivated by the host.
c. are extremely toxic.
d. target host cells.
ANSWER
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15. © 2016 Pearson Education, Inc.
Topic 2: Antimicrobials
$200 Answer
One disadvantage to using broad-spectrum
antibiotics is that they
a. destroy normal microbiota.
b. are easily inactivated by the host.
c. are extremely toxic.
d. target host cells.
BACK TO GAME

16. © 2016 Pearson Education, Inc.
Topic 2: Antimicrobials
$300 Question
Practically ALL antibiotic-producing microbes
have a(n) ________ process.
a. toxin-producing
b. sporulation
c. motility
d. encapsulation
ANSWER
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17. © 2016 Pearson Education, Inc.
Topic 2: Antimicrobials
$300 Answer
Practically ALL antibiotic-producing microbes
have a(n) ________ process.
a. toxin-producing
b. sporulation
c. motility
d. encapsulation
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18. © 2016 Pearson Education, Inc.
Topic 2: Antimicrobials
$400 Question
If an antibiotic prevents bacteria from growing,
then its action is termed
a. bactericidal.
b. selectively toxic.
c. bacteriostatic.
d. toxic.
ANSWER
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19. © 2016 Pearson Education, Inc.
Topic 2: Antimicrobials
$400 Answer
If an antibiotic prevents bacteria from growing,
then its action is termed
a. bactericidal.
b. selectively toxic.
c. bacteriostatic.
d. toxic.
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20. © 2016 Pearson Education, Inc.
Topic 2: Antimicrobials
$500 Question
Which of the following antimicrobials has the
broadest spectrum of activity?
a. streptomycin
b. isoniazid
c. penicillin G
d. tetracycline
ANSWER
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21. © 2016 Pearson Education, Inc.
Topic 2: Antimicrobials
$500 Answer
Which of the following antimicrobials has the
broadest spectrum of activity?
a. streptomycin
b. isoniazid
c. penicillin G
d. tetracycline
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22. © 2016 Pearson Education, Inc.
Topic 3: Mode of Action
$100 Question
Penicillin works by inhibiting ________ synthesis.
a. protein
b. cell wall
c. plasma membrane
d. nucleic acid
ANSWER
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23. © 2016 Pearson Education, Inc.
Topic 3: Mode of Action
$100 Answer
Penicillin works by inhibiting ________ synthesis.
a. protein
b. cell wall
c. plasma membrane
d. nucleic acid
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24. © 2016 Pearson Education, Inc.
Topic 3: Mode of Action
$200 Question
Eukaryotes have 80S ribosomes whereas
prokaryotes have ________ ribosomes.
a. 90S
b. 80S
c. 70S
d. 60S
ANSWER
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25. © 2016 Pearson Education, Inc.
Topic 3: Mode of Action
$200 Answer
Eukaryotes have 80S ribosomes whereas
prokaryotes have ________ ribosomes.
a. 90S
b. 80S
c. 70S
d. 60S
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26. © 2016 Pearson Education, Inc.
Topic 3: Mode of Action
$300 Question
The relationship between the antimetabolite
sulfanilamide and para-aminobenzoic acid
(PABA) is an example of
a. antagonism.
b. competitive inhibition.
c. synergism.
d. bacteriostasis.
ANSWER
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27. © 2016 Pearson Education, Inc.
Topic 3: Mode of Action
$300 Answer
The relationship between the antimetabolite
sulfanilamide and para-aminobenzoic acid
(PABA) is an example of
a. antagonism.
b. competitive inhibition.
c. synergism.
d. bacteriostasis.
BACK TO GAME

28. © 2016 Pearson Education, Inc.
Topic 3: Mode of Action
$400 Question
The mode of action of chloramphenicol is to
a. inhibit cell wall synthesis.
b. inhibit nucleic acid synthesis.
c. injure the plasma membrane.
d. inhibit protein synthesis.
ANSWER
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29. © 2016 Pearson Education, Inc.
Topic 3: Mode of Action
$400 Answer
The mode of action of chloramphenicol is to
a. inhibit cell wall synthesis.
b. inhibit nucleic acid synthesis.
c. injure the plasma membrane.
d. inhibit protein synthesis.
BACK TO GAME

30. © 2016 Pearson Education, Inc.
Topic 3: Mode of Action
$500 Question
The mode of action of antifungal drugs that target
sterols is to
a. inhibit the synthesis of essential metabolites.
b. injure the plasma membrane.
c. inhibit nucleic acid synthesis.
d. inhibit cell wall synthesis.
ANSWER
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31. © 2016 Pearson Education, Inc.
Topic 3: Mode of Action
$500 Answer
The mode of action of antifungal drugs that target
sterols is to
a. inhibit the synthesis of essential metabolites.
b. injure the plasma membrane.
c. inhibit nucleic acid synthesis.
d. inhibit cell wall synthesis.
BACK TO GAME

32. © 2016 Pearson Education, Inc.
Topic 4: Resistance
$100 Question
Bacteria that are resistant to large numbers of
antibiotics are popularly termed
a. superbugs.
b. superinfections.
c. MRSA.
d. mutants.
ANSWER
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33. © 2016 Pearson Education, Inc.
Topic 4: Resistance
$100 Answer
Bacteria that are resistant to large numbers of
antibiotics are popularly termed
a. superbugs.
b. superinfections.
c. MRSA.
d. mutants.
BACK TO GAME

34. © 2016 Pearson Education, Inc.
Topic 4: Resistance
$200 Question
If one measures a large zone of inhibition in a
disk-diffusion test, one can assume that the
bacteria are
a. sensitive to the antibiotic.
b. resistant to the antibiotic.
c. unaffected by the antibiotic.
d. producing the antibiotic.
ANSWER
BACK TO GAME

35. © 2016 Pearson Education, Inc.
Topic 4: Resistance
$200 Answer
If one measures a large zone of inhibition in a
disk-diffusion test, one can assume that the
bacteria are
a. sensitive to the antibiotic.
b. resistant to the antibiotic.
c. unaffected by the antibiotic.
d. producing the antibiotic.
BACK TO GAME

36. © 2016 Pearson Education, Inc.
Topic 4: Resistance
$300 Question
Which of the following is NOT a method of
antibiotic misuse?
a. prescribing antibiotics for the common cold
b. finishing the full regimen
c. using outdated antibiotics
d. using antibiotics in animal feed
ANSWER
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37. © 2016 Pearson Education, Inc.
Topic 4: Resistance
$300 Answer
Which of the following is NOT a method of
antibiotic misuse?
a. prescribing antibiotics for the common cold
b. finishing the full regimen
c. using outdated antibiotics
d. using antibiotics in animal feed
BACK TO GAME

38. © 2016 Pearson Education, Inc.
Topic 4: Resistance
$400 Question
What was the FIRST penicillinase-resistant drug
to be developed?
a. vancomycin
b. penicillin G
c. methicillin
d. clavulanic acid
ANSWER
BACK TO GAME

39. © 2016 Pearson Education, Inc.
Topic 4: Resistance
$400 Answer
What was the FIRST penicillinase-resistant drug
to be developed?
a. vancomycin
b. penicillin G
c. methicillin
d. clavulanic acid
BACK TO GAME

40. © 2016 Pearson Education, Inc.
Topic 4: Resistance
$500 Question
Gram-negative bacteria are relatively more
resistant to antibiotics because
a. they are too small for the antibiotic to attack.
b. they all have capsules that resist antibiotics.
c. their cell wall restricts absorption of
molecules through porins.
d. they secrete antibiotic-destroying compounds.
ANSWER
BACK TO GAME

41. © 2016 Pearson Education, Inc.
Topic 4: Resistance
$500 Answer
Gram-negative bacteria are relatively more
resistant to antibiotics because
a. they are too small for the antibiotic to attack.
b. they all have capsules that resist antibiotics.
c. their cell wall restricts absorption of
molecules through porins.
d. they secrete antibiotic-destroying compounds.
BACK TO GAME

42. © 2016 Pearson Education, Inc.
Topic 5: Today and the Future
$100 Question
Assessing the risks and benefits when
administering drugs is termed
a. the therapeutic index.
b. the assessment index.
c. therapeutic management.
d. assessment management.
ANSWER
BACK TO GAME

43. © 2016 Pearson Education, Inc.
Topic 5: Today and the Future
$100 Answer
Assessing the risks and benefits when
administering drugs is termed
a. the therapeutic index.
b. the assessment index.
c. therapeutic management.
d. assessment management.
BACK TO GAME

44. © 2016 Pearson Education, Inc.
Topic 5: Today and the Future
$200 Question
Seventy percent of antibiotics produced in the
United States are
a. used for treating disease.
b. exported to other countries.
c. used in animal feed to promote growth.
d. available over the counter.
ANSWER
BACK TO GAME

45. © 2016 Pearson Education, Inc.
Topic 5: Today and the Future
$200 Answer
Seventy percent of antibiotics produced in the
United States are
a. used for treating disease.
b. exported to other countries.
c. used in animal feed to promote growth.
d. available over the counter.
BACK TO GAME

46. © 2016 Pearson Education, Inc.
Topic 5: Today and the Future
$300 Question
The chemotherapeutic effect of two drugs given
simultaneously that is greater than the effect of
either given alone is known as
a. symbiosis.
b. commensalism.
c. synergism.
d. antagonism.
ANSWER
BACK TO GAME

47. © 2016 Pearson Education, Inc.
Topic 5: Today and the Future
$300 Answer
The chemotherapeutic effect of two drugs given
simultaneously that is greater than the effect of
either given alone is known as
a. symbiosis.
b. commensalism.
c. synergism.
d. antagonism.
BACK TO GAME

48. © 2016 Pearson Education, Inc.
Topic 5: Today and the Future
$400 Question
Which of the following is NOT a way to prevent
the development of resistance?
a. using broad-spectrum antibiotics when
possible
b. always finishing the full regimen of antibiotics
c. never using leftover antibiotics to treat new
illness
d. avoiding unnecessary prescriptions ANSWER
BACK TO GAME

49. © 2016 Pearson Education, Inc.
Topic 5: Today and the Future
$400 Answer
Which of the following is NOT a way to prevent
the development of resistance?
a. using broad-spectrum antibiotics when
possible
b. always finishing the full regimen of antibiotics
c. never using leftover antibiotics to treat new
illness
d. avoiding unnecessary prescriptions
BACK TO GAME

50. © 2016 Pearson Education, Inc.
Topic 5: Today and the Future
$500 Question
Magainins and squalamine are examples of what
defense system produced by MOST forms of life?
a. complement system
b. antibodies
c. interferons
d. antimicrobial peptides
ANSWER
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51. © 2016 Pearson Education, Inc.
Topic 5: Today and the Future
$500 Answer
Magainins and squalamine are examples of what
defense system produced by MOST forms of life?
a. complement system
b. antibodies
c. interferons
d. antimicrobial peptides
BACK TO GAME

52. © 2016 Pearson Education, Inc.
FINAL ROUND Question
Russian scientists have experimented with what
agents as a means of therapy for killing
pathogenic bacteria?
a. helminths
b. bacteriophages
c. fungi
d. protozoa
ANSWER
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53. © 2016 Pearson Education, Inc.
FINAL ROUND Answer
Russian scientists have experimented with what
agents as a means of therapy for killing
pathogenic bacteria?
a. helminths
b. bacteriophages
c. fungi
d. protozoa
BACK TO GAME