Ch. 19 Game Show Jeopardy

1. Chapter 19: Antimicrobial Drugs
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History Antimicrobials
Mode of
Action
Resistance
Today and
the Future
FINAL ROUND

2. Topic 1: History
$100 Question
The birth of modern chemotherapy is credited
to the efforts of
a. Alexander Fleming.
b. Paul Ehrlich.
c. Robert Koch.
d. Louis Pasteur.
ANSWER
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3. Topic 1: History
$100 Answer
The birth of modern chemotherapy is credited
to the efforts of
a. Alexander Fleming.
b. Paul Ehrlich.
c. Robert Koch.
d. Louis Pasteur.
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4. Topic 1: History
$200 Question
In 1928, who observed that the growth of bacteria
was inhibited on a Petri plate contaminated by a
mold?
a. Alexander Fleming
b. Robert Koch
c. James Watson
d. Francis Crick
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ANSWER

5. Topic 1: History
$200 Answer
In 1928, who observed that the growth of bacteria
was inhibited on a Petri plate contaminated by a
mold?
a. Alexander Fleming
b. Robert Koch
c. James Watson
d. Francis Crick
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6. Topic 1: History
$300 Question
What was the first antibiotic discovered?
a. tetracycline
b. erythromycin
c. streptomycin
d. penicillin
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ANSWER

7. Topic 1: History
$300 Answer
What was the first antibiotic discovered?
a. tetracycline
b. erythromycin
c. streptomycin
d. penicillin
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8. Topic 1: History
$400 Question
In World War II, which of following made it clear
that antimicrobial agents could be effective against
systemic bacterial infections?
a. sulfa drugs
b. penicillin
c. tetracycline
d. erythromycin
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ANSWER

9. Topic 1: History
$400 Answer
BACK TO GAME
In World War II, which of following made it clear
that antimicrobial agents could be effective against
systemic bacterial infections?
a. sulfa drugs
b. penicillin
c. tetracycline
d. erythromycin

10. Topic 1: History
$500 Question
More than half of our antibiotics are produced by
species of
a. Mycobacterium.
b. Streptomyces.
c. Clostridium.
d. Bacillus.
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ANSWER

11. Topic 1: History
$500 Answer
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More than half of our antibiotics are produced by
species of
a. Mycobacterium.
b. Streptomyces.
c. Clostridium.
d. Bacillus.

12. Topic 2: Antimicrobials
$100 Question
Which of the following are the easiest to treat with
antimicrobial agents?
a. viruses
b. fungi
c. bacteria
d. protozoa
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ANSWER

13. Topic 2: Antimicrobials
$100 Answer
Which of the following are the easiest to treat with
antimicrobial agents?
a. viruses
b. fungi
c. bacteria
d. protozoa
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14. Topic 2: Antimicrobials
$200 Question
One disadvantage to using broad-spectrum
antibiotics is
a. superinfection.
b. selective toxicity.
c. toxicity.
d. inhibition.
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ANSWER

15. Topic 2: Antimicrobials
$200 Answer
One disadvantage to using broad-spectrum
antibiotics is
a. superinfection.
b. selective toxicity.
c. toxicity.
d. inhibition.
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16. Topic 2: Antimicrobials
$300 Question
Practically all antibiotic-producing microbes have
the ability to produce a(n)
a. exotoxin.
b. spore.
c. endotoxin.
d. capsule.
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ANSWER

17. Topic 2: Antimicrobials
$300 Answer
Practically all antibiotic-producing microbes have
the ability to produce a(n)
a. exotoxin.
b. spore.
c. endotoxin.
d. capsule.
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18. Topic 2: Antimicrobials
$400 Question
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ANSWER
If a microbial drug prevents microbes from
growing, its action is termed
a. bactericidal.
b. selectively toxic.
c. bacteriostatic.
d. toxic.

19. Topic 2: Antimicrobials
$400 Answer
BACK TO GAME
If a microbial drug prevents microbes from
growing, its action is termed
a. bactericidal.
b. selectively toxic.
c. bacteriostatic.
d. toxic.

20. Topic 2: Antimicrobials
$500 Question
Which of the following antimicrobials has the
broadest spectrum of activity?
a. streptomycin
b. isoniazid
c. penicillin G
d. tetracycline
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ANSWER

21. Topic 2: Antimicrobials
$500 Answer
Which of the following antimicrobials has the
broadest spectrum of activity?
a. streptomycin
b. isoniazid
c. penicillin G
d. tetracycline
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22. Topic 3: Mode of Action
$100 Question
How many major modes of action are utilized by
antimicrobial drugs?
a. four
b. five
c. three
d. six
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ANSWER

23. Topic 3: Mode of Action
$100 Answer
How many major modes of action are utilized by
antimicrobial drugs?
a. four
b. five
c. three
d. six
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24. Topic 3: Mode of Action
$200 Question
Eukaryotes have 80S ribosomes, and prokaryotes
have _____ ribosomes.
a. 90S
b. 60S
c. 80S
d. 70S
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ANSWER

25. Topic 3: Mode of Action
$200 Answer
Eukaryotes have 80S ribosomes, and prokaryotes
have _____ ribosomes.
a. 90S
b. 60S
c. 80S
d. 70S
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26. Topic 3: Mode of Action
$300 Question
Some antimicrobial agents demonstrate
competitive inhibition, as is represented by the
relationship of sulfanilamide and
a. peptidoglycan.
b. para-aminobenzoic acid.
c. teichoic acid.
d. muramic acid.
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ANSWER

27. Topic 3: Mode of Action
$300 Answer
Some antimicrobial agents demonstrate
competitive inhibition, as is represented by the
relationship of sulfanilamide and
a. peptidoglycan.
b. para-aminobenzoic acid.
c. teichoic acid.
d. muramic acid.
BACK TO GAME

28. Topic 3: Mode of Action
$400 Question
The mode of action of chloramphenicol is to
a. inhibit cell wall synthesis.
b. inhibit nucleic acid synthesis.
c. injure the plasma membrane.
d. inhibit protein synthesis.
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ANSWER

29. Topic 3: Mode of Action
$400 Answer
BACK TO GAME
The mode of action of chloramphenicol is to
a. inhibit cell wall synthesis.
b. inhibit nucleic acid synthesis.
c. injure the plasma membrane.
d. inhibit protein synthesis.

30. Topic 3: Mode of Action
$500 Question
The antifungal drug amphotericin combines with
sterols to disrupt the activity of the fungus. Its
mode of action is to
a. inhibit the synthesis of essential metabolites.
b. injure the plasma membrane.
c. inhibit nucleic acid synthesis.
d. inhibit cell wall synthesis.
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ANSWER

31. Topic 3: Mode of Action
$500 Answer
The antifungal drug amphotericin combines with
sterols to disrupt the activity of the fungus. Its
mode of action is to
a. inhibit the synthesis of essential metabolites.
b. injure the plasma membrane.
c. inhibit nucleic acid synthesis.
d. inhibit cell wall synthesis.
BACK TO GAME

32. Topic 4: Resistance
$100 Question
Bacteria that are resistant to large numbers of
antibiotics are popularly termed
a. superbugs.
b. superinfections.
c. MRSA.
d. synergism.
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ANSWER

33. Topic 4: Resistance
$100 Answer
Bacteria that are resistant to large numbers of
antibiotics are popularly termed
a. superbugs.
b. superinfections.
c. MRSA.
d. synergism.
BACK TO GAME

34. Topic 4: Resistance
$200 Question
If one measures a large zone of inhibition in a
disk-diffusion test, one can assume that the
bacteria are
a. sensitive to the antibiotic.
b. resistant to the antibiotic.
c. unaffected by the antibiotic.
d. bactericidal.
ANSWER
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35. Topic 4: Resistance
$200 Answer
BACK TO GAME
If one measures a large zone of inhibition in a
disk-diffusion test, one can assume that the
bacteria are
a. sensitive to the antibiotic.
b. resistant to the antibiotic.
c. unaffected by the antibiotic.
d. bactericidal.

36. Topic 4: Resistance
$300 Question
Which of the following is NOT a method of
antibiotic abuse?
a. prescribing antibiotics for the common cold
b. adhering to the dose regimen
c. using outdated antibiotics
d. using antibiotics in animal feed
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ANSWER

37. Topic 4: Resistance
$300 Answer
Which of the following is NOT a method of
antibiotic abuse?
a. prescribing antibiotics for the common cold
b. adhering to the dose regimen
c. using outdated antibiotics
d. using antibiotics in animal feed
BACK TO GAME

38. Topic 4: Resistance
$400 Question
What was the first penicillinase-resistant drug to
be developed?
a. vancomycin
b. penicillin G
c. methicillin
d. clavulanic acid
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ANSWER

39. Topic 4: Resistance
$400 Answer
BACK TO GAME
What was the first penicillinase-resistant drug to
be developed?
a. vancomycin
b. penicillin G
c. methicillin
d. clavulanic acid

40. Topic 4: Resistance
$500 Question
The main mechanism for resistance of MRSA to
methicillin is
a. a new inactivating enzyme.
b. rapid ejection of the antibiotic.
c. modifying the penicillin-binding protein (PBP)
on the cell’s membrane.
d. restriction of the absorption through porins.
BACK TO GAME
ANSWER

41. Topic 4: Resistance
$500 Answer
BACK TO GAME
The main mechanism for resistance of MRSA to
methicillin is
a. a new inactivating enzyme.
b. rapid ejection of the antibiotic.
c. modifying the penicillin-binding protein
(PBP) on the cell’s membrane.
d. restriction of the absorption through porins.

42. Topic 5: Today and the Future
$100 Question
Assessing the risks and benefits when
administering drugs is termed
a. therapeutic index.
b. assessment index.
c. therapeutic management.
d. assessment management.
BACK TO GAME
ANSWER

43. Topic 5: Today and the Future
$100 Answer
Assessing the risks and benefits when
administering drugs is termed
a. therapeutic index.
b. assessment index.
c. therapeutic management.
d. assessment management.
BACK TO GAME

44. Topic 5: Today and the Future
$200 Question
The largest arsenal of drugs is against
a. viruses.
b. protozoa.
c. bacteria.
d. helminths.
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ANSWER

45. Topic 5: Today and the Future
$200 Answer
The largest arsenal of drugs is against
a. viruses.
b. protozoa.
c. bacteria.
d. helminths.
BACK TO GAME

46. Topic 5: Today and the Future
$300 Question
The treatment of bacterial endocarditis is much
more effective when both penicillin and
streptomycin are used together than when taken
alone. This is an example of
a. symbiosis.
b. commensalism.
c. synergism.
d. antagonism.
BACK TO GAME
ANSWER

47. Topic 5: Today and the Future
$300 Answer
BACK TO GAME
The treatment of bacterial endocarditis is much
more effective when both penicillin and
streptomycin are used together than when taken
alone. This is an example of
a. symbiosis.
b. commensalism.
c. synergism.
d. antagonism.

48. Topic 5: Today and the Future
$400 Question
All of the following represent new and future
targets for antimicrobial activity EXCEPT
a. use of protein synthesis inhibition.
b. use of antimicrobial peptides.
c. targeting virulence factors.
d. use of phage therapy.
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ANSWER

49. Topic 5: Today and the Future
$400 Answer
All of the following represent new and future
targets for antimicrobial activity EXCEPT
a. use of protein synthesis inhibition.
b. use of antimicrobial peptides.
c. targeting virulence factors.
d. use of phage therapy.
BACK TO GAME

50. Topic 5: Today and the Future
$500 Question
Which antimicrobial has existed for an indefinite
time without significant development of
resistance?
a. methicillin
b. β-lactam
c. vancomycin
d. magainins
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ANSWER

51. Topic 5: Today and the Future
$500 Answer
Which antimicrobial has existed for an indefinite
time without significant development of
resistance?
a. methicillin
b. β-lactam
c. vancomycin
d. magainins
BACK TO GAME

52. FINAL ROUND Question
Russian scientists are currently experimenting
with phage therapy as a method to treat
infections of
a. viruses.
b. bacteria.
c. fungi.
d. protozoa.
BACK TO GAME
ANSWER

53. FINAL ROUND Answer
Russian scientists are currently experimenting
with phage therapy as a method to treat
infections of
a. viruses.
b. bacteria.
c. fungi.
d. protozoa.
BACK TO GAME