Design and Development of a Provenance Capture Platform for Data Science
Luminesce製造流程
1. Jeunesse Global LLC
LUMINESCE™賦活青春精華露的製造過程
Jeunesse Global’s manufacturer utilizes a bench top bio-reactor (50L) for
the production of the Adipose Derived Adult Stem Cell Conditioned Media.
The manufacturing batch sizes are 1000L per lot. Briefly, the Conditioned
Media is optimized to the bench top bio-reactor 50L reaction vessel and
then it’s transferred to the 1000L reaction vessel. It is then flash frozen
2. at -80 degrees Celsius, and then further bio-processed, (including pH
adjustments) filtered and packaged for shipment. The Conditioned Media
is manufactured within 2 weeks and is eventually released by Quality
Control within a 7 day period. It is filtered through a 0.1u pore size and
filled into 20L containers which are then labeled and packaged for
shipment at room temperature. The Conditioned Media is then stored at
-20 degrees Celsius until ready for mixing into the final LUMINESCE™
cellular rejuvenation serum formula.
美商婕斯環球有限公司採用全球最先進的平台式生物反應裝置來製造成人脂肪幹
細胞的條件培養基，每批產量可達1,000公升。簡單來說，先將篩選過濾後的成人
脂肪幹細胞置放於生物反應裝置的50公升反應容器內進行培養，此反應裝置可讓
幹細胞發揮最大效用並生成含生長因子和豐富蛋白質的條件培養基，然後取出幹
細胞後，再存放於另一個1,000公升的反應裝置儲存槽內，並以-80℃急速冷凍後，
再進行進階生化作用(包含pH值調整)，過濾及裝填程序。每批條件培養基的製程
除了須耗時２週外，還需再經過7天品質檢驗的最後一道手續，包括通過0.1u的過
濾篩檢後，再填裝於20公升的分類容器並保存於-20℃的冷藏庫，最後再添加其他
的有效成份後，即完成LUMINESCE™賦活青春精華露的製造過程。
3. We also utilize the 100L mixing tank once the Conditioned Media is
processed from the bioreactors prior to being processed in the 1000L
reaction vessel.
我們通常在平台式生物反應裝置製成條件培養基後，但在導入1,000公升的反應裝
置容器前，會先利用100公升的混和槽進行初步的過濾程序。
4. This is the 1000L tank for further processing of the Conditioned Media,
in which the -80 degrees Celsius Conditioned Media is mixed and pH
adjusted prior to final 0.1u filtration into 20L containers.
此為提供條件培養基進行進階生化作用的1,000公升反應裝置儲存槽，在進行0.1u
過濾篩檢並填裝至20公升的容器前，已經過-80℃急速冷凍的條件培養基會先於此
槽中進行調和並調整到正確的pH值。
Human Adipose Derived Stem Cells
成人脂肪幹細胞(一)
