1. STUDY ON 3D-BIOPRINTING
Presented by:
V Harish Reddy
(14D91A0390)
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
2. CONTENTS
Abstract
3d printing
The history of bioprinting
Important materials
Components for 3d-bioprinting
Taking readings
Designing
Preparing bioink
Printing process
Applications
Advantages
Disadvantages
Conclusion
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
3. ABSTRACT
• Three-dimensional bio printing is the utilization of 3D
printing and 3D printing–like techniques.
• it consists of combination of cells, growth factors, and
biomaterials to fabricate biomedical parts that maximally
imitate natural tissue characteristics.
• The process of bio printing is done on a “3D-bio printer”,
these printer uses two ink type substances which are
living cells and a gel like fluid for the bonding of cells.
• This technology has a greater scope in future. A doctor
in a clinic can directly print your organs in front of you
and you can have them replaced with one which are
failed or lo
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
4. CHAPTER: 1
3D PRINTING
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
Advancements in 3D-printing till date
5. CHAPTER:2
HISTORY OF 3-D BIOPRINTING
• 1984_ Charles Hull_ invented stereolithography.
• 1996_ Dr. Gabor forgacs_ discovered cells can combine to
form tissues.
• 2003_ thomas boland_ modified ink-jet printer.
• 2004_ dr. Gabor forgacs_ discovered tissues can combine
to form organs.
• 2009-2010_ organovo_ invented novo MMX Bioprinter
using Dr.gabor forgacs technology.
• 2013_ 0rganovo_ discovered multiple drug discovery
platforms and 3D printed disease models.
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
6. CHAPTER: 3
3.1 Human cells
3.2 Stem cells
IMPORTANT MATERIALS
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
7. 3.3 Hydrogel
•This is a gel which is
similar to water.
•But it has abundance of
proteins, minerals,
vitamins and nutrients.
• this hydrogel helps the
cells to sustain during
the period of mutation
after they get printed.
•And also it helps to
maintain cavities in the
organs.
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
8. 3.4 COMPONENTS FOR 3D-BIOPRINTING
3.4.1 Cells
3.4.2Hydrogel
3.4.3 Novogen mmx bio printer
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
9. 3.5 TAKING READINGS
Exact measurements of the organ are taken using
MRI scanner.
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
10. 3.6 DESIGNING
The data is used to make a design of the organ
which is to be printed.
Then the design is then converted in to “stl” file for
building the design layer by layer.
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
11. 3.7 PREPARING BIOINK
3.7.1 Biopsy
3.7.2 Stem cells
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
12. CHAPTER: 4
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
13. CHAPTER: 5
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
16. CHAPTER: 6
6.1 USE OF 3D-PRINTING IN MEDICAL FIELD
•Used to study the disease progression.
•Used to test drugs.
•Used to train the medical student without using any
dead body or living human body.
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
17. 6.2 ADVANTAGES
Replacing of diseased organs.
Eliminate organ donation.
Best way to relieve from cancer
Decrease death rate caused due to organ failure or
cancers.
Can test drugs on the printed organs to learn the
behaviour.
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
18. 6.3 DISADVANTAGES
The replaced cells may not fit in the human body.
Large scale construction increases complexity.
Cannot not produce large scale due to change
genes.
Increase in population due to decrease in death
rate.
Bioprinters are costly.
Possibly more expensive than organ transplant.
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
19. CONCLUSION
So according to my study i gone through so many
researeches and found that only three organs are
not possible to print those are:
1. Brain
2. Eyes
3. Sexual organs
Department of Mechanical Engineering
Aurora’s Scientific, Technological and Research Academy
Three-dimensional bio printing is the utilization of 3D printing and 3D printing–like techniques.
it consists of combination of cells, growth factors, and biomaterials to fabricate biomedical parts that maximally imitate natural tissue characteristics.
The process of bio printing is done on a “3D-bio printer”, these printer uses two ink type substances which are living cells and a gel like fluid for the bonding of cells.
This technology has a greater scope in future. A doctor in a clinic can directly print your organs in front of you and you can have them replaced with one which are failed or lost.
