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COMPUTATIONAL BIOLOGY

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Krupali Gandhi
Krupali Gandhi

IT IS ABOUT THE EMERGING BRANCH OF BIOTECHNOLOGY. USE OF COMPUTERS AND CODECS TO DECODE BIOLOGICAL MYSTERIES.

Science
1 of 19
A Galaxy Of Codes In You........
TO THE ASCII OF HUMANS -KRUPALI GANDHI
• Open source software- - reproducibility - faster development -increased quality - long term availability • CADD- computer aided drug design • CAD/CAM- computer aided design and computer aided manufacturing • BLAST- basic local alignment search tool
BIOINFOR MATICS COMPUTATIONAL BIOMODELLING COMPUTATIONAL PHARMACOLOGY CANCER COMPUTATIONAL BIOLOGY COMPUTATIONAL GENOMICS
proteins The human genome project data Pharmacological application
Darwin’s theory of evolution, the genetic bases of humans(homo sapiens) found from apes..
1953- structure of DNA discovered 1995- first bacterial genome 2001- first human genome drafting starts 2004- human genome completed 2004- computer platform used 2010- bench-top next gen sequencers used
The designer babies !!! • Babies without Genetic disorders!!
To eradicate diseases from babies is one story, But to build a baby.....???
•Discovery •Predicting •Modeling •Stimulating potential therapeutic effects •Pharmacokinetics
 Use of computer stimulations of biological systems, including cellular subsystems (network metabolites, enzymes, metabolism, signal transduction pathways, gene regulatory networks) to analyze and visualize complex connections of these cellular processes...  Tasks- cellular model - multi-cellular organism stimulation - protein folding - brain model - immune systems - virtual liver - modeling of infectious disease
Computer assisted surgical planning on 3-D liver HEPATOSYS- programme supporting projects looking at cellular networks of the liver cell.
CAD/CAM techniques -crowns, crown lays -Veneers, -Inlays, onlays -Fixed bridges, -Dental implant restorations, -Dentures -Orthodontic appliances
 To the era of disease free kids....  No human and animal testing of drugs  Cancer-free society  Looking inside humans- human genomics drafts....  For us- computer dentists!!!
Thank you

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COMPUTATIONAL BIOLOGY

Editor's Notes

  1. t involves the use of computer simulations of biological systems, including cellular subsystems (such as the networks of metabolites and enzymes which comprise metabolism, signal transduction pathways and gene regulatory networks), to both analyze and visualize the complex connections of these cellular processes.
  2. design and creation of dental restorations including crowns, crown lays, veneers, inlays and onlays, fixedbridges, dental implant restorations, dentures (removable or fixed), and orthodontic appliances