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Association cortices
Motor Sensory Association
Somato Sensory Pathway
Sensory Cortex Receptive Field
Two Point Discrimination
Columnar organization of somatosensory cortex
Sensory Cortex
                            Area 5 integrates tactile
                          information from mechanoreceptors
                          in the skin with proprioceptive
                          inputs from the underlying muscles
                          and joints.
                            This region also integrates
                          information from the two hands.
                            Area 7 receives visual as well as
                          tactile and proprioceptive inputs,
                          allowing integration of stereognostic
                          and visual information.
                            The posterior parietal cortex
                          projects to the motor areas of the
                somatic   frontal lobe and plays an important
Proprioceptiv
                          role in sensory initiation and
e
                          guidance of movement.
Association Cortex Information Flow
Pattern of Vibration of the Basilar Membrane
The Auditory Cortex
Discrimination of Sound “Patterns” by the Auditory Cortex
Pathways to the somatosensory, visual, and auditory association areas
Visual Pathway
AIT = anterior inferior temporal area; CIT = central inferior temporal area; LIP = lateral
intraparietal area; Magno = magnocellular layers of the lateral geniculate nucleus; MST =
medial superior temporal area; MT = middle temporal area; Parvo = parvocellular layers of the
lateral geniculate nucleus; PIT = posterior inferior temporal area; VIP = ventral intraparietal
area.) (Based on Merigan and Maunsell 1993.)
Pathways to the somatosensory, visual, and auditory association areas
Unimodal sensory inputs converge on multimodal association areas
Interaction Among Association Areas Leads to Comprehension, Cognition,
and Consciousness
Emotion Localization
Parietal Lobe
Left Hemisphere

         Cortical Sensory Loss
         Disorder of language
               Fluent aphasia, alexia
         Gerstman’s syndrome (Angular gyrus)
               acalculia,
               finger agnosia,
               left/right disorientation,
               agraphia
         Tactile agnosia (bimanual asteriognosis)
         Bilateral Ideomotor & ideational apraxia
Right hemisphere

       Cortical Sensory Loss

       Topographic disorientation

       Topographic memory loss

       Anosognosia /dressing apraxia

       Constructional apraxia

       Hemi-inattention

       Apraxia of eye opening

       Confusion
“Attention Neurons” in the Monkey Parietal Cortex
Attention activity of Right Parietal Cortex in Normal
Contralateral Neglenct Syndrome
Temporal Lobe
Either Temporal dysfunction

 Auditory
    –   Threshold of brief auditory stimuli elevated
    –   Spoken words less clear
    –   Distorted words are less clear
    –   Difficulty in equalizing sound presented to both ear
    –   Rapidly presented words and number in both ear difficult to
        perceiving
 Hallucination
    – Auditory,
    – visual,
    – olfactory and
    – gustatory
 Emotional and behavioral changes
 Delirium
Left temporal dysfunction


Auditory deficits (right ear)
   –   Intracranial localization of sound is impaired.
   –   Increased threshold for perception of short bursts of sound.
   –   Increased threshold for some frequencies.
   –   Failure to perceive brief simultaneous auditory stimulation.
Visual deficit (both eyes)
   –   Upper right quadrantanopsia.
Other complex sensory deficits
   –   Right hand tactile performance difficulty.
   –   Right hand finger agnosia.
Left temporal dysfunction

Language deficits
   –   Decoding of speech sounds (phonemes) is impaired.
   –   Problems with verbal repetition.
   –   Problems with auditory comprehension of speech.
   –   Receptive aphasia (deficits in all language qualities).
   –   Impairment of dichotic listening to verbal material.
   –   Intellectual impairment on verbally mediated intellectual
       processes.
Memory impaired for verbal material.
Emotional disturbances
   –   Perceptual distortions, alterations of mood, obsessional
       thinking, psychosis, temper outbursts, hypo and hypersexuality
Right Temporal dysfunction
Right temporal lesion effects tend to be      3.   Auditory analysis (nonverbal)
     notable statistically but of less             –   Impairment of short-term auditory
     clinical significance.                            memory.
1.Visual analysis (nonverbal primarily)            –   Perception of short sounds
    –    Impairment of simple and complex              impaired.
         visual analysis, but some negative        –   Impaired recognition of familiar
         findings.                                     sounds.
    –    Impairment of short-term
                                                   –   Impaired tonal discriminations,
         nonverbal memory.
                                                       timbre discriminations, and
    –    Impaired perception of
                                                       amplitude discriminations.
         tachistoscopically-presented
         letters.                                  –   Amusia.
    –    Prosopoagnosia (especially with           –   Impairment of contralateral ear
         anterior lesions).                            input in dichotic listening.
    –    Impaired recognition of objects
         seen from unusual angles
Right Temporal dysfunction

4.   Constructional tasks                 6.   Psychometric findings
     –   Visual construction impairment        –   Temporary decline in
         proportional to tissue loss.              Performance IQ following
     –   Impairment in maze learning               lobectomy.
         (visual and proprioceptive            –   Impairment on WAIS Picture
         feedback).                                Arrangement.
     –   Enlarged left-hand margin in          –   Impairment on Binet Memory
         dictation.                                for Designs
5.   Psychiatric personality                   –   Possible impairment of WAIS
     phenomena with right temporal                 Block Design?.
     epilepsy                             7.   Persistence in maintaining a
     –   Personality changes.                  hypothesis even after being
     –   Psychiatric symptoms.                 informed it was not correct.
     –   Deja vue.
     –   Metamorphopasias.
Bitemporal dysfunction


 Human bitemporal lesion
     – Kluver bucy like + aphasia, amnesia and bulimia
 Bilateral inferior and medial temporal lesion
     – Sham rage like
     – React to every stimuli with extreme belligerence, screaming, cursing ,
       biting and spiting
 Bilateral post cortical lesion
     –   Cortical deafness – unaware of deafness
 Korsakoff amnesic defect
Selective activation of face cells in the inferior temporal cortex of a
rhesus monkey
Prosopognosia
Occipital Lobe
Unilateral occipital lesion

      Contralateral (congruent) homonymous hemianopia, may be
      central (spitting the macula or peripheral
      Homonymous hemiachromatopsia
      Elementry unformed hallucination – irritative lesions
Left occipital lesion

          Right homonymous hemianopia

          Alexia and color naming defect with deep white matter or

          splenium of corpus callosum involved

          Visual object agnosia
Right occipital lesion

    Left homonymous hemianopia

    Visual illusion, (metamorphopsias), and hallucinations

    Loss of topographic memory and visual orientation
Bilateral occipital lesions

                Cortical blindness
                Anton syndrome
                Loss of perception of color
                Prosopognosia and simultagnosia
                Balint syndrome
Balint Syndrome (Bilateral parietooccipital region)

   An inability to look voluntarily into the peripheral field, with normal
   eye movements (psychic paralysis of fixation gaze)
   A failure to precisely grasp or touch an object under visual
   guidance, hand and eyes in- coordinated (optic ataxia)
   Visual inattention affecting mainly the periphery of the visual field,
   attention to other sensory stimuli being intact
   Failure to properly direct occulomotor function in the exploration of
   space (amorphosynthesis)
Thank You

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07b posterior association cortex

  • 6. Columnar organization of somatosensory cortex
  • 7. Sensory Cortex Area 5 integrates tactile information from mechanoreceptors in the skin with proprioceptive inputs from the underlying muscles and joints. This region also integrates information from the two hands. Area 7 receives visual as well as tactile and proprioceptive inputs, allowing integration of stereognostic and visual information. The posterior parietal cortex projects to the motor areas of the somatic frontal lobe and plays an important Proprioceptiv role in sensory initiation and e guidance of movement.
  • 9.
  • 10. Pattern of Vibration of the Basilar Membrane
  • 12. Discrimination of Sound “Patterns” by the Auditory Cortex
  • 13. Pathways to the somatosensory, visual, and auditory association areas
  • 15. AIT = anterior inferior temporal area; CIT = central inferior temporal area; LIP = lateral intraparietal area; Magno = magnocellular layers of the lateral geniculate nucleus; MST = medial superior temporal area; MT = middle temporal area; Parvo = parvocellular layers of the lateral geniculate nucleus; PIT = posterior inferior temporal area; VIP = ventral intraparietal area.) (Based on Merigan and Maunsell 1993.)
  • 16. Pathways to the somatosensory, visual, and auditory association areas
  • 17. Unimodal sensory inputs converge on multimodal association areas
  • 18. Interaction Among Association Areas Leads to Comprehension, Cognition, and Consciousness
  • 21. Left Hemisphere Cortical Sensory Loss Disorder of language Fluent aphasia, alexia Gerstman’s syndrome (Angular gyrus) acalculia, finger agnosia, left/right disorientation, agraphia Tactile agnosia (bimanual asteriognosis) Bilateral Ideomotor & ideational apraxia
  • 22. Right hemisphere Cortical Sensory Loss Topographic disorientation Topographic memory loss Anosognosia /dressing apraxia Constructional apraxia Hemi-inattention Apraxia of eye opening Confusion
  • 23. “Attention Neurons” in the Monkey Parietal Cortex
  • 24. Attention activity of Right Parietal Cortex in Normal
  • 27. Either Temporal dysfunction Auditory – Threshold of brief auditory stimuli elevated – Spoken words less clear – Distorted words are less clear – Difficulty in equalizing sound presented to both ear – Rapidly presented words and number in both ear difficult to perceiving Hallucination – Auditory, – visual, – olfactory and – gustatory Emotional and behavioral changes Delirium
  • 28. Left temporal dysfunction Auditory deficits (right ear) – Intracranial localization of sound is impaired. – Increased threshold for perception of short bursts of sound. – Increased threshold for some frequencies. – Failure to perceive brief simultaneous auditory stimulation. Visual deficit (both eyes) – Upper right quadrantanopsia. Other complex sensory deficits – Right hand tactile performance difficulty. – Right hand finger agnosia.
  • 29. Left temporal dysfunction Language deficits – Decoding of speech sounds (phonemes) is impaired. – Problems with verbal repetition. – Problems with auditory comprehension of speech. – Receptive aphasia (deficits in all language qualities). – Impairment of dichotic listening to verbal material. – Intellectual impairment on verbally mediated intellectual processes. Memory impaired for verbal material. Emotional disturbances – Perceptual distortions, alterations of mood, obsessional thinking, psychosis, temper outbursts, hypo and hypersexuality
  • 30. Right Temporal dysfunction Right temporal lesion effects tend to be 3. Auditory analysis (nonverbal) notable statistically but of less – Impairment of short-term auditory clinical significance. memory. 1.Visual analysis (nonverbal primarily) – Perception of short sounds – Impairment of simple and complex impaired. visual analysis, but some negative – Impaired recognition of familiar findings. sounds. – Impairment of short-term – Impaired tonal discriminations, nonverbal memory. timbre discriminations, and – Impaired perception of amplitude discriminations. tachistoscopically-presented letters. – Amusia. – Prosopoagnosia (especially with – Impairment of contralateral ear anterior lesions). input in dichotic listening. – Impaired recognition of objects seen from unusual angles
  • 31. Right Temporal dysfunction 4. Constructional tasks 6. Psychometric findings – Visual construction impairment – Temporary decline in proportional to tissue loss. Performance IQ following – Impairment in maze learning lobectomy. (visual and proprioceptive – Impairment on WAIS Picture feedback). Arrangement. – Enlarged left-hand margin in – Impairment on Binet Memory dictation. for Designs 5. Psychiatric personality – Possible impairment of WAIS phenomena with right temporal Block Design?. epilepsy 7. Persistence in maintaining a – Personality changes. hypothesis even after being – Psychiatric symptoms. informed it was not correct. – Deja vue. – Metamorphopasias.
  • 32. Bitemporal dysfunction Human bitemporal lesion – Kluver bucy like + aphasia, amnesia and bulimia Bilateral inferior and medial temporal lesion – Sham rage like – React to every stimuli with extreme belligerence, screaming, cursing , biting and spiting Bilateral post cortical lesion – Cortical deafness – unaware of deafness Korsakoff amnesic defect
  • 33. Selective activation of face cells in the inferior temporal cortex of a rhesus monkey
  • 36. Unilateral occipital lesion Contralateral (congruent) homonymous hemianopia, may be central (spitting the macula or peripheral Homonymous hemiachromatopsia Elementry unformed hallucination – irritative lesions
  • 37. Left occipital lesion Right homonymous hemianopia Alexia and color naming defect with deep white matter or splenium of corpus callosum involved Visual object agnosia
  • 38. Right occipital lesion Left homonymous hemianopia Visual illusion, (metamorphopsias), and hallucinations Loss of topographic memory and visual orientation
  • 39. Bilateral occipital lesions Cortical blindness Anton syndrome Loss of perception of color Prosopognosia and simultagnosia Balint syndrome
  • 40. Balint Syndrome (Bilateral parietooccipital region) An inability to look voluntarily into the peripheral field, with normal eye movements (psychic paralysis of fixation gaze) A failure to precisely grasp or touch an object under visual guidance, hand and eyes in- coordinated (optic ataxia) Visual inattention affecting mainly the periphery of the visual field, attention to other sensory stimuli being intact Failure to properly direct occulomotor function in the exploration of space (amorphosynthesis)