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Spermatogenesis
Abdullahi Ali Mohamed
• In testis, the immature malegerm cell (spermatogonia ) produce
sperms by spermatogenesis
• The spermatogonia ( sing. Spermatogonium ) presenton the inside
of seminiferous tubules multiply by mitotic division and increase in
numbers
• Each spermatogonium isdiploid and contains 46 chromosomes
• Someof thespermatogonia called primaryspermatocytes
periodicallyundergo meiosis
• A primary spermatocyte completes the first meiotic division
(reduction division) leading to formation of twoequal, haploid cells
called secondaryspermatocyte, which haveonly 23 chromosomes
• The secondary spermatocyte undergo the second meioticdivision to
produce fourequal, haploid spermatids
• The spermatidsare transferred into spermatozoa (sperms) by the
process called spermatogenesis
• After spermatogenesis, sperm heads become embedded in the
sertoli cells, and finally released from the seminiferous tubules by
the process called spermiation
• Spermatogenesis starts at the age of puberty due to
significant increase in the secretion of gonadotropin
releasing hormone (GnRH )
• The increased level of GnRH then acts at the anterior
pituitary gland and stimulates secretion of two
gonadotropin – luteinizing hormone (LH) and follicle
stimulating hormone (FSH)
• LH acts at the Leydig cells and stimulates synthesis of
androgens
• Androgens stimulate the process of spermatogenesis
• FSH acts on the sertoli cells and stimulates secretion of
some factors which help in the process of spermatogenesis
Structure of a sperm
• It isa microscopic structurecomposed of a head, neck, a middle
pieceand a tail
• A plasma membraneenvelops thewhole body of the sperm
• The sperm head contains an elongated haploid nucleus, theanterior
portion of which iscovered by acap-like structure, acrosome
• Theacrosome is filled with enzymes that help fertilizationof the
ovum
• The middle piece possesses numerous mitochondria, which produce
energy for the movementof tail that facilitatesperm motility
Spermatogenesis-Abdullahi Ali.pptx
Spermatogenesis-Abdullahi Ali.pptx

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Spermatogenesis-Abdullahi Ali.pptx

  • 2. • In testis, the immature malegerm cell (spermatogonia ) produce sperms by spermatogenesis • The spermatogonia ( sing. Spermatogonium ) presenton the inside of seminiferous tubules multiply by mitotic division and increase in numbers • Each spermatogonium isdiploid and contains 46 chromosomes • Someof thespermatogonia called primaryspermatocytes periodicallyundergo meiosis
  • 3.
  • 4. • A primary spermatocyte completes the first meiotic division (reduction division) leading to formation of twoequal, haploid cells called secondaryspermatocyte, which haveonly 23 chromosomes • The secondary spermatocyte undergo the second meioticdivision to produce fourequal, haploid spermatids
  • 5.
  • 6. • The spermatidsare transferred into spermatozoa (sperms) by the process called spermatogenesis • After spermatogenesis, sperm heads become embedded in the sertoli cells, and finally released from the seminiferous tubules by the process called spermiation
  • 7.
  • 8. • Spermatogenesis starts at the age of puberty due to significant increase in the secretion of gonadotropin releasing hormone (GnRH ) • The increased level of GnRH then acts at the anterior pituitary gland and stimulates secretion of two gonadotropin – luteinizing hormone (LH) and follicle stimulating hormone (FSH) • LH acts at the Leydig cells and stimulates synthesis of androgens
  • 9. • Androgens stimulate the process of spermatogenesis • FSH acts on the sertoli cells and stimulates secretion of some factors which help in the process of spermatogenesis
  • 10.
  • 11. Structure of a sperm • It isa microscopic structurecomposed of a head, neck, a middle pieceand a tail • A plasma membraneenvelops thewhole body of the sperm • The sperm head contains an elongated haploid nucleus, theanterior portion of which iscovered by acap-like structure, acrosome • Theacrosome is filled with enzymes that help fertilizationof the ovum • The middle piece possesses numerous mitochondria, which produce energy for the movementof tail that facilitatesperm motility