digestive disorders of the GI tract Solution The two common digestive disorders of the GI tract are, 1). Peptic ulcer disease (PUD) is a lesion of the mucosal layer n the stomach or duodenum that may be caused by pathogenic bacteria or pepsin and other gastric acids. The most common causes of peptic ulcers include the infection caused by the bacterium Helicobacter pylori or H. Pylori, medications that disturb the gastric mucosa, psychological pressures and irregular food habits that result in improper acid secretions that damages gastric mucosa. 2). Gastro esophageal reflux disorder (GERD) is a physiological abnormality in which the acidic contents of stomach reflex into esophagus. The causes of GERD include weakened lower esophageal sphincter, impaired acid clearance in the stomach due to unhealthy food habits and pregnancy, infection with H.pylori and stress. Heart burn and acid indigestion are the common symptoms of GERD..