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Personal Neuro Devices:
      Medical applications of
11/2/2012  mobile EEG           1
Electroencephalography (EEG)


             Reads brain activity


             Neurofeedback
              therapy


             Can track aspects of
              thought, emotion



11/2/2012
                                       2
Mobile EEG

             Not bound to lab


             Links to smartphone


             Makes EEG monitoring
              available anywhere


             Currently mostly for games

11/2/2012
                                           3
PND: mobile EEG software

                      Mobile EEG beyond games

                      Treatment, diagnostics, self-
                       monitoring

                      Team
                         neuroscientists
                         software engineers
                         biomedical engineers
                         business development
                          experts


11/2/2012
                                                 4
PND technologies: BackupBrain


             Stores EEG info online


             Accessible anywhere


             Deeper analysis




11/2/2012
                                        5
PND technologies: Amygdala

             Backend for non-game
              mobile EEG software


             Streamlines mobile EEG
              development


             Algorithms, built-in GUIs,
              links to BackupBrain, etc.


11/2/2012
                                           6
Proof-of-concept: Transcend




 Neurofeedback-based mobile meditation app


 Comprehensive meditation tracking & analysis


 Reads relaxation, concentration, meditation
    uses in-house algorithms
Introspect



 EEG self-monitoring


 Records mental
  states via EEG
  waveform analysis
Introspect
 Detects: (e.g.)
    Mood
    Anxiety
    Stress
    Acute cognitive
     functioning
    Sleep quality             Example waveforms
                             linked to mental states
    Concentration
    Pain „unpleasantness‟
Introspect
             Detects problem areas

             Built-in neurofeedback exercises to
              improve specific areas




                      PND neurofeedback game:
11/2/2012                psych showdown             10
Neurofeedback

             Training to directly
              alter EEG output

             Mindfulness-based
                Meditation

             Effective treatment
                  ADHD
                  depression
                  Anxiety
                  etc.


11/2/2012
                                           11
PND: Pharmaceutical uses
 Based on adaptations of Introspect


 Introspect malleable for
    Research
    Diagnostics
    Treatment
    Etc.
PND: Pharmaceutical uses
1) New drug testing

 mobile real-time drug efficacy monitoring

 E.g. observe mood in brain over time
PND: Pharmaceutical uses

            2) Aid patient-specific
            drug selection

             EEG patterns linked to
              disorder etiologies

             Help hospital funding




11/2/2012
                                          14
PND: Pharmaceutical uses

            3) Monitor patient progress

             Ensure continued symptom
              control

             Change treatments as
              needed




                  Example mood and anxiety chart
11/2/2012
                                                   15
PND: Pharmaceutical uses

            4) Augment treatments

             Raise overall efficacy

             Neurofeedback




11/2/2012
                                          16
PND: Pharmaceutical uses

            5) New class of as-
            needed meds

             Alarm for impending
              “attack”

             Preventative drug
              used upon alarm




11/2/2012
                                          17
PND: Pharmaceutical uses

6) Preventative medicine

 Catch “slipping” mental
  health before disorder
  develops
PND: Pharmaceutical uses


            7) Diagnostics

             Link day-to-day mental
              states to disorders

             Reduce reliance on
              self-report




11/2/2012
                                          19
Thank you!

Any questions?




                 20
References
•   MacDonald, P. E., Rorsman, P. (2006). Oscillations, intercellular coupling, and insulin secretion in pancreatic beta
    cells. PLoS Biol, 4(2): p49.
•   Tatum, W. O., Husain, A. M., Benbadis, S. R. (2008). Handbook of EEG Interpretation. Demos Medical Publishing.
•   Niedermeyer E. and da Silva F.L. (2004). Electroencephalography: Basic Principles, Clinical Applications, and Related
    Fields. Lippincot Williams & Wilkins.
•   Rubboli, G., Parra, J., Seri, S., Takahashi, T., & Thomas, P. (2004). EEG diagnostic procedures and special investigations in
    the assessment of photosensitivity. Epilepsia, 45(s1), p35-39.
•   Appleton, R., Macleod ,S., Martland ,T. (2008). Drug management for acute tonic-clonic convulsions including
    convulsive status epilepticus in children. Cochrane Database of Systematic Reviews, 4: CD001905
•   Randell T. (2004). "Medical and legal considerations of brain death". Acta Anaesthesiologica Scandinavica 48 (2): 139–
    144
•   Wijdicks EF. Determining brain death in adults. Neurology. 1995 May; 45(5): pp.1003-11
•   Kupfer, D. J., Foster, F. G., Coble, P., McPartland, R. J., and Ulrich, R. F. (1978). The application of EEG sleep for the
    differential diagnosis of affective disorders Am J Psychiatry 1978; 135:69-74
•   Otto, K. A. (2008). EEG power spectrum analysis for monitoring depth of anaesthesia during experimental surgery; Lab
    Anim , 42: pp. 45-61.
•   Sterman, M.B.; Friar, L. (1972). "Suppression of seizures in an epileptic following sensorimotor EEG feedback
    training". Electroencephalogr Clin Neurophysiol 33 (1): 89–95
•   Basic concepts and clinical findings in the treatment of seizure disorders with EEG operant conditioning". Clin
    Electroencephalogr 31 (1): 45–55.
•   Hammond, Corydon D. "Neurofeedback Treatment of Depression and Anxiety." Journal of Adult Development, Vol 12,
    Nos. 2/3, August 2005
•   Gastaut, H. (1952). "Etude electrocorticographique de al reactivite des rhytmes rolandiques". Rev. Neurol 87 (2): 176–
    182
•   Sny-der et al. (2008). Blinded, multi-center val-i-da-tion of EEG and rat-ing scales in iden-ti-fy-ing ADHD within a
    clin-i-cal sam-ple. Psy-chi-a-try Research, 159, 346–358
References
•   Caat, M. T., Lorist, M. M., Bezdan, E., Roerdink, J. B., & Mauritis, N. M. (2008). High-Density EEG Coherence Analysis Using
    Functional Units Applied to Mental Fatigue. Journal of Neuroscience Methods, 17, pp. 271-278.
•   Nuwer, M,, et al, (2005). Routine and Quantitative EEG in Mild Traumatic Brain Injury; Clinical Neurophysiology, 116.
•   Thatcher, R.W., Camacho, M,, Salazar, A, Linden, C., Biver, C. and Clarke, L.: Quantitative MRI of Gray-White Matter
    Distribution in Traumatic Brain Injury. Journal of Neurotrauma, Volume 14, No. 1, 1-14, 1997
•   Thatcher, R.W., Moore, N, John, E.R., et al.: QEEG and Traumatic Brain Injury: Rebuttal of the American Academy of
    Neurology 1997. A Report by the EEG and Clinical Neuroscience Society, Clinical Electroencephalography, 30(3): 94-98,
    1999
•   Khodayari-Rostamabad, A., Hasey, G. M., Maccrimmon, D. J., Reilly, J. P., & de Bruin, H. (2010). A pilot study to
    determine whether machine learning methodologies using pre-treatment electroencephalography can predict the
    symptomatic response to clozapine therapy. Clinical Neurophysiology, 121(12), 1998–2006
•   Baskaran, A., Milev, R., & McIntyre, R. S. (2012). The neurobiology of the EEG biomarker as a predictor of treatment
    response in depression. Neuropharmacology, 63(4), 507–13
•   Thompson, L. et al (2010). Neurofeedback outcomes in clients with Asperger’s syndrome. Applied psychophysiology
    and biofeedback, 35(1), 63–8
•   Kouijzer, M., et al. (2009). Neurofeedback Treatment for Autism Spectrum Disorders: Scientific Found- ations and
    Clinical Practice. Autism Spectrum Disorders – From Genes to Environment (p. 101–122)




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Medical and pharmaceutical applications of mobile EEG (brain scanning)

  • 1. Personal Neuro Devices: Medical applications of 11/2/2012 mobile EEG 1
  • 2. Electroencephalography (EEG)  Reads brain activity  Neurofeedback therapy  Can track aspects of thought, emotion 11/2/2012 2
  • 3. Mobile EEG  Not bound to lab  Links to smartphone  Makes EEG monitoring available anywhere  Currently mostly for games 11/2/2012 3
  • 4. PND: mobile EEG software  Mobile EEG beyond games  Treatment, diagnostics, self- monitoring  Team  neuroscientists  software engineers  biomedical engineers  business development experts 11/2/2012 4
  • 5. PND technologies: BackupBrain  Stores EEG info online  Accessible anywhere  Deeper analysis 11/2/2012 5
  • 6. PND technologies: Amygdala  Backend for non-game mobile EEG software  Streamlines mobile EEG development  Algorithms, built-in GUIs, links to BackupBrain, etc. 11/2/2012 6
  • 7. Proof-of-concept: Transcend  Neurofeedback-based mobile meditation app  Comprehensive meditation tracking & analysis  Reads relaxation, concentration, meditation  uses in-house algorithms
  • 8. Introspect  EEG self-monitoring  Records mental states via EEG waveform analysis
  • 9. Introspect  Detects: (e.g.)  Mood  Anxiety  Stress  Acute cognitive functioning  Sleep quality Example waveforms linked to mental states  Concentration  Pain „unpleasantness‟
  • 10. Introspect  Detects problem areas  Built-in neurofeedback exercises to improve specific areas PND neurofeedback game: 11/2/2012 psych showdown 10
  • 11. Neurofeedback  Training to directly alter EEG output  Mindfulness-based  Meditation  Effective treatment  ADHD  depression  Anxiety  etc. 11/2/2012 11
  • 12. PND: Pharmaceutical uses  Based on adaptations of Introspect  Introspect malleable for  Research  Diagnostics  Treatment  Etc.
  • 13. PND: Pharmaceutical uses 1) New drug testing  mobile real-time drug efficacy monitoring  E.g. observe mood in brain over time
  • 14. PND: Pharmaceutical uses 2) Aid patient-specific drug selection  EEG patterns linked to disorder etiologies  Help hospital funding 11/2/2012 14
  • 15. PND: Pharmaceutical uses 3) Monitor patient progress  Ensure continued symptom control  Change treatments as needed Example mood and anxiety chart 11/2/2012 15
  • 16. PND: Pharmaceutical uses 4) Augment treatments  Raise overall efficacy  Neurofeedback 11/2/2012 16
  • 17. PND: Pharmaceutical uses 5) New class of as- needed meds  Alarm for impending “attack”  Preventative drug used upon alarm 11/2/2012 17
  • 18. PND: Pharmaceutical uses 6) Preventative medicine  Catch “slipping” mental health before disorder develops
  • 19. PND: Pharmaceutical uses 7) Diagnostics  Link day-to-day mental states to disorders  Reduce reliance on self-report 11/2/2012 19
  • 21. References • MacDonald, P. E., Rorsman, P. (2006). Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells. PLoS Biol, 4(2): p49. • Tatum, W. O., Husain, A. M., Benbadis, S. R. (2008). Handbook of EEG Interpretation. Demos Medical Publishing. • Niedermeyer E. and da Silva F.L. (2004). Electroencephalography: Basic Principles, Clinical Applications, and Related Fields. Lippincot Williams & Wilkins. • Rubboli, G., Parra, J., Seri, S., Takahashi, T., & Thomas, P. (2004). EEG diagnostic procedures and special investigations in the assessment of photosensitivity. Epilepsia, 45(s1), p35-39. • Appleton, R., Macleod ,S., Martland ,T. (2008). Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children. Cochrane Database of Systematic Reviews, 4: CD001905 • Randell T. (2004). "Medical and legal considerations of brain death". Acta Anaesthesiologica Scandinavica 48 (2): 139– 144 • Wijdicks EF. Determining brain death in adults. Neurology. 1995 May; 45(5): pp.1003-11 • Kupfer, D. J., Foster, F. G., Coble, P., McPartland, R. J., and Ulrich, R. F. (1978). The application of EEG sleep for the differential diagnosis of affective disorders Am J Psychiatry 1978; 135:69-74 • Otto, K. A. (2008). EEG power spectrum analysis for monitoring depth of anaesthesia during experimental surgery; Lab Anim , 42: pp. 45-61. • Sterman, M.B.; Friar, L. (1972). "Suppression of seizures in an epileptic following sensorimotor EEG feedback training". Electroencephalogr Clin Neurophysiol 33 (1): 89–95 • Basic concepts and clinical findings in the treatment of seizure disorders with EEG operant conditioning". Clin Electroencephalogr 31 (1): 45–55. • Hammond, Corydon D. "Neurofeedback Treatment of Depression and Anxiety." Journal of Adult Development, Vol 12, Nos. 2/3, August 2005 • Gastaut, H. (1952). "Etude electrocorticographique de al reactivite des rhytmes rolandiques". Rev. Neurol 87 (2): 176– 182 • Sny-der et al. (2008). Blinded, multi-center val-i-da-tion of EEG and rat-ing scales in iden-ti-fy-ing ADHD within a clin-i-cal sam-ple. Psy-chi-a-try Research, 159, 346–358
  • 22. References • Caat, M. T., Lorist, M. M., Bezdan, E., Roerdink, J. B., & Mauritis, N. M. (2008). High-Density EEG Coherence Analysis Using Functional Units Applied to Mental Fatigue. Journal of Neuroscience Methods, 17, pp. 271-278. • Nuwer, M,, et al, (2005). Routine and Quantitative EEG in Mild Traumatic Brain Injury; Clinical Neurophysiology, 116. • Thatcher, R.W., Camacho, M,, Salazar, A, Linden, C., Biver, C. and Clarke, L.: Quantitative MRI of Gray-White Matter Distribution in Traumatic Brain Injury. Journal of Neurotrauma, Volume 14, No. 1, 1-14, 1997 • Thatcher, R.W., Moore, N, John, E.R., et al.: QEEG and Traumatic Brain Injury: Rebuttal of the American Academy of Neurology 1997. A Report by the EEG and Clinical Neuroscience Society, Clinical Electroencephalography, 30(3): 94-98, 1999 • Khodayari-Rostamabad, A., Hasey, G. M., Maccrimmon, D. J., Reilly, J. P., & de Bruin, H. (2010). A pilot study to determine whether machine learning methodologies using pre-treatment electroencephalography can predict the symptomatic response to clozapine therapy. Clinical Neurophysiology, 121(12), 1998–2006 • Baskaran, A., Milev, R., & McIntyre, R. S. (2012). The neurobiology of the EEG biomarker as a predictor of treatment response in depression. Neuropharmacology, 63(4), 507–13 • Thompson, L. et al (2010). Neurofeedback outcomes in clients with Asperger’s syndrome. Applied psychophysiology and biofeedback, 35(1), 63–8 • Kouijzer, M., et al. (2009). Neurofeedback Treatment for Autism Spectrum Disorders: Scientific Found- ations and Clinical Practice. Autism Spectrum Disorders – From Genes to Environment (p. 101–122) More available on request

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