Electrophysiological tests for the CNS
Summary

Concept
Positioning
   • High Quality Service
   • Central Nervous System
   • Functional Electrophysiology
   • ...
Concept

NEUROSERVICE provides advanced tests and expertise
    in Functional Electrophysiology for the CNS :

 In vitro p...
Positioning

                   Functional
               Electrophysiology




High Skill                            High...
High Quality Service


  Flexibility         Short time
Expert support         process



                                ...
Central Nervous System


Acute brain     CNS disorders
  slices



                                  A wide range
        ...
Functional Electrophysiology


  Standardized     Customized
    protocols       protocols



                            ...
High Skill Expertise



Electrophysiology   Drug Discovery




                                      A High Expertise
    ...
Studies

Molecules effects on neurons and neuronal networks
Targets & mechanisms of action
Interaction of a new molecule w...
Models

   Hippocampal slices (glutamat- & GABAergic neurons in
DG, CA3, CA1)
   Cerebellar slices (Purkinje GABAergic lar...
Portfolio Tests 1/3

Test #   Reference compound Target               Associated pathologies
P-001    Tetrodotoxin       S...
Portfolio Tests 2/3

P-007   DHPG            mGluR 1/5 receptors      Stroke
                                             ...
Portfolio Tests 3/3

 P-012   R-α-methylhistamine   H3 histamine receptor    Cognitive Disorders
                         ...
Scope


Addiction                                       P-007, P-014
Alzheimer’s Disease                             P-003...
Commitments

Robust and reproduceable data

High Quality service

Short time processes

Mid-throughoutput

Expert support
...
Benefits


Cost & Time saving

Risk reducing

Efficiency in scientific analysis

Tests capacity

Flexibility
Our Goal




To provide you with the best
      quality services in
Electrophysiological tests for
  the CNS to empower yo...
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Neuroservice Presentation Nov 08 [Mode De Compatibilité]

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Neuroservice Presentation Nov 08 [Mode De Compatibilité]

  1. 1. Electrophysiological tests for the CNS
  2. 2. Summary Concept Positioning • High Quality Service • Central Nervous System • Functional Electrophysiology • High Skill Expertise Studies • Models • Portfolio • Scope Commitments Benefits Goal
  3. 3. Concept NEUROSERVICE provides advanced tests and expertise in Functional Electrophysiology for the CNS : In vitro physiology Acute Brain Slices recording : MEA, Patch-Clamp Standardized & Customised tests 1.2 Normalized fEPSP 1.0 0.8 0.6 0.4 0.2 0.0 n = 5 electrodes (one slice) 0.001 0.01 0.1 1 10 100 [NBQX] in µM
  4. 4. Positioning Functional Electrophysiology High Skill High Quality Expertise Service Central Nervous System
  5. 5. High Quality Service Flexibility Short time Expert support process The best quality of Service to satisfy your needs Reliability Quality Insurance of tests & Confidentiality
  6. 6. Central Nervous System Acute brain CNS disorders slices A wide range of recordings to fit your needs Single neuron Targets
  7. 7. Functional Electrophysiology Standardized Customized protocols protocols The best Electrophysiology to empower your scientific analysis Mid troughoutput MEA&Patch recording
  8. 8. High Skill Expertise Electrophysiology Drug Discovery A High Expertise to fulfill your needs Neuro Neuro Pharmacology Physiology
  9. 9. Studies Molecules effects on neurons and neuronal networks Targets & mechanisms of action Interaction of a new molecule with an existing drug Compound profiling Transgenic mice phenotyping Consulting 1.2 Normalized fEPSP 1.0 0.8 0.6 0.4 0.2 0.0 n = 5 electrodes (one slice) 0.001 0.01 0.1 1 10 100 [NBQX] in µM
  10. 10. Models Hippocampal slices (glutamat- & GABAergic neurons in DG, CA3, CA1) Cerebellar slices (Purkinje GABAergic large neurons) Substantia Nigra (Dopaminergic neurons of pars compacta) Cortex slices (glutamat- & GABAergic neurons in 5-6 layers) Raphe nucleus (Serotoninergic neurons) Thalamus & cortex Striatum & brainstem Spinal Cord
  11. 11. Portfolio Tests 1/3 Test # Reference compound Target Associated pathologies P-001 Tetrodotoxin Sodium channel Epilepsy Pain and Neuropathic Pain Huntington’s Disease Multiple Sclerosis P-002 NBQX AMPA/KA receptors Stroke Epilepsy Amyotrophic Lateral Sclerosis P-003 D-AP5 NMDA receptor Alzheimer’s Disease Parkinson’s Disease Huntington’s Disease Schizophrenia P-004 Bicuculline GABA-A receptors Epilepsy Anxiety Sleep Disorders P-005 Ganaxolone GABA-A receptors Epilepsy Anxiety Sleep disorders P-006 Gabazin GABA-A receptors Epilepsy Anxiety Sleep Disorders
  12. 12. Portfolio Tests 2/3 P-007 DHPG mGluR 1/5 receptors Stroke Epilepsy Neurodegeneration Addiction Anxiety Pain Management P-008 Kainate AMPA/kainate receptors Stroke Epilepsy Pain Cognitive Dysfunctions P-009 Nifedipine L-Type VDCC Stroke Cognitive Dysfunctions Epilepsy Depression P-010 Physostigmine Acetylcholinesterase Alzheimer’s Disease Dementia Cognitive Dysfunction Attention Deficits Disorders P-011 Memantine NMDA receptor Alzheimer’s Disease nicotinic receptors Parkinson’s Disease Dementia
  13. 13. Portfolio Tests 3/3 P-012 R-α-methylhistamine H3 histamine receptor Cognitive Disorders Alzheimer’s Disease Parkinson’s Disease Hyperactivity and Attention Deficit Disorders Sleep Disorders Obesity Epilepsy P-013 Pyrilamine H1 histamine receptors Ranitidine H2 histamine receptors P-014 DCG-IV mGluR2 receptor Obsessive-Compulsive Disorders Anxiety/Stress Disorders Drug/Alcool Addiction P-015 SCH23390 D1 dopamine receptor Cognitive Dysfunction D5 dopamine receptor Parkinson's Disease P-016 Phenytoin K+ channels Epilepsy Carbamazepine P-017 Carbamazepine NMDA receptor Epilepsy Phenytoin P-018 Somatostatin GABA-A receptor Epilepsy P-019 Diazepam GABA-A receptor Epilepsy
  14. 14. Scope Addiction P-007, P-014 Alzheimer’s Disease P-003, P-010, P-011, P-012 Amyotrophic Lateral Sclerosis P-002 Anxiety P-004, P-005, P-006, P-007, P-014 Cognitive Disorders P-008, P-009, P-010, P-012, P-015 Dementia P-010, P-011 Depression P-009 Epilepsy P-001, P-002, P-004, P-005, P-006, P-007, P-008, P-009, P-012, P-016, P-017, P-018, P-019 Huntington’s Disease P-003 Hyperactivity and Attention Deficit Disorders P-010, P-012 Multiple Sclerosis P-001 Neurodegeneration P-007 Neuropathic Pain P-001 Obsessive-Compulsive Disorders P-014 Pain P-001, P-007, P-008 Parkinson’s Disease P-003, P-011, P-012, P-015 Schizophrenia P-003 Sleep Disorders P-004, P-005, P-006, P-012 Stroke P-002, P-007, P-008, P-009
  15. 15. Commitments Robust and reproduceable data High Quality service Short time processes Mid-throughoutput Expert support Confidentiality
  16. 16. Benefits Cost & Time saving Risk reducing Efficiency in scientific analysis Tests capacity Flexibility
  17. 17. Our Goal To provide you with the best quality services in Electrophysiological tests for the CNS to empower your Science.

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