Recognizing rumination in yourself

Recognizing
Rumination In
Yourself
11/17/2018
Ajaz S. Hussain, Ph.D.

Recognizing Rumination In Yourself
View Post Saturday November 17th, 2018
Why do we post - to look good, be good, do good or to
see good?
3 Reactions 2 Comments
Social media posts are social behavior.
Just turn your tears to laughter And joy will follow after
If May days you remember You’ll soon forget December
Instead of asking pity Just say you’re sitting pretty Then
you will see that life will be A wondrous melody
............................ Soon I’ll sail away, sail to old Bombay
Where your arms and your charms will hold me Skies of
fairest blue, eyes of rarest hue Haunt me, taunt me
endlessly Tantalizing lights I’m heeding your call
Oriental nights I love most of all When I’m there I’ll pray
I can always stay With you near in my dear Bombay
With You, Dear, in Bombay
Naturally, Verdoux’s claim did not nd favor with the
censorship o cials. The following lines were deleted
from the speech: “To be shocked by the nature of my
crime is nothing but a pretense… a sham! You wallow in
murder… you legalize it… you adorn it with gold braid!
You celebrate it and parade it! Killing is the enterprise
by which your System prospers, upon which your
industry thrive.
How does rumination di er from emotional processing?

A good reminder.
Our knowledge has made us cynical. Our cleverness,
hard and unkind. We think too much and feel too little.
I am what I am: an individual, unique and di erent.
Wars, con ict, it's all business. "One murder makes a
villain. Millions a hero". Numbers sanctify.
I remain just one thing, and one thing only — and that
is a clown; it places me on a far higher plane than any
politician.
In this image, William Wimley, an NIH-supported
researcher at Tulane University, New Orleans, has
stirred up the soup and will soon add some peptides.
These peptides aren’t made by our cells, though.
They’re synthesized in the lab, allowing Wimley and
team to tweak their chemical structures and hopefully
create ones with therapeutic potential, particularly as
smart-delivery systems to target cells with greater
precision and deliver biological cargoes such as drugs.

Pictures
The new de nition of a kilogram is based on a physical
constant in quantum physics.
What are the skill requirements most consistently
associated with hiring di culties? In manufacturing, it’s
higher-level reading, while for help-desk technicians it’s
higher-level writing.
We see a cooling trend,” says Martin Mlynczak of
NASA’s Langley Research Center. “High above Earth’s
surface, near the edge of space, our atmosphere is
losing heat energy. "If current trends continue, it could
soon set a Space Age record for cold.”

View Post Friday November 16th, 2018
Globalization and Complexity- Ilya Prigogine, Nobel
laureate
We are underestimating severity or has the complexity
increased exponentially? This is not the climactic scene
of an apocalyptic horror movie, set far in the future.
This is California in 2018.
Meteor shower starting earlier than predicted? You
should see the video at link below. "A giant ball like a
meteorite changed the rainbow spectrum of colors
until it turned into a beautiful turquoise," Miron said.
"I've seen shooting stars, but this was HUGE and
colorful!"

Be vigilant and stand your ground while in the air.
Incidence of sexual assaults in the air have spiked.
The predictions were way o , underestimated this
snow storm.
“One of the Commission’s biggest goals is to keep
Frederick looking like it did in the 1800s,” said Kaitlyn
Shorter, the education and research center coordinator
for the Historical Society of Frederick County. “And that
pushed a lot of companies out as they encouraged
smaller businesses to move downtown.”

“Love is action. All else is a reaction.” – Mayan saying
Last week, the northern Californian town of Paradise
was a thriving community of some 27,000 residents,
nestled in the foothills of the Sierra Nevada mountains.
In close recess and secret conclave sat A thousand
Demy-Gods on golden seat's, Frequent and full. After
short silence then And summons read, the great
consult began. For nearly 350 years, Milton's Paradise
Los has held generation upon generation of audiences
in rapt attention, and its profound in uence can be
seen in almost every corner of Western culture.
“Awake, arise or be forever fall’n.” John Milton, Paradise
Lost
“The mind is its own place, and in itself can make a
heaven of hell, a hell of heaven..” John Milton, Paradise
Lost

Recurring errors and inability to correct and prevent
obvious deviations is a sure signal of systemic
weakness. The need for professional development
remains acute. Unfortunately - GMP inspections are so
dependent on the inspector; I am concerned that
recent Zero 483's (observations) will be used by many
to rationalize "all is well". Check out (on the internet)
the report entitled: A big Indian generics maker failed
an FDA inspection, but how bad was it? By ED
SILVERMAN @Pharmalot NOVEMBER 15, 2018 During
their visit, last month to the facility in Visakhapatnam,
India, FDA inspectors found what are called multiple
repeat observations of various problems, which is
regulatory parlance for manufacturing ga es that were
noted during previous inspections. In fact, half of the
quality control problems that were seen had been
spotted when FDA sta visited more than a year earlier.
Wake-up my billionaire friends.
Delay - to- Immediate Action Deny- to- Acknowledge
De ect- to- Responsibility Between stimulus and
response there is a space, it is the intersection of our
feeling, knowing and design space. In this space is our
suitability and capability to be responsible for the kind
we do.
My response at 4th Order of Consciousness: Cowards
My response at 5th Order of Consciousness: They are
sending a strong message; lets nd ways to appreciate
the pain and disease being caused by the political
divide and focus on solving problems.

Pictures
Nearly 30% of opioid prescriptions lack valid medical
justi cation
Epigenetics
Pictures

Mothers who clean soothers by sucking on them have
infants with a lower allergic response, according to new
research conducted by scientists from Henry Ford
Hospital in Detroit. The lead author of the new study,
allergist Eliane Abou-Jaoude, will be presenting her
team’s ndings at the annual meeting of the American
College of Allergy, Asthma, and Immunology (ACAAI),
which is being held in Seattle this week.
Heparin and enoxaprin (and other drug) shortages? The
news is especially concerning for o cials as Sichuan is
the top swine-producing region in China -- a country
that produces half of the world's pigs with a current
population of around 500 million swine.
Saturday, about 3 a.m. ET, will have less moonlight
obstructing the view of the meteors in the United
States.

Between 6 a.m. and 3 p.m., Troopers from the
Maryland State Police responded to 323 crashes,
helped 163 disable vehicles and handled 715 calls
around the state. Some crashes that law enforcement
o cials responded to include a dump truck crash on I-
70 Eastbound at Route 180 and a tractor trailer that
went over an embankment on US Route 340 South of
the Leesburg split.
The symmetries that govern the world of elementary
particles at the most elementary level could be radically
di erent from what has so far been thought. This
surprising conclusion emerges from new work
published by theoreticians from Warsaw and Potsdam.
Superpowers- this thin material claims to put you in
touch with Earth's magnetic elds.

". . . the sign said, 'The words of the prophets are
written on the subway walls......"
Today I started working on an legally defensible
evidence architecture that I hope will discourage or
prevent situations such as this case example. I know
this will be my last contribution to regulatory science
and it will take all of my experiences. Two important
bookends of my experience relevant here are
Cincinnati and Neuchatel. Daubert v. Merrell Dow
Pharmaceuticals, Inc., 509 U.S. 579, is a United States
Supreme Court case determining the standard for
admitting expert testimony in federal courts. And The
smoking gun
https://www.newscientist.com/article/mg16021654-
700-the-smoking-gun/amp/

From Sounds of Silence to Tujhse Naraz Nahi Zindagi by
the Legendary Lata Mangeshkar.

a young Indians.
a young Pakistani.

When you're weary, feeling small When tears are in
your eyes, I'll dry them all (all) I'm on your side, oh,
when times get rough And friends just can't be found
Like a bridge over troubled water I will lay me down
Like a bridge over troubled water I will lay me down
When you're down and out When you're on the street
When evening falls so hard I will comfort you (ooo) I'll
take your part, oh, when darkness comes And pain is all
around Like a bridge over troubled water I will lay me
down Like a bridge over troubled water I will lay me
down Sail on silver girl Sail…
What is It all but Luminous: Notes from an
underground man. Art Garfunkel

I believe this was 1981 - the year I came to America.
Sound of silence- space in between two notes. Hello
darkness, my old friend I've come to talk with you again
Because a vision softly creeping Left its seeds while I
was sleeping And the vision that was planted in my
brain Still remains Within the sound of silence In
restless dreams I walked alone Narrow streets of
cobblestone 'Neath the halo of a street lamp I turned
my collar to the cold and damp When my eyes were
stabbed by the ash of a neon light That split the night
And touched the sound of silence And in the naked
light I saw Ten thousand… This song, in my heart for
decades. Still searching why.
Personalized medicine, precision medicine,
theranostics - personalized development, personalized
reality.

Pharmaceutical polymorphisms, time crystals,
conciousness and good in GLP, GDP and GMP?
Anirban Bandyopadhyay on time crystals and
conciousness. Sound of silence- space in between two
notes.
An anestheologist's view on arti cial neural networks
and conciousness. Science of Consciousness at
University of Arizona.

Arrow of time emerges from within- biocentric?
Sir Roger Penrose in 2017.

Sir Roger Penrose in 2013
Time-crystals to conciousness - A useful perspective.

Time Crystals by a common Joe.
Time crystals by MIT Professor Frank Wilczek (Nobel
laureate).
The laws of physics are not only symmetrical in space
but also in time. And that raises the interesting
question of whether it is possible to break temporal
symmetry in the same way. In other words, is it
possible to create time crystals? YES.

Why higher dimensions are needed to describe 3D
reality? But we don't need to, have to or want to admit
it - is a paradox. Perhaps "time-crystals" can show a
way to resolve this paradox.
T-Mobile's clever new campaign. I like the symbolism in
their advertisement.
There's something unusual – and very, very hot – going
on beneath the ice sheets of Antarctica. A new study
has shown that the Antarctic Ice Sheet at the South Pole
has a giant “hotspot” – triple the size of London – under
its bedrock. Something Strange And Hot Is Lurking
Beneath Antarctica's Ice | IFLScience
https://www.i science.com/environment/something-
strange-and-hot-is-lurking-beneath-antarcticas-ice/
Anomalously high geothermal ux near the South Pole
| Scienti c Reports Local geothermal ux anomalies
could be more widespread in East Antarctica. Assessing
their in uence on subglacial hydrology and ice sheet
dynamics requires new detailed geophysical
observations, especially in candidate areas for deep ice
core drilling and at the onset of major ice streams.
https://www.nature.com/articles/s41598-018-35182-0

Center for Disease Control struggling to investigate the
root cause and to reccomend e ective Corrective and
Preventive Actions. The basic elements of process
control are missing or not understood at the highest
levels of society. Design and Systems thinking is a
higher Order of Consciousness.
Pictures
Pictures
"Function of language is to link interface conditions."
What does it mean?

View Post Thursday November 15th, 2018
This brings back memories- 1977! Previous visit to
Brooklyn had reminded me of those disco days.
Bee Gees Massachusetts; prefer this (recorded) version ؎

Massachusetts by Bee Fees. ؎
Massachusetts has my vote.
"In medical, you are seeing people do more of that
investment internally … because they are 100%
convinced, and rightly so, that it will be a core part of
their business in ve to 10 years," Michael Harmon,
global leader of ISG's engineering services practice, told
MedTech Dive.
Desperately wanting to Look Good. They need a new
Board of Directors with a subcommittee on
Conciousness and Development.

Pictures
Per uoroalkyl substances (PFASs) are a class of man-
made chemicals that are very persistent in the
environment and in the human body. They do not
break down when exposed to air, water or sunlight.
Possibly linked to obesity.
Meet the scientists who have successfully crafted a
research career out of their non-academic interests.
They share strategies for nding funding, carving out
time for your passion while studying and persevering
when other people just don’t see the connection.
Stuart Kau man- I enjoy his thinking.

Interesting exploration of interrelationships.
Rumors aside, there’s little doubt Novartis needs some
sort of strategy change for Sandoz. Narasimhan said as
much in May, when he admitted to investors that
Sandoz is performing well in Europe, particularly in
biosimilars and branded generics, but that the
company has failed to nd an e ective strategy for
dealing with plummeting prices on generic pills in the
U.S. and slow uptake of biosimilars.
Useful

Nassim is not a "main stream" physicist and that I think
is why his apprach is so refreshing. About Haramein
https://resonance.is/about-haramein/
Ontology of Planck Scale.

Planck scale.
3 inches already. Driving Naaz to the airport will need
extra e ort.

Good progress, thinking how to prepare ValGenesis to
take the next step. Will be inviting new Advisors to join
its Adisory Board.
Elephant in the Room - Hiding in Plain Sight: By
ignorance, choice and design.

Modern science can reasonably be said to have come
into being during the time of Queen Elizabeth I of
England and William Shakespeare. Almost immediately,
it came into con ict with the law. How Science Works -
from my days as a Merrell Dow Scholar at University of
Cincinnati to today, I think about this case: The
Supreme Court, in Daubert v. Merrell Dow
Pharmaceuticals, Inc., acknowledged the importance of
de ning science in terms of its methods as follows:
“‘Science is not an encyclopedic body of knowledge
about the universe. Instead, it represents a process for
proposing and re ning theoretical explanations about
the world that are subject to further testing and
re nement’” (emphasis in original). 509 U.S. 579, 590
(1993) (quoting Brief for the American Association for
the Advancement of Science and the National Academy
of Sciences as Amici Curiae at 7–8).
"Tragedies & Comedies are made of one Alphabet."
Francis Bacon

Sir Francis Bacon, Baron Varulam, Viscount of St. Albans
(1561 – 1621) emerged as the rst candidate to replace
Shakespeare. As a leading gure of the English
Renaissance, he certainly had the biography for it:
educated at Cambridge, widely traveled, Bacon was a
famous philosopher, one of the inventors of the
scienti c method, who also led a literary society. He
was also the ultimate royal insider – in addition to
holding other positions, he was a member of the Privy
Council and held the title of Lord Chancellor. The case
for Bacon’s authorship was rst made by an American
author, Delia Bacon – no relation. While people had
questioned Shakespeare’s authorship, she was the rst
person to name an alternative, though she believed
that Bacon wrote Shakespeare’s plays in collaboration
with other leading minds of the time, like Sir Walter
Raleigh and Edmund Spenser.
Hidden in plain sight- for centuries. Thanks to our
compartmentalized system of education. Shakespeare
juxtaposes not two but three di erent ways of thinking
about weight: weight from the perspective of common
experience, weight from the perspective of early
modern physics, and weight as a metaphor to capture
our sense of moral gravity.
There is arrogance "hidden in plain sight" in "truth
required evidence from the real world". Sir Francis
Bacon, in 1618, was appointed lord chancellor, the
most powerful position in England, and in 1621 he was
created viscount St Albans. Shortly afterwards, he was
charged by parliament with accepting bribes, which he
admitted. He was ned and imprisoned and then
banished from court. Although the king later pardoned
him, this was the end of Bacon's public life. He retired
to his home at Gorhambury in Hertfordshire, where he
continued to write. He died in London on 9 April 1626.

Words are powerful, they carry our intention and
passion. What lies behind our words - Germatia. Good -
new energy and synergy than G+o+o+d.
Supersymmetry links the two di erent classes of
particles known as fermions and bosons. Particles like
those in the Standard Model are classi ed as fermions
or bosons based on a property known as spin.
Fermions all have half of a unit of spin, while the
bosons have 0, 1 or 2 units of spin. Supersymmetry
predicts that each of the particles in the Standard
Model has a partner with a spin that di ers by half of a
unit. So bosons are accompanied by fermions and vice
versa. Linked to their di erences in spin are di erences
in their collective properties. Fermions are very
stando sh; every one must be in a di erent state. On
the other hand, bosons are very clannish; they prefer to
be in the same state. Fermions and bosons seem as
di erent as could be, yet supersymmetry brings the
two types together.
https://home.cern/science/physics/supersymmetry

Pictures
It is a deadly storm.

Many foreign governments have refrained from
speaking out over the Xinjiang situation, with diplomats
saying countries are fearful of angering China, an
increasingly weighty diplomatic player thanks to its
economic heft and initiatives such as the Belt and Road
infrastructure program.
The inclusion of skin disease states in PBPK models will
help pharma companies to develop non-Q1/Q2/Q3
formulations and simulate their in vivo performance in
patient populations to further support their
substitutability in diseased skin. In evaluating
bioequivalence, the FDA uses Q1 to de ne qualitative
equivalence (test and reference products contain the
same active and inactive ingredients), Q2 for
quantitative equivalence (test and reference products
contain the same amounts of active and inactive
ingredients), and Q3 for physicochemical attributes of a
speci c dosage form.
Accumulating rapidly

High-school student to MIT to an engineer and doctoral
candidate. Need to add pictures while at Stanford for
MS degree.
Helping, xing, and serving represents three di erent
ways of seeing life. When you help, you see life as weak.
When you x, you see life as broken. When you serve,
you see life as a whole. Fixing and helping may be the
work of the ego, and service the work of the soul
(Remen RN. Kitchen Table Wisdom: Stories That Heal.
New York: Riverhead Books; 1997). The word
compassion means “to su er with.” Compassionate
care calls physicians to walk with people in the midst of
their pain, to be partners with patients rather than
experts dictating information to them. “Physicians must
be compassionate and empathic in caring for patients.
… In all of their interactions with patients, they must
seek to understand the meaning of the patients' stories
in the context of the patients' beliefs and family and
cultural values.… They must continue to care for dying
patients even when disease-speci c therapy is no
longer available or desired” (Association of American
Medical Colleges 2001).

Caring from the heart....
Dis-eased heart cause of heart disease
Intention is an action of the heart!
A coherent heart is not a metronome since its rhythms
are characterized by dynamic complexity with stability
over longer time-scales. A metronome, from ancient
Greek μέτρον (métron, "measure") and νέμω (némo, "I
manage", "I lead"), is a device that produces an audible
click or other sound at a regular interval that can be set
by the user, typically in beats per minute (BPM).
Musicians use the device to practice playing to a regular
pulse. Metronomes typically include synchronized
visual motion (e.g., swinging pendulum or blinking
lights).
Practical practice method to connect heart and brain:
How to Harmonize Heart and Brain

The autonomic imbalance may be a nal common
pathway to increased morbidity and mortality from a
host of conditions and diseases, including
cardiovascular disease. Heart rate variability (HRV) may
be used to assess autonomic imbalances, diseases, and
mortality.
Free PDF: Heart rate variability: Standards of
measurement, physiological interpretation, and clinical
use.

I used to think while growing up in India, that "by heart"
meant memorization! It is to think by integrating our
heart with our brain and guts.
Riks of dying 5.3 times higher with HR variability of less
than 50 ms compared to HR variability of more than
100 ms. A high degree of heart rate (HR) variability is
found in compensated hearts with good function,
whereas HR variability can be decreased with severe
coronary artery disease, congestive heart failure, aging,
and diabetic neuropathy. The relative risk of mortality
was 5.3 times higher in the group with HR variability of
less than 50 ms than the group with HR variability of
more than 100 ms. HR variability remained a signi cant
predictor of mortality after adjusting for clinical,
demographic, other Holter features and ejection
fraction. A hypothesis to explain this nding is that
decreased HR variability correlates with increased
sympathetic or decreased vagal tone, which may
predispose to ventricular brillation.

First snow of this season.
Events that threaten, frustrate or provoke occur on a
daily basis, yet only a minority of individuals respond
with aggression. During adolescence, ongoing
functional development occurs in neural circuitry
underpinning processes of key relevance to reactive
aggression, including emotional reactivity, emotion
regulation, decision-making, and social reward; as well
as in the response of the ‘aggression network’ itself.
This may at least in part explain the peak in reactive
aggressive behavior seen during these years. However,
since the majority of adolescents do not develop
clinically signi cant reactive aggression, it is important
to understand how individual di erences (in factors
such as irritability or emotional reactivity) may interact
with canonical trajectories of adolescent neurocognitive
trajectories to confer risk or resilience in this area.

Autonomic nervous system (ANS) activity is a core
component of emotion processing. The limbic system
and medial prefrontal cortex play important roles in the
regulation of ANS activity. This study examined the
relations of ANS activity in the parasympathetic
nervous system (PNS) and the sympathetic nervous
system (SNS) with brain activity during emotional face
processing in adolescents. A potential metric for adult
development - ndings implicate the hippocampus for
potentiating SNS activity, document that regulation of
SNS and PNS activity are coordinated with distinct
regions of the medial prefrontal cortex, and suggest
potential developmental di erences in vmPFC
regulation of PNS activity between adolescents and
adults.
Autonomic (subconscious) dysfunction, speci cally low
HRV, can be prospectively implicated in the generation
of depressive symptoms in a non-clinical setting.
Rumination means that you continuously think about
the various aspects of situations that are upsetting

While working in Switzerland on Tobacco Harm
Reduction we were amazed at the value of Heart Rate
Variability (HRV) as a predictive biomarker. HRV is a very
useful biomarker we can use in our day to day e orts
to improve and develop. High HRV is Good, desirable.
Our social behavior is orchestrated by a network of
prefrontal and para-limbic brain regions and are
relevant for a plethora of social processes, implying
that functional and structural changes (HRV as
feedback for development via practice - see the lecture
slides I posted yesterday that relate "Feeling Space" ) in
these brain regions are associated with changes in
social cognition and social interaction. For example,
individuals with high HRV are more likely to recognize
facial expressions of others to regulate emotional
responses towards others and to establish cooperative
relationships with others than individuals with low HRV.
Inter-individual di erences in high-frequency heart rate
variability (HF-HRV) are associated with inter-individual
di erences in social behavior and social cognition. This
study suggests that males with high HF-HRV are more
inclined to engage in cooperative behavior than males
with low HF-HRV. Other useful papers: Kahneman, D.,
Knetsch, J. L. & Thaler, R. H. Fairness and the
assumptions of economics. J Bus S285–S300 (1986).
Fehr, E. & Fischbacher, U. The nature of human
altruism. Nature 425(6960), 785–91 (2003). Henrich, J. et
al. Costly punishment across human societies. Science
312(5781), 1767–70 (2006). Thayer, J. F. & Lane, R. D.
Claude Bernard, and the heart-brain connection:
further elaboration of a model of neurovisceral
integration. Neurosci Biobehav Rev 33(2), 81–8 (2009).
Henrich, J. et al. Markets, religion, community size, and
the evolution of fairness and punishment. Science
327(5972), 1480–1484 (2010).
Who is unkind and easily divided?
Mean means unkind and average - the value obtained
by dividing the sum of several quantities by their
number.
Interesting - the certainty of receiving intercessory
prayer was associated with a higher incidence of
complications.

Intercessory prayer was classi ed as an experimental
intervention. Meta-analysis indicated small, but
signi cant, e ect sizes for the use of intercessory
prayer.
Remote, intercessory prayer was associated with lower
coronary care unit (CCU) course scores. Randomized,
controlled, double-blind, prospective, parallel-group
trial. Nine hundred ninety consecutive patients who
were newly admitted to the CCU. The primary
prede ned endpoint in this trial was the weighted Mid
America Heart Institute (MAHI) -CCU scores.
Intercessory prayer is one of the oldest forms of
therapy.
The "root cause" is human development.

Continuing Quest for Knowledge Despite the recent
clinical success of drugs such as trastuzumab
emtansine (Kadcyla), brentuximab vedotin (Adcetris),
and inotuzumab ozogamicin (Besponsa), the fact is that
we do not yet fully understand how ADCs elicit their
pharmacological e ects in patients. The quest to
develop more e ective and less toxic ADCs continues.
Improved and more predictive preclinical studies
combined with clinical studies of next-generation ADCs
will augment our understanding and ability to develop
agents with improved pharmacological properties,
reduced toxicity, and enhanced e cacy — ultimately
leading to more durable clinical responses in patients.
Virtual Bioequivalence via QMM. A step forward
towards modernizing generic drug development and
supporting regulatory decision‐making. Don't forget the
"real world."
Fatima 21st, Sana, Rashid; Tahseen, Waseem, Naaz
23rd...

Naaz departing for Kochi today.
Pictures
View Post Wednesday November 14th, 2018
The only thing you sometimes have control over is
perspective. Chris Pine
A CAR gene was unintentionally introduced into a single
leukemia cell during the manufacturing process at
Penn. The cancer cell expressing the receptor was
infused back into the patient along with therapeutic
CAR-T cells, where it multiplied. The CAR expressed by
leukemic cells bound the target antigen on the same
cells, masking them from CAR-T cells. This conferred
resistance, and the patient died of leukemia
complications around 20 months after the treatment.
The unique case was rst reported to a National
Institutes of Health advisory committee in 2016.

Three Identical Strangers is a documentary that tells
the amazing story of three identical male triplets who
reunited as young adults after being separated at birth.
The Conspiracy Behind 'Three Identical Strangers' Is
Beyond Messed Up - VICE The documentary about their
lives, Three Identical Strangers, elucidates, the brothers
were part of an elaborate psychological experiment
hatched in the 1960s to study the e ects of nature
versus nurture. Psychiatrists partnered with the Louise
Wise Services adoption agency on a “Twin Study,” which
involved splitting up identical twins and triplets, placing
them in di erent home environments, and studying
their development. Kellman, Shafran, and Galland were
three of their test subjects. No one, except the
scientists who orchestrated the study, know how many
other sets of twins and triplets may be out there,
completely unaware they have long-lost identical
siblings. The results of the study were never released.
When the lead researcher, Dr. Peter Neubauer, died in
2008, all of his records were placed with Yale University
and restricted until 2065, presumably long enough for
anyone involved in the study to have died.
https://www.vice.com/en_us/article/594mek/the-
conspiracy-behind-three-identical-strangers-is-beyond-
messed-up

Slides I used today for my Lecture to Pharmaceutical
Engineering students (MS degree) at Ecole des Mines
d'Albi-Carmaux. Steps for Raising our Order of
Consciousness: 1. Awareness – feeling dissonance,
disorienting dilemma (such as in a crisis) 2.
Reevaluation of beliefs and assumptions 3. Critical
re ection and re ective discourse 4. New outlook and
behaviors Our subconscious and built-in “Prediction
Error” makes is very di cult to be aware of dissonance
we (should) feel, and crisis induces fear. We don’t
challenge our assumptions, we don’t change our set
mind. Continual development is di cult. Common
sense is not so common (Voltaire), because it is the
collection of prejudices acquired by the age of eighteen
(Albert Einstein). Few continue to develop, but at a
di erent rate; many do not! This is how I know to
increase my Order of Consciousness: To consciously go
(actions) beyond traditional education & training to be
self-authored in what we know and (to be self-assured)
how we know it (epistemology). To be self-transforming
(practice, practice) in lling gaps (awareness) between
what we know and what we can implement (awareness,
failures of actions, practice). Feel (dissonance) the need
(multiple perspectives, empathy), know (awareness) the
ways (practices) to leverage our collective (multi-,
transdisciplinary, and multiple systems), experiential
learning (conversation, re ection), and understand
(subconscious and conscious) the multiple contexts
(Pro teer to Patient to Professional to Good
Practitioner), of our abstract nouns (e.g., quality,
assurance, etc.)
February 26, 2017, I was still counting days since I quit
smoking – when I wrote: “It is day 110 since I quit
smoking!” Gave up counting and thinking about it long
since then. On my mind then and now is “Nonsense
News No-sense Nocebo” – it was, and is, my description
of the challenge posed by the increasing irrationality in
our global society and its devastating consequences.
My life has been very privileged; I enjoy real friendships
unhindered by any religious dogma. Within our circle of
friends across many religions how have we prevented
the negative in uence of religious dogma? How can I
contribute to a solution? How to go beyond passive
support, such as donations to refugee relief
organizations? To nd a path forward, I seek to pursue
“Bob’s Big Idea” and Gandhi’s “a way out of hell.” The
path forward in 2017 was uncertain – “Fruitful
discussion on #NonsenseNewsNo-senseNocebo will
need to overcome the reactions induced by religious
dogma and other factors. Today I am still ill-prepared
(not knowledgeable) to do so. The path forward is
uncertain. Given my life stage, I must not shy away
from pursuing this challenge.” By end of 2018 I aim to
chart a new path forward; at the moment I sense that I
will transition away from pharmaceuticals as I had
anticipated/envisioned when I wrote the blog entitled
“Schrödinger's Cat & My Journey From 2015 to 2020” “It
is very easy to learn intolerance and unlearn tolerance,
but di cult to unlearn intolerance,” ― Seyyed Hossein
Nasr, In Search of the Sacred

Over 35k views of this slide-deck on Slideshare. A
presentation on 25 May 2012 Basel, Switzerland. I had
accepted a position at Wockhardt and was transitioning
back to Pharma sector from the Tobacco sector. The
presentation provides a philosophical exploration of
scienti c understanding and risk-based regulatory
decisions in the context of Quality by Design. How good
are the scienti c explanations in regulatory
submissions? Scienti c explanations yield
understanding; quality of explanations di er. What role
can Chemometrics, Pharmacometrics and
Econometrics play? Understanding multidisciplinary
(cGMP, CMC, Clin. Pharm., Tox., Clinical, Public Health)
perspectives on risk are important. Opportunities; only
when the disciplinary divides are bridged. Within the
regulatory realm how we set speci cations and assess
risk have progressed incrementally; at this rate, the
Vision 2020 may be expected to be visible broadly over
time, by 2020?
Ecole des Mines d'Albi-Carmaux
https://youtu.be/6aBK72AoTWM
This smells of collusion.

For the rst time, neurosurgeons have implanted
‘reprogrammed’ stem cells into the brain of a patient
with Parkinson’s disease.
Seeing Good is the answer! Higher education is an
exception. “It is an individual decision,” says Saeed, who
has so far found long travel times her only challenge.
Her Israeli co-supervisor, geochemist Boaz Lazar,
helped to organize a multi-entry permit for her to enter
Israel during the daytime, a scholarship courtesy of the
University of Haifa.
Seeing Good in systems that appear to be; and in parts
are de nitely Procrustean and just for Looking Good.
Our Friend Network is ahead of the curve! Social-media
interactions can empower those living with disease, and
their families, to make informed choices about their
health care and clinical trials. Some people have even
united on social media to launch trials of their own.
My ignorance of the "Mysterious 137". Doing something
about it. What is the ne-structure constant? The ne-
structure constant is a unitless numerical constant -
whose value is approximately equal to: 1/137. Symbol
for the ne-structure constant is Greek alpha (). Fine
Structure - closely spaced groups of optical spectrum
lines of elements like: hydrogen and helium. These
optical spectrum lines are in a way the ngerprint of
the element's energy levels. Since the energy levels of
any given element are quantized (i.e. only discrete
energy levels are available) the optical spectrum
appears as a series of lines instead of a continuous
spectrum.

Zika is similar genetically to dengue, they belong to the
same avivirus family and antibodies to one virus
sometimes will bind the other. Both are transmitted by
the same mosquito vector and their geographical
infection patterns overlap in Central and South
America, some parts of Africa and South Asia.
In the real world things are always more dramatic than
in simulations. If we make everyone work as hard as
they can, nishing projects becomes harder and
harder.
Goal has nothing to do with System’s internals. Look for
it outside of the System.

Follow this series.
Part 1 of Identifying And Resolving Errors, Defects, And
Problems Within Your Organization — a ve-part series
on operationalizing proper improvement techniques
To read later.
Good read.
Students trickling in; glad to note increased number of
female engineers.

My parents are my backbone.
Dr. Abubacker, my father (in-law) is ailing. Naaz to
travel asap to Kerala. Keep him in your thoughts and
prayers, please.
Pharmaceutical Leadership for the 21st Century:
Sharing my experiential learning. Wiser today than I
was yesterday; repeat.

Next four hours: Wiser today than I was yesterday,
repeat.
Can not support Bill on this. Bill Gates wants to end
malaria, and so he’s particularly “energized” about gene
drives, a technology that could wipe out the
mosquitoes that spread the disease.
UFO movie shot at University of Cincinnati! Rented it on
YouTube will watch tomorrow afternoon; after my
lecture.
Must see - Gillian Anderson! If a fundamental constant
of the universe called the ne structure constant was
di erent in di erent locations, beings could use the
changing constant to navigate through space.

The little-known nocebo e ect, where negative
expectations about treatment lead to side e ects, can
have a huge impact on clinical outcomes. It is important
that healthcare professionals are aware of the nocebo
e ect and talk to patients about their medicines in a
balanced way so as to try to minimise it.
A recently published editorial linked to a previous
switching study for patients who had been receiving
reference in iximab (Remicade) to biosimilar in iximab
(In ectra) argues that the positive results of the trial
“apparently settles the case in favor of unrestricted
switching of 'expensive' originator to 'cheap' biosimilar
in iximab. Yet, the devil is the details."

In a prospective trial, patients treated with oral valproic
acid for autosomal dominant retinitis pigmentosa had
worse visual eld outcomes than patients treated with
placebo.
Amarin’s placebo used a mineral oil which could
theoretically boost trial participants’ “bad” cholesterol
levels. That could, in turn, make the sh oil’s
performance in reducing cardiovascular risk appear
particularly strong (or so the thinking seems to go
among the more skeptical). Those concerns, however,
may not derail Amarin’s quest to get the Food and Drug
Administration (FDA) to slap a favorable label on
Vascepa (which was approved by the agency six years
ago) showing serious heart health bene ts. Heck, even
the investor fretting eroded over the course of the day.
And Amarin’s chief executive is expressing nothing but
con dence.

Placebo trial conducted by Harvard shows that even
when cancer patients know they are taking a placebo
pill, it helps ght fatigue
Pictures
Pictures
Pictures

Pictures
OK, so modern medicine limits patient encounters to a
maximum 15 minutes. Make them count, writes
Adeleke Adesina, DO.
The trials with a low risk of bias found no bene t to
acute respiratory infections from oral homeopathic
medicines, whereas the high risk of bias trials found
bene cial e ects of homeopathic medicines.
Modern science is uncovering the way the placebo
e ect works, nding clear physical changes produced
by “fake” treatments and genetic in uences that can
make our diseases more or less susceptible to sugar
pills. But this work raises questions about the limits of
Western medicine.

Is FDA ignoring the latest research on placebos in its
new guidelines? Given the ethical challenges of using a
placebo in randomized controlled clinical trials for
therapies to treat hematologic malignancy and
oncologic disease, the US Food and Drug
Administration (FDA) recommends that a sponsor use a
placebo-controlled design only in select circumstances,
according to new draft guidance.
Sign up..
The internet went slightly more bananas than usual
after the New York Times’ story implying that
extraterrestrials are real and the U.S. government has
been tracking them for years.
Main stream media reports on UFOs. The "Disclosure
Community" going bonkers. Facinatiing YouTube videos
- UFO cover-up and possible disclosure scenarios. One
thing is clear: we live in a world that hangs in the
balance.

Expect a "drinking checkup" when you visit the doctor.
All adults, including pregnant women, should be
screened for unhealthy alcohol use by their primary
care physicians, the United States Preventive Services
Task Force advises
This might get ugly. FDA and NTP not on the same
page! (when I was at FDA, the FDA rep to NTP reported
to me).
Kids looking great! Tahseen and Waseem Mohamad.

Grandkids in Delhi dressed for a wedding reception;
sending a message?
Still working on my lecture for 32 Pharmaceutical
Engineering and Biomedical Engineering students in
Albi, France. ‫ل‬
View Post Tuesday November 13th, 2018
An entire industry has cropped up to link drug makers
with the industry’s own version of an in uencer —
people, usually patients, who have small but devoted
followings and who might be willing to promote their
products or share valuable insights about the patient
community. Ciccarella, for example, is one of nearly
100,000 such in uencers on the rosters of Wego
Health, one of a handful of companies that essentially
act a patient in uencer talent agency.

Most acts of courage don’t come from whistleblowers
or organizational martyrs. Instead, they come from
respected insiders at all levels who take action—be it
campaigning for a risky strategic move, pushing to
change an unfair policy, or speaking out against
unethical behavior—because they believe it’s the right
thing to do. Their reputations and track records enable
them to make more headway than those on the
margins or outside the organization could. And when
they manage the process well, they don’t necessarily
pay a high price for their actions; indeed, they may see
their status rise as they create positive change.
Teach not punish.
Need to watch this video.

I am using Facebook as tool to recorded some of my
thoughts and sharing these only with a small group of
friends.
I don't trust any of them.
Surveillance, self, state, and space.
ei incumbit probatio qui negat, non qui dicit
Honest truth about dishonesty.

“Science is a bit like the joke about the drunk who is
looking under a lamppost for a key that he has lost on
the other side of the street, because that’s where the
light is. It has no other choice.”
The streetlight e ect, or the drunkard's search
principle, is a type of observational bias that occurs
when people only search for something where it is
easiest to look.Both names refer to a well-known joke:
A policeman sees a drunk man searching for something
under a streetlight and asks what the drunk has lost.
He says he lost his keys and they both look under the
streetlight together. After a few minutes the policeman
asks if he is sure he lost them here, and the drunk
replies, no, and that he lost them in the park. The
policeman asks why he is searching here, and the
drunk replies, "this is where the light is". The anecdote
goes back at least to the 1920s,
Researchers tend to look for answers where the looking
is good, rather than where the answers are likely to be
hiding

vDISCO makes dead mice transparent and hard like
plastic to give researchers an unprecedented view of
how di erent types of cell interact in the body. Lets
scientists pinpoint speci c tissues within an animal
while scanning its entire body.
Bootstrapping ؎ In many branches of science,
researchers often have to draw conclusions from
limited data. Assessing the level of con dence that
comes with such conclusions is crucial, and often
di cult. In the 1970s, Efron and others realized that the
increased availability of computers would make new,
computationally intensive tests feasible. The bootstrap
was the rst such method. It slices up a data sample in
random ways and calculates whether a conclusion —
such as the fact that two variables are strongly
correlated — is solid. “It allows data analysts to use
complicated, sometimes very complicated, methods
and still be able to assess their accuracy,” Efron says.

It can take 20 years or more to get a drug to market,
from testing compounds in animals to running late-
stage (phase III) clinical trials in thousands of subjects.
More than 80% of drugs that are tested in humans fail
to demonstrate safety and e cacy; the rate for
Alzheimer’s treatments is estimated at more than 99%.
A decade’s worth of clinical trials for Alzheimer’s drugs
has identi ed only one approved treatment. Yet most
of the results from the failed studies will never be seen.
The case demonstrates how access to evidence from
disappointing drug-development programmes is
essential to advancing the whole scienti c process,
argue two researchers at the European Medicines
Agency. https://www.nature.com/articles/d41586-018-
07352-7?utm_source=brie ng-
dy&utm_medium=email&utm_campaign=brie ng&utm
_content=20181113
Bacteria from the gut might also take up residence in
our brains, suggest early ndings that neuroscientists
are calling potentially “revolutionary if it’s so”.
Germain is happy to have a home in the U.S.: "I am an
American and I love that. A refugee is a person that lost
everything, has no hope. A refugee is a person who is
looking for a second chance. For me, to be an American
is a big deal… living here is a blessing."

The Oxford Dictionary's word of 2016 was "post-truth.
Pictures
Rot in the system.

View Post Monday November 12th, 2018
Fatima as an undergraduate @ MIT.
Fatima soon to be Dr. Fatima Hussain.
Kids and grandkids. Looking forward to Thanksgiving.

Wisdom traditions.
Need to research this topic. This discussion is alarming

Fourth phase of Water. This new phase, liquid
crystalline water, has many fascinating properties, and
goes a long way in explaining many of the anomalous
properties of water, and of those things which contain a
high percentage of water as a part of their make-up.
The insights described here arose out of a departure
from the mainstream science route. They were gleaned
mainly from simple observations and logical
interpretations.
Can some birds y over Mount Everest? The geese,
Anser indicus, migrate over the Himalayas twice a year
between their summer breeding grounds on the
Mongolian plateau and their winter range in south-
eastern Tibet or India. They are not the only birds to y
so high. The common crane (Grus grus) has been
recorded at 10,000 metres, high enough to avoid
predatory eagles, while the Ruppell’s Vulture (Gyps
rueppellii) has been seen at 11,300 metres.

Mechanism of ight of birds and bees and the role of
water? Do we need to re-think Bernoulli's principle?
Given the weight, what keeps clouds a oat? Earth is
negatively charged due to EZ water? A fourth phase
that occurs at interfaces. The formal name for this
fourth phase is exclusion-zone water, aka EZ water. This
nding may have profound implication for chemistry,
physics, and biology.
Water
Exclusion-zone separates solutes from water, in the
absence of any physical lter.

Very interesting research on water- New knowledge
about Water.
Routine test was not so routine as it needed an
investigation. "Earlier today, a routine test caused users
to have trouble accessing or posting to all Facebook
services including WhatsApp and Instagram. We quickly
investigated and restored access for everyone. We’re
sorry for the inconvenience."
On TV; trying to imagine the situation in reality.

Fasrbook should pay me or just thank me for my e orts
to inject large volume of scienti c information on its
platform to dilute the corrosive prevalence of
misinformation.
A storm with snow, ice and rain will bring travel
disruptions from the Midwest and southern United
States to the Northeast spanning Wednesday night to
Friday. Motorists and airline passengers in much of the
eastern U.S. should be prepared for more delays as a
second winterlike storm for this week runs its course.
A powerful electron-based imaging technique to obtain
an image of atomic-scale structure in a synthetic
polymer.

View PostMonday November 12th,
2018AGU Publications Space
Weather Volume 0, Issue 0
Commentary Free Access On the
Little‐Known Consequences of the 4
August 1972 Ultra‐Fast Coronal Mass
Ejecta: Facts, Commentary, and Call
to Action Delores J. Knipp Brian J.
Fraser M. A. Shea D. F. Smart First
published: 25 October 2018
https://doi.org/10.1029/2018SW002024
About Sections Abstract Today the
extreme space weather events of
early August 1972 are discussed as
benchmarks for Sun‐Earth transit
times of solar ejecta (14.6 hr) and for
solar energetic particle uxes (10
MeV ion ux >70,000 cm−2·s−1·sr−1).
Although the magnetic storm index,
Dst, dipped to only −125 nT, the
magnetopause was observed within
5.2 RE and the plasmapause within 2
RE. Widespread electric‐ and
communication‐grid disturbances
plagued North America late on 4
August
There was an additional e ect, long
buried in the Vietnam War archives
that add credence to the severity of
the storm impact: a nearly
instantaneous, unintended
detonation of dozens of sea mines
south of Hai Phong, North Vietnam
on 4 August 1972. The U.S. Navy
attributed the dramatic event to
magnetic perturbations of solar
storms. Herein we discuss how such
a nding is broadly consistent with
terrestrial e ects and technological
impacts of the 4 August 1972 event
and the propagation of major
eruptive activity from the Sun to the
Earth. We also provide insight into
the solar, geophysical, and military
circumstances of this extraordinary
situation. In our view this storm
deserves a scienti c revisit as a
grand challenge for the space
weather community, as it provides
space‐age terrestrial observations of
what was likely a Carrington‐class
storm. Plain Language Summary The
extreme space weather events of
early August 1972 had signi cant
impact on the U.S. Navy, which have
not been widely reported

These e ects, long buried in the
Vietnam War archives, add credence
to the severity of the storm: a nearly
instantaneous, unintended
detonation of dozens of sea mines
south of Hai Phong, North Vietnam
on 4 August 1972. This event
occurred near the end of the
Vietnam War. The U.S. Navy
attributed the dramatic event to
magnetic perturbations of solar
storms. In researching these events
we determined that the widespread
electric‐ and communication‐grid
disturbances that plagued North
America and the disturbances in
southeast Asia late on 4 August likely
resulted from propagation of major
eruptive activity from the Sun to the
Earth.
Senior o cials of the four countries will discuss ways to
balance China’s growing ambitions in the Indo-Paci c
region, share their perspectives on the geopolitics in
the region, and emphasise on the centrality of ASEAN
for the Quad process, people familiar with the agenda
of the meeting told ET. The US has stepped up its
e orts to hedge China in the Indo-Paci c region, even
as the two largest economies are engaged in a trade
war by slapping tari s on their imports.

This poped up in the list my AI sent me to look at.
Should I revisit this tragedy? Perhaps not; despite it
being "a quintessentially Doctor Who idea that after
su ering the unimaginable loss of their planet and their
people, the Vajarians decided to give up their own
blood-thirst and ensure that no deaths ever went
unwitnessed and unhonored again. It’s also an idea
that helps provide a sense of comfort and peace to a
gutwrenching episode with no real happy ending."
The bene ts of screens as a learning tool are
overblown, and the risks for addiction and stunting
development seem high. The debate in Silicon Valley
now is about how much exposure to phones is O.K.
“Doing no screen time is almost easier than doing a
little,” said Kristin Stecher, a former social computing
researcher married to a Facebook engineer. “If my kids
do get it at all, they just want it more.”

Wow! This is a unfolding story worth keeping an eye on.
Does the "treatment" look so good due to the choice of
the "placebo"? Did the choice of placebo caused harm?
The placebo might have caused harm and in turn
in ated Vascepa’s e ectiveness pro le. In the 8,179-
subject trial, patients in the control arm received a
mineral oil- lled pill to look like Amarin’s puri ed sh-
oil drug. Critics seized upon the fact that these patients
saw some key CV biomarkers trending in a bad way
that should not be observed with normal placebos,
Je eries analyst Michael Yee noted in a Sunday memo
to investors. Patients who got the dummy pill saw their
levels of bad cholesterol—usually associated with
higher heart risks—increase around 10% in the rst
year versus less than 3% changes in the Vascepa group.
Level of high-sensitivity C-reactive protein (hsCRP)—an
indication of in ammation—also increased 30% in the
placebo group.
I don't own any tobacco stocks, any more, nor am I
planning to invest here. But if you have stocks in this
sector expect a big opportunity emerging soon. Do your
research.
50 varieties of oil and vinegar ranging from black tru e
oil to jalapeno white vinegar.

A chocolate boutique that hand crafts each chocolate
here in Frederick.
Facebook, Snapchat, and Instagram use decrease well-
being. Psychologist Melissa G. Hunt publishedin the
Journal of Social and Clinical Psychology. Use it as a
note keeper instead of looking for "likes".
Facebook, Snapchat, and Instagram use decrease well-
being. Psychologist Melissa G. Hunt publishedin the
Journal of Social and Clinical Psychology. Use it as a
note keeper instead of looking for "likes".
Spending too much time on “social media” sites like
Facebook is making people more than just miserable. It
may also be making them depressed. A new study
conducted by psychologists at the University of
Pennsylvania has shown — for the rst time — a causal
link between time spent on social media and
depression and loneliness, the researchers said.

Strategy is based on the premise that treatments
reduce the number of micro larial parasites circulating
in the blood to a level at which transmission by
mosquitoes is not sustainable. Mass drug
administration is recommended by the WHO to be
undertaken for a period of at least 5 years with an
epidemiologic coverage of at least 65% of the total
population. Mosquito vector control is an important
supplemental intervention aimed at breaking
transmission.
By the numbers: The health care industry's $50 billion
of pro t came from $636 billion of revenue, equating to
a cumulative pro t margin of almost 8%. Those are the
highest gures of the past four quarters. Approximately
63% of the pro t total went to drug companies, even
though they collected 23% of the revenue — numbers
that mirror our past analyses.

Nature Brie ngs Subscribe https://us17.campaign-
archive.com/?
u=2c6057c528fdc6f73fa196d9d&id=2a106ba209&e= 1
e56a9e8
According to data from the NIFC, there has been a clear
trend in increased area burned by wild res in the US
since the 1980s, when reliable US-wide estimates based
on re situation reports from federal and state
agencies became available. Today, wild res are burning
more than twice the area than in the 1980s and 1990s.
These gures include all wildland res in both forested
and non-forested areas. Most of the area burned today
is in the western US, where dryer conditions tend to
allow for large, quickly-spreading wild res.

Lymphatic lariasis, commonly known as elephantiasis,
is a painful and profoundly dis guring disease. In
communities where lariasis is transmitted, all ages are
a ected. While the infection may be acquired during
childhood its visible manifestations may occur later in
life, causing temporary or permanent disability. In
endemic countries, lymphatic lariasis has a major
social and economic impact with an estimated annual
loss of $1 billion and impairing economic activity up to
88% (Katabarwa M et al. 2008). The disease is caused by
three species of thread-like nematode worms, known
as lariae – Wuchereria bancrofti, Brugia malayi and
Brugia timori. Male worms are about 3–4 centimetres in
length, and female worms 8–10 centimetres. The male
and female worms together form “nests” in the human
lymphatic system, the network of nodes and vessels
that maintain the delicate uid balance between blood
and body tissues. The lymphatic system is an essential
component of the body’s immune system.
The record speaks for itself. What did John J.
Mearsheimer document in The Great Delusion: Liberal
Dreams and International Realities? No time to read
this: save for later.
In February — three years after Moore's death — her
badly decomposed body was found stashed in a locked,
unrefrigerated storage room at the Spartanburg
funeral home her family hired to handle the
arrangements. The family paid to have her cremated.
Instead, her body was left to rot, draped in blankets
and surrounded by air fresheners to mask the smell,
the county coroner told them.
Fish and Fisheries Department Rots From the Top!
ATMs run dry as an economic system rots.

Rot in the system.
Counting ballots is so di cult in Florida.
My posts re ect my curiosity, awareness of dissonance
and experiential learning e orts . Glad you visit with
some interests.
Watch this: 2 minutes.
WHO acknowledged the picture of how antibiotics are
used around the world remains far from complete.
Monday's overview, for instance, includes only four
countries in Africa, three in the Middle East and six in
the Asia-Paci c region. Notably missing from the chart
are the United States, China and India.

The Northern Taurid meteor shower takes place on
Sunday, providing people around the world with the
chance to see a shooting star. While those in the
Southern Hemisphere may be put o by the ‘Northern’
part of the name, the good news is that the shower
should be visible to viewers in both hemispheres.
Here’s our guide to spotting a shooting star this
weekend.
"The launch may be visible, weather permitting, to
residents up and down the East Coast of the United
States," NASA said.
I am not convinced with the inferences this report
seeks to impress upon my mind. "The idea that private
schools do not increase a child’s chance of being
awarded more GCSEs and A-levels is not very credible,”
The system e ectively divided pupils into two types -
those destined for university and better jobs, and those
deemed more suitable for less celebrated professions.

The Dollars and Sense of Meaningful Work Our
Meaning and Purpose at Work report, released today,
surveyed the experience of workplace meaning among
2,285 American professionals, across 26 industries and
a range of pay levels, company sizes, and
demographics. The height of the price tag that workers
place on meaning should not be surprising - we are in
the experience economy.
While Hollywood movies and science ction novels
depict AI as human-like robots that take over the world,
the current evolution of AI technologies isn’t that scary
– or quite that smart. Instead, AI has evolved to provide
many speci c bene ts in every industry. Keep reading
for modern examples of arti cial intelligence in health
care, retail and more.
This week, she and another mother whose child died
under similar circumstances plan to travel to the o ce
of insulin maker Sano in Cambridge, Mass. They will
also be holding their children’s ashes.
“I would prefer to be able to get more done in a day,
but I’m going to accept what I’m realistically able to do.”
(This phrase utilizes a common cognitive-behavioral
therapy technique where it’s recommended people
swap out their “shoulds” for “prefer” or “could” in order
to relieve anxiety and feel more empowered).

Ethics is among the eld’s biggest challenges.
An example of “quali ed infectious disease product”
and subsequent “fast track” designations from the Food
and Drug Administration.

View Post Sunday November 11th, 2018
This story is part of a series by the BBC on
disinformation and fake news - a global problem
challenging the way we share information and perceive
the world around us. More stories published today: The
digital epidemic killing Indians How a fake news story
spreads Burned to death for rumours in Mexico Russia
and the fake news lab of death You can nd more
stories and more information about this series here.
Addicted to "growth".

System justi cation, like many other cognitive and
motivational processes, may operate outside of
conscious awareness. System justi cation theory began
as an account of stereotyping and intergroup relations,
before developing into an integrative framework that
could be applied to other topics. The term "system" is
used in the context of the theory to refer to any social,
economic, or political arrangements in which multiple
individuals (and/or groups) are embedded-ranging
from small-scale systems such as the nuclear family to
large-scale systems such as the nation-state or the
capitalist economy. By focusing on the ways in which
individuals accommodate and rationalize aspects of the
societal status quo, system justi cation theory com-
plements and expands upon several other social
psychological perspectives, including cognitive
dissonance, just world, social identity, terror man-
agement, social dominance, and shared reality
theories. Among other things, system justi cation
theory proposes that people actively defend and
bolster existing social arrangements, often by denying
or rationalizing injustices and other problems, even
when doing so comes at the expense of their personal
and group interests. Twenty years of system
justi cation theory: Introduction to the special issue on
“Ideology and system justi cation processes”

In 2004: A Decade of System Justi cation Theory:
Accumulated Evidence of Conscious and Unconscious
Bolstering of the Status Quo The evidence
demonstrates that people are motivated not only to
hold favorable attitudes toward themselves and toward
members of their own groups (as other theories
assume), but also to hold favorable attitudes toward
the existing social system and the status quo. What is
especially signi cant is that system justi cation motives
are sometimes capable of overriding ego and group
justi cation motives associated with the protection of
individual and collective interests and esteem. In
contrast to other theories, system justi cation theory
unambiguously addresses the possibilities that (a) there
is an ideological motive to justify the existing social
order, (b) the motive is at least partially responsible for
outgroup favoritism and the internalization of
inferiority among members of disadvantaged groups,
(c) it is observed most readily at an implicit,
nonconscious level of awareness, and (d) paradoxically,
it is sometimes strongest among those who are most
disadvantaged by the social order. PDF version:
http://www.psych.nyu.edu/jost/Jost,%20Banaji,%20%26
%20Nosek%20(2004)%20A%20Decade%20of%20Syste
m%20Justi cati.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1467-
9221.2004.00402.x

They dedicate their lives to saving people yet each year
an estimated 400 doctors end their lives in the U.S.
alone - that's equal to two graduating classes.
According to the American Foundation for Suicide
Prevention, doctors have the highest rate of suicide
among all professions.
Physician suicide is not an isolated event that the
general population should be comfortable ignoring; it is
an epidemic that needs to be explored.
Each year, more than 1 million Americans will lose their
doctor to suicide. I was almost one of those doctors.

About 8% of our genome is composed of sequences
with viral origin, namely human Endogenous
Retroviruses (HERVs). This review summarizes the
involvement of HERVs and their products in innate
immune responses, describing how their intricate
interplay with the rst line of human defenses can
actively contribute either to the host protection or to
his damage, implying a subtle balance between the
persistence of HERV expression and the maintenance
of a basal immune alert. Keywords: HERV, endogenous
retroviruses, innate immunity, interferon, evolution,
autoimmunity, cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC613934
9/
The prospect that virus-like proteins could be the basis
for a novel form of cell-to-cell communication in the
brain could change our understanding of how
memories are made, according to Jason Shepherd, a
neuroscientist at University of Utah Health and senior
author of the study publishing in the journal Cell on Jan.
11

Memory gene acts like a virus: Two independent teams
of NIH-funded researchers discovered that the Arc gene
can package its genetic material in a virus-like shell for
delivery to nearby cells.NIH
While Arc is known to play a vital role in the brain’s
ability to store new information, little is known about
precisely how it works. In addition, previous studies had
detailed similarities between the Arc protein and
proteins found in certain viruses like HIV, but it was
unclear how those commonalities in uenced the
behavior of the Arc protein. The Neuronal Gene Arc
Encodes a Repurposed Retrotransposon Gag Protein
that Mediates Intercellular RNA Transfer: Cell
https://www.cell.com/cell/fulltext/S0092-
8674(17)31504-0

Mentorship is a two-way street — a relationship
between humans — and not a transaction. So don’t just
march up to people and ask them to advise you. Take
the time to develop genuine connections with those
you admire, and assist them whenever you can. Mentor
#1: The master of craft Mentor #2: The champion of
your cause Mentor #3: The copilot Mentor #4: The
anchor Mentor #5: The reverse mentor (you are a
mentor)
Narinder Singh Kapany was born on 31 October 1926 in
Moga, Punjab (north of India) to a wealthy Sikh family.
He studied physics at the University of Agra (India)
while working in a factory for the design and
manufacture of optical instruments, where he began to
be interested in the technological applications of the
theories he studied. After graduating in 1952, he moved
to London to study for a doctorate at the Imperial
College in London with the prestigious British physicist
Harold Hopkins, a researcher in the eld of optics.
Kapany sought to achieve a system that would allow
the use of light as a means of transmitting information,
picking up the baton from earlier celebrated scientists.
One of these was the Frenchman Claude Chappe, who
in the 18th century developed a kind of optical
telegraph, considered the rst attempt to use light as a
vehicle for the exchange of information. His idea was to
position towers facing each other but separated by
dozens of kilometres and to use mirrors to re ect
messages encoded in the form of light.
https://www.bbvaopenmind.com/en/the-indian-
physicist-who-bent-light/

In 1953 an Indian physicist Narinder Singh Kapany
designed and manufactured a glass wire capable of
transporting light, which he later coined bre optics, an
invention that has transformed all our lives.
Bias Is Bipartisan.
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Have you seen to the Solvay Hut? At 4,003 metres
(13,133 ft), it is the highest mountain hut owned by the
Swiss Alpine Club, but can be used only in case of
emergency. The Hörnli Hut lying on the same ridge is
the starting point of the normal route to the summit.
The Solvay Hut was built in 1915, 50 years after the rst
ascent of the Matterhorn which took place on the same
ridge. It o ers 10 beds and is equipped with a
radiotelephone. The hut was named after its founder
Ernest Solvay, a Belgian chemist and industrialist.
The Solvay Conference, founded by the Belgian
industrialist Ernest Solvay in 1912, was considered a
turning point in the world of physics. Located in
Brussels, the conferences were devoted to outstanding
preeminent open problems in both physics and
chemistry. The most famous conference was the
October 1927 Fifth Solvay International Conference on
Electrons and Photons, where the world’s most notable
physicists met to discuss the newly formulated
quantum theory. The leading gures were Albert
Einstein and Niels Bohr.

Put your thoughts on PAPER by your hands.
“The things you can do to support heart-heathy
rhythms are the things you’d do to support general
health and cardiovascular health,” says Johns Hopkins
expert Mark Anderson, M.D., Ph.D. “Live in moderation.
Get enough sleep. Control risk factors like
hypertension, diabetes and cholesterol. Engage in
regular physical activity. Don’t smoke or drink too much
alcohol. And eat a balanced diet.”
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The nation needs both liberals and conservatives to
debate rationally to nd the common ground - the
common sense and common cause.
For head of school Peter Hutton, unlearning means
“new ways to think in the face of established practices.”
Sunday's ceremony occurred in the same vicinity of the
Bastille Day celebrations in Paris last year but won't be
as overly militaristic It was intended to commemorate
the end of war and not the practice of it. Did this event
provide for a re ective pause? “The old demons are
rising again, ready to complete their task of chaos and
of death,” Macron said earlier today.
"What if Learning Were the Purpose of Education”
Boyatzis et al. (1995)

Intense competition — combined with the regulatory,
social and managerial demands placed on early- to
mid-career researchers — encourages dubious and
counterproductive research practices.
Small - beautiful and antifragile.
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1111

The use of "generic" in the article is not in the context
of "generic vs brand". While methotrexate may have
come up short in beating back heart disease,
preventive cardiologists are calling its failure a vote of
con dence in a more speci c interpretation of what’s
known as the in ammatory hypothesis. First proposed
25 years ago by Dr. Paul Ridker of Brigham and
Women’s Hospital, the theory holds that in ammation
causes atherosclerosis — hardening and narrowing of
arteries that carry oxygen-rich blood to the heart —
independent of “bad” cholesterol also clogging those
coronary arteries.
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Grandkids having fun in Delhi ‫؃‬
Experiencing the world and connecting with roots can
be exciting and perplexing. This generation will have to
solve problems we are creating with our irrationality.

News coverage of air pollution in Delhi and picture
released by NASA showing stubble burning in north
India. (Photo courtesy: NASA)
With seasonal crop residue burning, industrial and
vehicle emissions and calm winds persisting, a thick
layer of toxic smog settled over the national capital on
Saturday.
"There are no shortcuts. We have to control the source
of pollution, that is the most important part."

Grandkids at the Delhi Airport. Looks like custom face
mask to counter the still lingering pollution. Hope these
mask have a capacity to lter out at minimum microns
size particles. The challenge is posed by submicron or
nanoparticles.
Good vibrations! Is it all about vibrations? The type of
vibrations and, about shared vibrations?
The Kordylewski clouds are two dust clouds rst
observed by Polish astronomer Kazimierz Kordylewski
in 1961. They are situated at two of the Lagrange points
in Earth's orbit.

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Most navigation today relies on a global navigation
satellite system (GNSS), such as GPS, which sends and
receives signals from satellites orbiting the Earth. The
quantum accelerometer is a self-contained system that
does not rely on any external signals. This is particularly
important because satellite signals can become
unavailable due to blockages such as tall buildings, or
can be jammed, imitated or denied – preventing
accurate navigation. One day of denial of the satellite
service would cost the UK £1 billion.

Ghei D, Sane R (2018) Estimates of air pollution in Delhi
from the burning of recrackers during the festival of
Diwali. PLoS ONE 13(8): e0200371.
doi:10.1371/journal.pone.0200371 Editor: Krishna
Prasad Vadrevu, University of Maryland at College Park,
UNITED STATES Received: February 4, 2018; Accepted:
June 25, 2018; Published: August 13, 2018
Grandkids and kids in Istanbul. Now traveling to New
Delhi, India. Safe Journey.
The neurobiology of recalling an object from memory is
di erent from dreaming, and is di erent from
purposeful conscious imagining a novel object
(example: a pineapple on top of a dolphin). The latter
process is referred to as mental synthesis to distinguish
it from the simple recall and dreaming. Mental
synthesis is controlled by and completely dependent on
the intact lateral prefrontal cortex.

The neuroscience of imagination.
Wow - paranormal activities on TV and and local area
has increased signi cantly since my previous inquisitive
look. Modern technology "EVP" recording and what not.
A symptom of the Experience Economy or that "normal
is over" or is this the "new normal"?

Grandkids in Istanbul.
The man who views the world at 50 the same as he did
at 20 has wasted 30 years of his life. – Muhammad Ali
Precious privilege

Expanding access to OTC products a high priority.
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Procustean; or 2nd Order of Conciousness (imperialist)
tending towards 1st Order of Consciousness (impulse
control). How to maintain a higher Order of
Consciousness?
Analytical quality by design (AQbD) methodology quite
popular. I nd it odd to see QbD in titles of "research"
publications.

The spending on R&D in the top 40 countries totals
$2.11 trillion of the about $2.19 trillion worldwide that
goes into technological development and innovation.
Tra c issues in Frederick. The state needs to do what it
can to move up construction funding for the project to
widen and improve U.S. 15 between Interstate 70 and
Md. 26, County Executive Jan Gardner told Maryland
transportation o cials Thursday in Frederick.

Pirate uprising against the East India Company! A
‘colony of exploitation’ now global.
Large number streaming and binging on gory in new
Net ix movies.

Rising drug prices, industry pro ts, and patient access
to new cures have become polarizing issues as
healthcare moves to a value-based framework for
reimbursement. Will "price control" bring the "left" and
"right" to collaborate?
In short, it’s easy to think about the Middle East in
terms of a race to the bottom and as ground zero for
con ict, repression, and state failure. Pease Dil Se.

How can things be booming when average Americans
are treading water? The answer has to do with the way
economists think about the economy. In both their
formal models and their mental ones, economic
performance is divided into two very di erent
components — macro and micro. That divide has
seeped into popular language and punditry,
occasionally causing unnecessary confusion.
Measurement challenges. The 8 percent plus growth is
puzzling at a time when export growth is weak, farmers
say they are in distress and there isn’t data to show
enough jobs were created.

Would China invade Taiwan if the U.S. Navy sent a ship
to visit the democratic island, something that Congress
has called upon the Pentagon to do in 2018?
Lost in Baltimore ‫ل‬Was expecting delivery on 5th
November ‫أ‬ Why track it?

Leaders must create a no-blame culture. The most
e ective way to build a culture of transparency begins
with those in leadership positions. It is the
responsibility of the leadership team to develop an
atmosphere in which there is balanced accountability
and continuous improvement and this is everyone’s
shared duty. Leaders must lead by example.
Brain anatomy alterations associated with Social
Networking Site (SNS) addiction | Scienti c Reports A
springboard for the research community to be more
proactive regarding the understanding, detection,
prevention and treatment of technology addictions and
other “dark side” of technology use phenomena.
https://www.nature.com/articles/srep45064
Online forums such as “Opiates” advertise themselves
as harm reduction forums, but data show that these
forums instead have a small amount of harm reduction
information. Many posts glorify unsafe drug use. Sites
like these may represent an impediment to educating
patients with opiate use disorder on safe use and
e ective treatment.

This paper is rst to indicate that machine learning
approaches can be used to identify potential substance
use risk behavior, such as alcohol use, among social
media users.
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