A marine fish breeding centre is a complex facility. Because of its zootechnical characteristics, during the production season proper hatchery management requires uncommon skills and total dedication by well-trained personnel. Therefore, in designing a fish hatchery only those technical solutions that offer the best guarantees in terms of reliability, ease of use, production capacity, hygienic working conditions and cost effectiveness have to be used. Gross mistakes in design and/or construction can risk a full production season even before it is started. In addition, temporary solutions always carry the risk of far from optimal rearing conditions, leading to disease outbreaks in fish larvae. This second part of the manual deals with the principles and guidelines for the design and construction of a commercial hatchery for gilthead seabream and seabass. This chapter describes how to calculate the size of the hatchery and how to select the appropriate site. It also deals with the design of production facilities. The function and the selection of hatchery systems and technical equipment are also described, focusing on the most widely adopted technical solutions in Mediterranean hatcheries. Special attention is given to the description of the seawater intake, and to water distribution, recirculation and treatment systems, as they are among the most sensitive components of the hatchery.