distinguish between natural superdisintegrants and synthetic superdisintegrants refered from several papers and books.

1. Difference between two types of Superdisintegrants
Natural superdisintegrants Synthetic superdisintegrants
These superdisintegranting agents are
natural in origin and are preferred over
synthetic substances because they are
comparatively cheaper, abundantly
available, non-irritating and nontoxic in
nature.
Synthetic superdisintegrants are
frequently used in tablet formulations to
improve the rate and extent of tablet
disintegration thereby increasing the rate
of drug dissolution.
Merits:
1. Easy availability and cost
effectiveness
2. Eco friendliness and non-irritant
nature
3. Non-toxicity
4. Capable of multitude of chemical
modifications and biocompatible -
Compatible due to natural origin.
1. Effective in lower concentrations
than starch.
2. Less effect on compressibility and
flow ability.
3. More effective intragranularly.
Examples: Gellan gum, locust bean gum,
guar gum, mango peel pectin,etc
Examples: Croscarmellose sodium,
sodium starch glycolate , crosspovidone