2. Sr.No. Monoclonal antibodies Polyclonal antibodies
1 It has high reproducibility with
respect to specificity and avidity.
It has low reproducible with
respect to specificity and avidity.
2 It has antibody reactivity and titre
is high.
It has antibody reactivity and
titre is low.
3 It is composed of pure, single
molecular species.
It is composed of polyvalent
antibodies.
4 It is having specificity for only one
antigenic determinants.
It is having specificity for all the
determinants of an antigen.
5 Less chances of cross reactions. High chances and get easily cross
reacted.
6 It is having poor complement
fixation.
It is having best complement
fixation.
7 Preparation: by tissue culture Preparation : by horses and
humans (in vivo)
2
