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Prepared By:
BHANU BISWAS
M.Pharm(Quality Assurance)
Maharishi Markandeswar(Deemed To Be
University)
TABLET COATING
18 April 20181
 A tablet coating is a process of
covering over a tablet which is used
to mask the taste, make it easier to
swallow, or protect the active
medication inside.
18 April 20182
PURPOSE OF COATING
18 April 20183
 Protection against light, air and moisture.
 Protecting API against digestive fluids.
 Better identification of tablets.
 Avoid side-effects.
 Provides a delayed release of medication.
TYPES OF COATING
18 April 20184
There are mainly 3 types of coating
 Sugar Coating
 Film Coating
 Enteric Coating
1. SUGAR COATING
18 April 20185
 This involves application of sugar (sucrose)
based coating solution to the tablets.
 It is carried out in coating pans having variable
capacities and mounted at an angle of 40º
 The coating is water soluble and dissolves after
swallowing.
18 April 20186
 The sugar coating involves following steps:
i. Sealing iv. Finishing
ii. Sub coating v. Polishing
iii. Syruping
SEALING
18 April 20187
 The tablet core must be sealed, dried and free
from any residual solvents.
 It prevents moisture penetration into the tablet
core.
 Seal coating agents are Oleic acids, PEG-4000,
Alcohol, Methylene glycol.
SUB COATING
18 April 20188
 It is actual starting of coating process and acts as the
foundation for smoothening and polishing.
 Sub coating is applied to build up tablet size and to
form uniform edges.
 It increase the tablet weight from 50-100%
 Eg: Gum acacia, Corn syrup, Gelatine.
SYRUPING
18 April 20189
 It is done to cover the imperfections in the
tablet surface that is caused during sub coating
step.
 Eg: Colorant, Cane sugar powders, Calcium
carbonate, Corn starch.
POLISHING
18 April 201810
 The desired lustre to the tablet is obtained by
polishing.
 Tablets are polished in standard coating pans
by application of bees wax, paraffin wax or
warm solution of waxes in suitable volatile
solvents.
2. FILM COATING
18 April 201811
 This technique is more used as compared to sugar
coating.
 In this process there is deposition of a thin film of
polymer surrounding the tablet core.
 The film formed is very thin and it gives the
tablet a less weight and small size.
 Eg: HPMC (Hydroxy Propyl Methyle Cellulose),
EC (Ethyle Cellulose), HPC (Hydroxy Propyl
Cellulose), etc.
3. ENTERIC COATING
18 April 201812
 Enteric coated tablets have delayed release
features.
 They are designed to pass unchanged through
the stomach to the intestines where the tablets
disintegrates and allow drug dissolution and
absorption.
 Eg: Omeprazole, Aspirin,etc
MODE OF ACTION
18 April 201813
18 April 201814
1. Conventional Pan Coater
18 April 201815
 They have circular metal pan mounted at 40º
 They are of 8-60 inch diameter.
 They are rotated on its horizontal axis by a
motor.
PELLIGRINI COATING PAN
18 April 201816
18 April 201817
 Heated air is supplied by inlet air supply.
 Coating solutions are applied to tablets by
spraying the material on the rotating tablet bed.
 It produces even distribution of coating
solutions or suspensions.
 The inlet air are exhausted by means of ducts
through the front of the pan.
IMMERSION TUBE COATING PAN
18 April 201818
18 April 201819
 It consists of long tube with a spray nozzle at
its tip.
 Hot air as well as solution gets delivered
through this tube into the tablet bed.
 Drying air flows upward and exhausted
through duct.
 This is used for both sugar coating as well as
film coating tablets.
2. PERFORATED PAN SYSTEM
18 April 201820
 It is perforated or partially perforated drum.
 The coating solutions are applied to the surface
of the rotating bed of tablets through spray
nozzels which are present inside drum.
 Perforated pan coaters are efficient drying
systems with high coating capacity.
ACCELA-COTA PAN
18 April 201821
18 April 201822
 It consists of mixing blades.
 Dry air is directed into the pan to the tablet bed.
 The spray gun sprays the coating solution
evenly.
 Exhausted air moves out of the pan through the
suction shoe.
DRIA COATER PAN
18 April 201823
18 April 201824
 The dry air enters through hollow perforated
ribs located inside the periphery of the drums.
 The spray evenly sprays the coating solution as
the coating pan rotates.
 The drying air passes up through exhaust which
is present in the back of the pan.
3. FLUIDIZED BED SYSTEM
18 April 201825
18 April 201826
 The movement of the tablets is upward through
the centre of the chamber.
 Then they fall down towards the chamber wall,
re-enters the air stream at the bottom of the
chamber.
 Coating solutions are applied from a spray
nozzle which is located either at the top or
bottom of the chamber.
Tablet Coating

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Tablet Coating

  • 1. Prepared By: BHANU BISWAS M.Pharm(Quality Assurance) Maharishi Markandeswar(Deemed To Be University) TABLET COATING 18 April 20181
  • 2.  A tablet coating is a process of covering over a tablet which is used to mask the taste, make it easier to swallow, or protect the active medication inside. 18 April 20182
  • 3. PURPOSE OF COATING 18 April 20183  Protection against light, air and moisture.  Protecting API against digestive fluids.  Better identification of tablets.  Avoid side-effects.  Provides a delayed release of medication.
  • 4. TYPES OF COATING 18 April 20184 There are mainly 3 types of coating  Sugar Coating  Film Coating  Enteric Coating
  • 5. 1. SUGAR COATING 18 April 20185  This involves application of sugar (sucrose) based coating solution to the tablets.  It is carried out in coating pans having variable capacities and mounted at an angle of 40º  The coating is water soluble and dissolves after swallowing.
  • 6. 18 April 20186  The sugar coating involves following steps: i. Sealing iv. Finishing ii. Sub coating v. Polishing iii. Syruping
  • 7. SEALING 18 April 20187  The tablet core must be sealed, dried and free from any residual solvents.  It prevents moisture penetration into the tablet core.  Seal coating agents are Oleic acids, PEG-4000, Alcohol, Methylene glycol.
  • 8. SUB COATING 18 April 20188  It is actual starting of coating process and acts as the foundation for smoothening and polishing.  Sub coating is applied to build up tablet size and to form uniform edges.  It increase the tablet weight from 50-100%  Eg: Gum acacia, Corn syrup, Gelatine.
  • 9. SYRUPING 18 April 20189  It is done to cover the imperfections in the tablet surface that is caused during sub coating step.  Eg: Colorant, Cane sugar powders, Calcium carbonate, Corn starch.
  • 10. POLISHING 18 April 201810  The desired lustre to the tablet is obtained by polishing.  Tablets are polished in standard coating pans by application of bees wax, paraffin wax or warm solution of waxes in suitable volatile solvents.
  • 11. 2. FILM COATING 18 April 201811  This technique is more used as compared to sugar coating.  In this process there is deposition of a thin film of polymer surrounding the tablet core.  The film formed is very thin and it gives the tablet a less weight and small size.  Eg: HPMC (Hydroxy Propyl Methyle Cellulose), EC (Ethyle Cellulose), HPC (Hydroxy Propyl Cellulose), etc.
  • 12. 3. ENTERIC COATING 18 April 201812  Enteric coated tablets have delayed release features.  They are designed to pass unchanged through the stomach to the intestines where the tablets disintegrates and allow drug dissolution and absorption.  Eg: Omeprazole, Aspirin,etc
  • 13. MODE OF ACTION 18 April 201813
  • 15. 1. Conventional Pan Coater 18 April 201815  They have circular metal pan mounted at 40º  They are of 8-60 inch diameter.  They are rotated on its horizontal axis by a motor.
  • 17. 18 April 201817  Heated air is supplied by inlet air supply.  Coating solutions are applied to tablets by spraying the material on the rotating tablet bed.  It produces even distribution of coating solutions or suspensions.  The inlet air are exhausted by means of ducts through the front of the pan.
  • 18. IMMERSION TUBE COATING PAN 18 April 201818
  • 19. 18 April 201819  It consists of long tube with a spray nozzle at its tip.  Hot air as well as solution gets delivered through this tube into the tablet bed.  Drying air flows upward and exhausted through duct.  This is used for both sugar coating as well as film coating tablets.
  • 20. 2. PERFORATED PAN SYSTEM 18 April 201820  It is perforated or partially perforated drum.  The coating solutions are applied to the surface of the rotating bed of tablets through spray nozzels which are present inside drum.  Perforated pan coaters are efficient drying systems with high coating capacity.
  • 22. 18 April 201822  It consists of mixing blades.  Dry air is directed into the pan to the tablet bed.  The spray gun sprays the coating solution evenly.  Exhausted air moves out of the pan through the suction shoe.
  • 23. DRIA COATER PAN 18 April 201823
  • 24. 18 April 201824  The dry air enters through hollow perforated ribs located inside the periphery of the drums.  The spray evenly sprays the coating solution as the coating pan rotates.  The drying air passes up through exhaust which is present in the back of the pan.
  • 25. 3. FLUIDIZED BED SYSTEM 18 April 201825
  • 26. 18 April 201826  The movement of the tablets is upward through the centre of the chamber.  Then they fall down towards the chamber wall, re-enters the air stream at the bottom of the chamber.  Coating solutions are applied from a spray nozzle which is located either at the top or bottom of the chamber.