This study evaluated the effectiveness of cognitive analytic therapy (CAT) for a patient with histrionic personality disorder (HPD) using a single-case experimental design. Daily self-ratings on five variables related to HPD symptoms were collected over 357 days during the assessment phase, 24-session CAT treatment, and 6-month follow-up. Three of the five variables showed statistically significant reductions during treatment. Follow-up data indicated initial deterioration at termination but eventual recovery and maintenance of progress. Validated clinical measures also demonstrated clinically significant change in personality integration and reduced depression.