2. PROTEIN
Protein is the building material for all body
parts, such as muscle, brain, blood, skin, hair,
nails, bones and body fluids.
Protein constitutes 20% of adult body weight.
Proteins are soluble in water
Proteins are made up of carbon, hydrogen,
oxygen, and nitrogen atoms that are formed
into basic units called amino acids.
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3. FUNCTIONS OF PROTEIN
Growth and development of body
Acts as Building blocks of cells and tissues
Formation of hemoglobin and anti-coagulant
factors
Regulates muscle contraction
Synthesis of enzyme, hormones and other
secretions
Produces digestive juices and antibodies.
Act as a source of energy: 1 gm of protein gives 4
kcal.
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4. SOURCES OF PROTEINS
There are 2 main
sources of protein
1. Animal sources:
Milk,
eggs, meat, fish,
cheese etc.
2. Plant sources:
Pulses,
cereals, beans. nuts,
soya bean etc.
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6. SIMPLE PROTEINS
Simple proteins are made up of amino acids
only.
On hydrolysis, they yield only amino acids
E.g. human plasma albumin, trypsin,
chymotripsin, pepsin, insulin, etc.
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7. CONJUGATED PROTEINS
They are proteins containing non protein part is
attached to protein part.
Conjugated protein – protein + prosthetic group
E.g. Lipoproteins: proteins combined with lipid
Glycoproteins: proteins combined with carbhydrate
phosphoproteins: proteins combined with
phosphate
Metaloproteins: proteins combined with metals
Nucleoproteins: Proteins combined with nucleic
acids
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8. DERIVED PROTEINS
They are proteins that derived from simple and
conjugated proteins.
Derived protein is of two types
1. Primary derived protein: formed from natural
proteins by the action of heat or alcohol, etc. E.g
albumin from cooked eggs.
2. Secondary derived protein: formed from partial
hydrolysis of protein. E.g proteaoses, peptides,
peptone, gelatin, etc.
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9. CLASSIFICATION OF PROTEINS
.
Complete proteins: supplies all essential amino acids
Incomplete proteins: lack some essential amino acids
Complete proteins Incomplete proteins
Legumes
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10. AMINO ACID
Amino acids are building blocks of protein and
derived from animals, plants or microbial
proteins.
There are 20 different amino acids. Nine of them
are essential, and the other eleven amino acids
can be produced by the body
Amino acids are end product of protein
digestion which is easily absorbable to blood
vessels for metabolism by liver from small
intestine by active transport mechanism.
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12. ESSENTIAL AMINO ACID
Not synthesized in
human body
Provided to body
through diet
@ PVTTIMHALL
P – phenylanine
V – valine
T – Threonine
T – Tryptophan
I – Isoleucine
M – Methionine
H – Histidine
A – Arginine
L – Leucine
L – Lysine
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13. SEMI-ESSENTIAL AMINO ACID
Not synthesized by
body in sufficient
quantity during growth
Obtained from diet for
growth of body
Needed for growth of
children and pregnant
mother
Also called growth
promoting factor
Includes argenine and
histidine
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14. NON- ESSENTIAL AMINO ACID
Synthesized in the
body
Synthesized from
essential amino acids
The most simple
amino acid is glycine
Includes
Proline
Cysteine
Asparagine
Glycine
Serine
Asparatic acid
Glutamic acid
Glutamine
Alanine
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15. DAILY REQUIREMENTS
Infants <6 months 2 gm/day
Infants 6-12 months 1.5 gm/day
Child 1-3 years 21 gm/day
Child 4-6 years 29 gm/day
Child 7-9 years 40 gm/day
Adolescents 13-15yrs Boys 67 gm/day
Adolescents 13-15yrs girls 62 gm/day
Adolescents 16-18yrs Boys 75 gm/day
Adolescents 16-18yrs girls 60 gm/day
Man 60 gm/day
Woman 50 gm/day
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16. PROTEIN DEFICIENCY
Acute ARI
Diarrhea
Skin changes
Anemia
Slow growth
Digestive problems
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17. BIOMEDICAL IMPORTANCE OF PROTEINS
1. Transportation of substance in the body. E.g
Hemoglobin
2. Immune production. E.g. antibodies
3. Biocatalysts in metabolic pathways.
E.g Enzymes
4. Muscle contraction. E.g muscle proteins
5. Control of gene expression and translation. E.g
histones.
6. Storage. E.g casein of milk
7. Control of many biochemical events. E.g hormones
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18. BIOMEDICAL IMPORTANCE OF PROTEINS
8. Proteins act as buffer. E.g plasma proteins
9. provides structural strength and elasticity to the
organ and vascular system. E.g collagen and elastin.
10. Nerve impulse generation and transmission. E.g
receptors
11. Acts as antivitamins. E.g avidin
12. Some toxins are proteins. E.g Enterotoxins
13. Functions as infective agents. E.g prions of virus
14. Components of structures of tissues. E.g -keratin
15. Control of growth differentiation. E.g promoters.
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