monkey pox and history

1. Monkeypox
virus

2. Overview
• Organism
• History
• Transmission
• Disease in Humans
• Prevention and Control

3. The organism
• Double stranded DNA
• Orthopoxvirus
• Variola, cowpox, vaccinia, monkeypox
(Poxviridae),
• Congo Basin(3.6%), West Affrica(10.6%)
• 1958 first
• 2003 , 2017-2019, 2022

4. History Of Smallpox
• First appeared in Northeastern Africa
around 10,000 BC
• Skin lesions on mummies
• 1570-1085 BC
• Ramses V

5. Inoculation
• 1000 China
• 1500 India
• 1715, Lady Mary Wortley Montague
• 1718, Inoculated her 5 yr. old son
• 1721, inoculated her daughter
• 1767 Dimsdale Thomas
https://quod.lib.umich.edu/e/evans/N09438
.0001.001?view=toc

6. Vaccine
• 1796 Edward Jenner
• Variolae Vacinate
• Vacca = cow
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7. The end of smallpox
• Last case of Variola major, Bangladesh 1975
• Oct. 26, 1977, Last case of Variola minor, Somalia
• May 8, 1980, official declaration by WHO - Smallpox
Eradicated!
• 1961 last case in Thailand
• 1980 last vaccine in Thailand

8. Transmission
• Person-to-person
• Direct contact With infected
body fluids
• Contaminated objects (Bedding,
clothing, bandages)
• Aerosol (rarely)

10. Prevention
& Treatment
• 85%
• no vaccine
• Tecovirimat ST-246
• Cidofovir