Monkeypox virus is an orthopoxvirus that causes a disease with symptoms similar to smallpox in humans and other primates. It primarily occurs in Central and West Africa in proximity to tropical rainforests. There are two distinct genetic clades - the Central African (Congo Basin) clade which historically causes more severe disease, and the West African clade. Various species of rodents and non-human primates serve as natural hosts. While its natural history is still uncertain, monkeypox was first identified in humans in 1970 in the Democratic Republic of Congo and has since been reported in several other Central and West African countries.

1. Monkey pox virus
L.Raghad Ibrahim

2. Introduction
• Monkeypox: is a viral zoonosis (a virus transmitted to humans
from animals) with symptoms very similar to those seen in the
past in smallpox patients, although it is clinically less severe.
With the eradication of smallpox in 1980 and subsequent
cessation of smallpox vaccination,
• monkeypox has emerged as the most important orthopoxvirus
for public health. Monkeypox primarily occurs in Central and
West Africa, often in proximity to tropical rainforests and has
been increasingly appearing in urban areas.
• Animal hosts include a range of rodents and non-human
primates.

3. The pathogen
• Monkeypox virus is an enveloped double-stranded DNA virus
that belongs to the Orthopoxvirus genus of the Poxviridae family.
There are two distinct genetic clades of the monkeypox virus –
the Central African (Congo Basin) clade and the West African
clade.
• The Congo Basin clade has historically caused more severe
disease and was thought to be more transmissible. The
geographical division between the two clades has so far been in
Cameroon - the only country where both virus clades have been
found.

4. Natural host of monkeypox virus
• Various animal species have been identified as susceptible to monkeypox
virus. This includes
• rope squirrels,
• tree squirrels,
• Gambian pouched rats
• dormice,
• non-human primates and other species.
• Uncertainty remains on the natural history of monkeypox virus and further
studies are needed to identify the exact reservoir(s) and how virus
circulation is maintained in nature.

5. Natural host of monkeypox virus
• Human monkeypox was first identified in humans in 1970 in the Democratic
Republic of the Congo in a 9-year-old boy in a region where smallpox had been
eliminated in 1968. Since then, most cases have been reported from rural,
rainforest regions of the Congo Basin, particularly in the Democratic Republic of
the Congo and human cases have increasingly been reported from across
Central and West Africa.
Since 1970, human cases of monkeypox have been reported in 11 African
countries – Benin, Cameroon, the Central African Republic, the Democratic
Republic of the Congo, Gabon, Cote d’Ivoire, Liberia, Nigeria, the Republic of the
Congo, Sierra Leone, and South Sudan. The true burden of monkeypox is not
known. For example, in 1996–97, an outbreak was reported in the Democratic
Republic of the Congo with a lower case fatality ratio and a higher attack rate
than usual. A concurrent outbreak of chickenpox

6. • caused by the varicella virus, which is not an orthoopoxvirus) and monkeypox was found which could
explain real or apparent changes in transmission dynamics in this case. Since 2017, Nigeria has
experienced a large outbreak, with over 500 suspected cases and over 200 confirmed cases and a case
fatality ratio of approximately 3%. Cases continue to be reported until today. Monkeypox is a disease of
global public health importance as it not only affects countries in West and Central Africa, but the rest of the world. In
2003, the first monkeypox outbreak outside of Africa was in the United States of America and was linked to contact with
infected pet prairie dogs. These pets had been housed with Gambian pouched rats and dormice that had been imported
into the country from Ghana. This outbreak led to over 70 cases of monkeypox in the U.S. Monkeypox has also been
reported in travelers from Nigeria to Israel in September 2018, to the United Kingdom in September 2018, December
2019, May 2021 and May 2022, to Singapore in May 2019, and to the United States of America in July and November
2021. In May 2022, multiple cases of monkeypox were identified in several non-endemic countries. Studies are
currently underway to further understand the epidemiology, sources of infection, and transmission patterns.