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Monkeypox
virus
Overview
• Organism
• History
• Transmission
• Disease in Humans
• Prevention and Control
The organism
• Double stranded DNA
• Orthopoxvirus
• Variola, cowpox, vaccinia, monkeypox
(Poxviridae),
• Congo Basin(3.6%), West Affrica(10.6%)
• 1958 first
• 2003 , 2017-2019, 2022
History Of Smallpox
• First appeared in Northeastern Africa
around 10,000 BC
• Skin lesions on mummies
• 1570-1085 BC
• Ramses V
Inoculation
• 1000 China
• 1500 India
• 1715, Lady Mary Wortley Montague
• 1718, Inoculated her 5 yr. old son
• 1721, inoculated her daughter
• 1767 Dimsdale Thomas
https://quod.lib.umich.edu/e/evans/N09438
.0001.001?view=toc
Vaccine
• 1796 Edward Jenner
• Variolae Vacinate
• Vacca = cow
รูปถ่ายนี้ โดย ไม่ทราบผู้เขียน ลิขสิทธิ์ของ CC BY-NC-ND
The end of smallpox
• Last case of Variola major, Bangladesh 1975
• Oct. 26, 1977, Last case of Variola minor, Somalia
• May 8, 1980, official declaration by WHO - Smallpox
Eradicated!
• 1961 last case in Thailand
• 1980 last vaccine in Thailand
Transmission
• Person-to-person
• Direct contact With infected
body fluids
• Contaminated objects (Bedding,
clothing, bandages)
• Aerosol (rarely)
Prevention
& Treatment
• 85%
• no vaccine
• Tecovirimat ST-246
• Cidofovir
monkeypox.pptx

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monkeypox.pptx

  • 2. Overview • Organism • History • Transmission • Disease in Humans • Prevention and Control
  • 3. The organism • Double stranded DNA • Orthopoxvirus • Variola, cowpox, vaccinia, monkeypox (Poxviridae), • Congo Basin(3.6%), West Affrica(10.6%) • 1958 first • 2003 , 2017-2019, 2022
  • 4. History Of Smallpox • First appeared in Northeastern Africa around 10,000 BC • Skin lesions on mummies • 1570-1085 BC • Ramses V
  • 5. Inoculation • 1000 China • 1500 India • 1715, Lady Mary Wortley Montague • 1718, Inoculated her 5 yr. old son • 1721, inoculated her daughter • 1767 Dimsdale Thomas https://quod.lib.umich.edu/e/evans/N09438 .0001.001?view=toc
  • 6. Vaccine • 1796 Edward Jenner • Variolae Vacinate • Vacca = cow รูปถ่ายนี้ โดย ไม่ทราบผู้เขียน ลิขสิทธิ์ของ CC BY-NC-ND
  • 7. The end of smallpox • Last case of Variola major, Bangladesh 1975 • Oct. 26, 1977, Last case of Variola minor, Somalia • May 8, 1980, official declaration by WHO - Smallpox Eradicated! • 1961 last case in Thailand • 1980 last vaccine in Thailand
  • 8. Transmission • Person-to-person • Direct contact With infected body fluids • Contaminated objects (Bedding, clothing, bandages) • Aerosol (rarely)
  • 9.
  • 10. Prevention & Treatment • 85% • no vaccine • Tecovirimat ST-246 • Cidofovir