This presentation discusses in vivo carcinogenicity studies, including their principles, methods, and procedures. Carcinogenicity studies involve administering test substances to experimental animals over their lifetimes to observe for evidence of cancer development. The presentation describes the study design, which involves exposing test animals to various doses of substances over their lifetime and monitoring for tumors. Key steps include selecting suitable animal models, administering the test substance via routes similar to human exposure, monitoring animals over their lifetimes, and performing detailed examinations to identify any potential cancers.