THE CARDIOVASCULAR AGENTS INCLUDES THE DETAIL INTRODUCTION TO THE TERM CARDIOVASCULAR AGENTS WITH CLASSFICATION AND DETAIL ACCOUNT ON STATINS.

1. CARDIOVASCULAR AGENTS
LOVASTATIN
SHIKHA POPALI
HARSHPAL SINGH WAHI
GURUNANAK COLLEGE OF PHARMACY, NAGPUR

2. WHAT IS CARDIOVASCULAR AGENTS
?
 CARDIOVASCULAR DRUGS REFERS TO PRESCRIPTION
DRUGS AND MEDICINE FOR DISEASES RELATING TO THE
STRUCTURE AND FUNCTION OF THE HEART AND BLOOD
VESSELS.
 THE CARDIOVASCULAR AGENTS USED IN THE TREATMENT
OF HEART FAILURE, CORONARY ARTERY DISEASES, HIGH
CHOLESTEROL, BLOOD CLOTS, CIRCULATION DISORDERS
AND OTHERS.

3. CLASSIFICATION OF
CARDIOVASCULAR AGENTS
 ANTIHYPERTENSIVE DRUGS
 ANTIANGINAL DRUGS
 CONGESTIVE HEART FAILURE DRUGS
 ANTIARRYTHMIC DRUGS
 DIURETICS DRUGS
 ANTITHROMBOTICS DRUGS
 ANTIHYPERLIPIDEMICS DRUGS

4. HYPERLIPIDEMIC DRUGS OR
HYPOLIPIDEMIC AGENTS
 These are drugs which lower the levels of lipids
and lipoproteins in blood
 The hypolipidaemic drugs have attracted
considerable attention because of their
potential to prevent cardiovascular disease by
retarding the accelerated atherosclerosis in
hyperlipidaemic individuals

5. HMG-COA REDUCTASE INHIBITORS
(STATINS)
 Introduced in the 1980s, this class of compounds
are the most efficacious and best tolerated
hypolipidaemic drugs
 They competitively inhibit Conversion of 3-
Hydroxy-3-methyl glutaryl coenzyme A (HMG-
CoA) to mevalonate (rate limiting step in CH
synthesis) by the enzyme HMG-CoA reductase

6. LOVASTATIN
 It is the first clinically used statin
 lovastatin which is mainly produced by
Aspergillus terreus strains is an inhibitor of
HMG-CoA reductase
 The mechanism of action is lovastatin decrease
or reduce the choleserol synthesis by inhibition
of rate limiting HMG-CoA reuctase

7. STRUCTURE OF LOVASTATIN
LOVASTATIN

8. SAR OF LOVASTATIN

11. LOVASTATIN DERIVATIVES:-
(PRAVASTATIN, SIMVASTATIN, MEVASTATIN)
 Pravastatin and Simvastatin chemically modified derivatives of
Lovastatin
 This derivatives are modified for improvements the actions of
lovastatin