THE DCC I.E. DICYCLOCARBODIIMDE IS A REAGENT AND HERE THE DETAIL ACCOUNT ON IT IS GIVEN INCLUDING MOLECULAR WEIGHT, STRUCTURE, SYNTHESIS AND PHYSICAL PARAMETERS AND APPLICATIONS FOR OTERS SYNTHESIS ARE ALSO DISCUSSED, THE DIFFERENT SYNTHESIS WITH DCC COMBINATION ARE ALSO MENTIONED

1. DI CYCLO HEXYL
CARBODIMIDE
(DCC)

2. DICYCLOHEXYLCARBODIMIDE
(C13H22N2)
• N,N’-Dicyclohexylcarbodimide is an organic
compound
• The important use to couple amino acids
during artificial peptide synthesis
• The compound is abbreviated as DCC, DCCD or
DCCI

3. PROPERTIES
• Under standard condition, it exists in the from
of white crystals with a heavy, sweet odor.
• The low melting point (30-350C)
• Boiling point 122-1240C
• Soluble in tetrahydrofuran, acetonitrile and
dimethylformamide dichloromethane, but
insoluble in water stable, but moisture
sensitive.

4. SAFETY PRECAUTION
• DCC is a potent allergen and a sensitizer, and
causing skin rashes.

6. SYNTHESIS
• It can also be prepared by oxidation of
dicyclohexylurea with p-toluene sulfonyl chloride in
hot pyridine or by heating dicyclohexylthiourea with
yellow mercuric oxide

7. APPLICATION
1. MOFFATT OXIDATION
• Moffatt oxidation is the oxidation of primary and secondary
alcohol in presence of dimethyl sulfoxide (DMSO) and
dicychexylcarbodimide (DCC) To form a alkoxysulfonium ylide
intermediate, which rearranges to from aldehydes and
ketones

9. MECHANISM
• Dicyclohexyl carbodiimide (1) is attacked by
dimethyl sulfoxide to from an intermediate (2)
• It is then promotated by the addition of the
alcohol oxygen on the sulfur atom
• Then a stable dicyclohexyl urea (4) is formed
along with sulfenate salt (3)
• It then react with a dihydeogen
phosphateanion to from ketone

12. THANK YOU