Pharmacology of antifungal agents

1. BY:- Shailja Sharma
M.Pharm
(Pharmacology)

2. OVERVIEW
• INTRODUCTION
• SYSTEMIC FUNGAL INFECTONS
• CELLULAR STRUCTURE FUNGI
• CLASSIFICATION OF ANTIFUNGAL
- BASED ON MECHANISM OF ACTION
- BASED ON STRUCTURE
• AMPHOTERICIN B
- MECHANISM OF ACTION
- ANTIFUNGAL SPECTRUM
- DRUG RESISTANCE
- ADMINISTRATION & DOSE
- PHARMACOKINECTICS
- SIDE EFFECTS
- THERAPEUTIC USES
- ADVERSE EFFECTS

3. FUNGUS -These are the eukaryotic, saprophytic, parasitic
and unicellular or multicellular , devoid of chlorophyll.

4. Cellular Structure:- Fungi

5. Classification :- Antifungal Agents
(mechanism of action)

6. Classification based on structure

8. AMPHOTERICIN B

9. Mechanism of action

12. Resistance of drug

15. SIDE EFFECTS
• Nephrotoxicity
• Flushing
• Anorexia
• Hypotension
• Hypopotasemia
• Anemia
• Hepatic dysfunction

16. THERAPEUTIC USES

17. ADVERSE EFFECTS

18. THANK YOU