IN THIS PPT GIVES VARIOUS TYPES OF SOLUBILITY IMPROVING METHODS.

1. PREPARED BY :
Mr. Santu S. Mistree
M-Pharm (P’ceutics)
P.Wadhwani college of Pharmacy
Yavatmal (MH)

2. CONTENT’S
 Definition of Solubility
 Need of Solubility
 Classification of Solubility Enhancement Technique’s
 References

3. Definition of solubility..
In quantitative terms, it may be defined as the concentration
of the solute in a saturated solution at a certain temperature.
OR
In qualitative terms, the spontaneous interaction of two or
more substances to form a homogeneous molecular
dispersion.
The solubility may be expressed as parts, percentage,
molarity, molality, volume fraction, and mole fraction.

4. Need of solubility…
 Drug absorption from the GIT is a most important process
for getting therapeutic effect BUT
 Its limited by various factors like poor aqueous solubility
and permeability of drug molecules.
 After orall administration of drug, it first dissolved in GI
fluids or intestinal fluids, prior to permeation through GI
membrane in order to reach systemic circulation.
 Therefore, to enhance bioavailabilty of active agents, the
p’ceutical researcher focus on two area include enhancing
solubility and dissolution rate of poorly water soluble drugs.

5. Classification of Solubility Enhancement Techniques..
The solubility enhancement technique are classified as per
following way,
A) Chemical Modifications:
 Salt Formation
 Co-crystallization
 Co-solvency
 Hydrotropy
 Use of novel solubilizer
 Nanotechnology

6. B) Physical Modifications:
B-1) Particle size reduction:
 Conventional method
 Micronization
 Nanosuspension
B-2) Modification of the crystal habit:
 Polymorphs
 Pseudo polymorphs
B-3) Complexation:
 Physical mixture
 Kneading method
 Co-precipitate method

7. B-4) Inclusion Complex Formulation Based
Techniques:
 Kneading method
 Lyophilization/ Freeze- drying Technique
 Microwave irradiation method
B-5) Solubilization by surfactants:
 Micro emulsions
 Self-micro emulsifying drug delivery system
B-6) Drug dispersion in carriers:
B-6-a) Solid solutions:
 Fusion Process
 Solvent Method

8.  Solvent Method
 Fusion solvent method
 Spray drying
 Lyophilization
 Hot melt Extrusion
 Dropping Method
C) PH Adjustment
D) Supercritical Fluid Process
E) Liquisolid Technique
F) Polymeric Alterssation

9. References..
1. Limbachiya M.I, Solubility enhancement techniques for
poorly soluble drugs: A review. IJPRD, 2011;4(4): 71-86
2. Patil MS, Godse SG, Saudagar RB. Solubility
Enhancement by Various Techniques: An overview. World
journal of pharmacy and pharmaceutical sciences. 2013;
2(6):4558-4572.
3. Kadam SV, Shinkar DM, Saudagar RB.,
Int.j.pharm.biol.sci. 2015,3 (3), 462-475.

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