It contain information about alternative names,advantages,disadvantages,type,equipment use for preparation,preparation method,factor affecting ,evaluation parameter and application etc.

1. Sir Dr. M. S. Gosavi College of Pharmaceutical
Education and Research, Nashik
MICROEMULSIONS
Prepared by-Mr.Kunal K. Shimpi
Industrial Pharmacy-II
Ty. B. Pharmacy
Roll No. :94
Division: B
Batch: E
Guided by – Mr. S. S. Boraste
M.Pharm. (Pharmaceutics)
Asst. Professor

2. Microemulsions are clear,
thermodynamically stable, isotropic liquid
mixtures of oil, water and surfactant,
frequently in combination with a
cosurfactant. The aqueous phase may
contain salt(s) and/or other ingredients,
and the “oil” may actually be a complex
mixture of different hydrocarbons and
olefins.

3. Altenative Name – Transparent Emulsion
Swollen Emulsions
Solubilized Oil
Micellar Solution
Composition Of Micro-Emulsions : Oil
Surfactant
Co-Surfactant
Water

5. Goals- 1.To Delivery Of hydrophilic as well as
lipophilic Drug As drug carriers because of it’s.
2.Improve drug solubilization capacity.
3.Long shelf life.
Advantage –
1.Increase the rate of absorption.
2. Increases the bioavailability.
3. helpful in test masking.
4.Eliminate variety in absorption.
5. Help in Solubilize lipophilic Drug.

6. Disadvantage –
1.Use of large of Surfactant and Co-Surfactant
Necessary for the Stabilizing Micro-Droplet.
2.limited solubilizing Capacity for High Melting
substances.
3. Micro emulsions stability Is enfluenced By
environmental Parameter such as Temperature
And pH . These parameter change Upon
microemulsion
delivery to The Patient.

7. Type of Microemulsions:-
1.O/W microemulsions
2. W/O microemulsion
3. Bi-continuousI microemulsions

8. Emulsions VS Micro-Emulsions :-

9. Equipment used for the
of microemulsion :-
1. Colloidal Mill
2. Homogenizer
3. Rotorstator
Preparation Method :-
1. Phase titration method
2. Phase inversion method

10. Phase Titration method -
A method, based on phase titration, for
analysis of ternary mixtures containing
mutually immiscible or partially miscible
components is described. The method
involves titrating a measured amount of
the sample at constant temperature with
one of the immiscible components to a
turbidimetric end-point.

11. Phase Inversion method –
Phase inversion of microemulsion occurs
on addition of dispersed phase or in
response to temperature. During phase
inversion physical changes occurs
including particle size change that can
affect drug release in vivo and in vitro.
These methods make use of changing the
curvature of the surfactant.

12. Factor Affecting Microemulsions-
1. Packing Ratio
2. Property of Surfactant
3. Property of Oil phase
4. Temperatures
5. Chain length
6. Nature of co-surfactant

13. Evaluation Parameter Studies:-
1. Phase behaviors
2. Size and shape
3. Rheology
4. Conductivity
5. Zeta potential
6. pH
7. Drug release studies
8. Physical Stability Study

14. Application :-
1. Oral delivery System
2. Parenteral delivery system
3. Opthalmic delivery system
4. Microemulsion in detergency
5. Microemulsion in Cosmetic
6. Microemulsion in food

15. Conclusion :-
1.The role of microemulsion in providing novel
solutions to overcome the problems of poor aqueous
solubility of highly lipophilic drug compounds and
provide high, more consistent and reproducible
bioavailability.
2. Microemulsions are having a vast and significant
potential in drug delivery as well as in the industrial
process.
3. Microemulsion in today’s world can be accepted as
full of potential in a novel drug delivery systems.

16. Thank You