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NDDS DOSAGE FORM
Submitted by:
Rhit Srivastava
Samridhi Shrigaur
(MBA-PHARMACEUTICAL
MANAGEMENT, BATCH 05)
THE IIHMR UNIVERSITY,
JAIPUR
 The conventional dosage form provide drug release for
immediately and it cause fluctuation of drug level In blood.
 Therefore to maintain the drug concentration in blood
within therapeutic effective range need noval drug delivery
systems.
WHY DO WE NEED NOVEL DRUGS
TYPES OF NOVAL DRUG DELIVERY SYSTEM
NOVAL
DRUG
DELIVERY
Oral drug
delivery
Inhalation /
pulmonary
drug delivery
system
Tans dermal
drug delivery
systemSpecializati
on drug
delivery
system
Injection
based
delivery
system
GI specific
delivery
ORAL DRUG DELIVERY SYSTEM
Formulation range from simple tablets to newest
modified tablets
Involves use of various forms of hydrogels, metrics
andpolymers.
Modification in oral NDDS based on:
Dissolution
Osmotic pressure
Microsphere based technology
Novel Packaging
•Dissolution and diffusion controlled system:
•Osmotic pressure controlled system
(Nefidipine)
VARIOUS TECHNOLOGY TO IMPROVE
BIOAVAILABILITY:
Micro cap delivery system(bio vail canada)
Micro pump delivery system( flamel tech, France)
Zeros tablet technology (switzerland)
Ceform micro sphere technology (fuisz technology ltd. , USA)
DPHS ( Delayed Pulsetile Hydrogel System): Andrex
pharmaceuticals
Dual release drug absorption system ( Elan Corporation)
Programmable Oral Drug Absorption System (elan corporation)
GI Specific drug release System
For sustain release of drug in GIT
Various approach to prolong GI residence time
-GAS generating system
-Super porous hydrogel
-Mucoadhesive systems
-Ex: Buccasartan
(buccal tablet , used for treatment of nausea and vomitting)
-Colon Targeted Drug delivery:
-in treatment of Colon
- hydrogels, prodrugs and coated dosage forms
basically preferred
INJECTABLE DRUG DELIVERY SYSTEM
Insulin Delivery : Insulin Pens Insulin Pumps
• Bone Marrow Injections (in chronic myocardial intra myocardial
injections of Autologous bone marrow cell)
Inhalational Drug Delivery System
• A bright Prospect for site specific Delivery of biotechnological
Products such as insulin and other hormones.
• Attractive For delicate molecule allowing systemic circulation
without significant degradation
Metered dose inhaler
Metered dose inhaler
. Dry powder inhaler
Inhalation solution & suspension (
nebulizer)
Inhalation Nasal Spray
Transdermal Delivery System
•Provides a leading edge over injectables and oral
routes by increasing.
•Controlled , constant administration of the drug , allows
continuous input of drugs with short biological half life.
•Transdermal Patches
•Micro needle patches : for improving the absorption of
drugs.
Various Technology Used
Coated Implantable Drug Delivery System
• Permits Localized Drug Delivery from implant.
• Best for prolonged duration
EXAMPLE :
Hormonal delivery to endometrium from intrauterine
device, sirolimus coated stents in coronary arteries.
Targeted Drug Delivery
 Monoclonal Antibodies: Bind with cancer specific antigen and
induce immunological response to cancer cell.
 Modify for delivery toxin, radioisotops, cytokine
or other active conjugatates.
LIPOSOMAL DRUG DELIVERY SYSTEM
Pre-clinical and clinical liposomal packed drug exhibit reduced
toxicities with enhanced efficacy,
Drug accumulation at diseased sites and reduced distribution
example: Amphotericin B antibiotics
Nano Particle Based Delivery system
• By using nana particle drug can be used at the precise location,
which would make the drug more effective.
• It reduces the toxicities , greater safety and biocompatibility.
EX: carbon nano tube: treatment of Bronchial Asthma, lung
toxicities
•Gold nano particle :used in
chemotherapy n
free radical generation
Application of Nanotechnology:
•Promising tool for advancement of drug delivery
•Nano shells that concentrate the heat from infrared light to
destroy cancer cell with minimal damage to surrounding healthy
cells
•Nanotubes used in broken tubes to provide a structure for new
bone material to grow.
•Nano particle in pulmonary drug delivery system.
Nano erythrosomes
 Erythrocytes based new carrier.
 Administered via iv or intra-arterial.
 Prepared by extrusions of erythrocyte
ghost to produce small vesicle.
Genetic Transfer system
 Gene transfer by several nano formulations
are still under formulations.
 Tow methods- viral or non viral gene transfer.
 Currently very few are in phase 3 trial.
Ndds

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Ndds

  • 1. NDDS DOSAGE FORM Submitted by: Rhit Srivastava Samridhi Shrigaur (MBA-PHARMACEUTICAL MANAGEMENT, BATCH 05) THE IIHMR UNIVERSITY, JAIPUR
  • 2.  The conventional dosage form provide drug release for immediately and it cause fluctuation of drug level In blood.  Therefore to maintain the drug concentration in blood within therapeutic effective range need noval drug delivery systems. WHY DO WE NEED NOVEL DRUGS
  • 3.
  • 4. TYPES OF NOVAL DRUG DELIVERY SYSTEM NOVAL DRUG DELIVERY Oral drug delivery Inhalation / pulmonary drug delivery system Tans dermal drug delivery systemSpecializati on drug delivery system Injection based delivery system GI specific delivery
  • 5. ORAL DRUG DELIVERY SYSTEM Formulation range from simple tablets to newest modified tablets Involves use of various forms of hydrogels, metrics andpolymers. Modification in oral NDDS based on: Dissolution Osmotic pressure Microsphere based technology Novel Packaging •Dissolution and diffusion controlled system: •Osmotic pressure controlled system (Nefidipine)
  • 6. VARIOUS TECHNOLOGY TO IMPROVE BIOAVAILABILITY: Micro cap delivery system(bio vail canada) Micro pump delivery system( flamel tech, France) Zeros tablet technology (switzerland) Ceform micro sphere technology (fuisz technology ltd. , USA) DPHS ( Delayed Pulsetile Hydrogel System): Andrex pharmaceuticals Dual release drug absorption system ( Elan Corporation) Programmable Oral Drug Absorption System (elan corporation)
  • 7. GI Specific drug release System For sustain release of drug in GIT Various approach to prolong GI residence time -GAS generating system -Super porous hydrogel -Mucoadhesive systems -Ex: Buccasartan (buccal tablet , used for treatment of nausea and vomitting) -Colon Targeted Drug delivery: -in treatment of Colon - hydrogels, prodrugs and coated dosage forms basically preferred
  • 8. INJECTABLE DRUG DELIVERY SYSTEM Insulin Delivery : Insulin Pens Insulin Pumps • Bone Marrow Injections (in chronic myocardial intra myocardial injections of Autologous bone marrow cell)
  • 9. Inhalational Drug Delivery System • A bright Prospect for site specific Delivery of biotechnological Products such as insulin and other hormones. • Attractive For delicate molecule allowing systemic circulation without significant degradation Metered dose inhaler Metered dose inhaler . Dry powder inhaler Inhalation solution & suspension ( nebulizer) Inhalation Nasal Spray
  • 10. Transdermal Delivery System •Provides a leading edge over injectables and oral routes by increasing. •Controlled , constant administration of the drug , allows continuous input of drugs with short biological half life. •Transdermal Patches •Micro needle patches : for improving the absorption of drugs.
  • 12. Coated Implantable Drug Delivery System • Permits Localized Drug Delivery from implant. • Best for prolonged duration EXAMPLE : Hormonal delivery to endometrium from intrauterine device, sirolimus coated stents in coronary arteries.
  • 13. Targeted Drug Delivery  Monoclonal Antibodies: Bind with cancer specific antigen and induce immunological response to cancer cell.  Modify for delivery toxin, radioisotops, cytokine or other active conjugatates.
  • 14. LIPOSOMAL DRUG DELIVERY SYSTEM Pre-clinical and clinical liposomal packed drug exhibit reduced toxicities with enhanced efficacy, Drug accumulation at diseased sites and reduced distribution example: Amphotericin B antibiotics
  • 15. Nano Particle Based Delivery system • By using nana particle drug can be used at the precise location, which would make the drug more effective. • It reduces the toxicities , greater safety and biocompatibility. EX: carbon nano tube: treatment of Bronchial Asthma, lung toxicities •Gold nano particle :used in chemotherapy n free radical generation
  • 16. Application of Nanotechnology: •Promising tool for advancement of drug delivery •Nano shells that concentrate the heat from infrared light to destroy cancer cell with minimal damage to surrounding healthy cells •Nanotubes used in broken tubes to provide a structure for new bone material to grow. •Nano particle in pulmonary drug delivery system.
  • 17. Nano erythrosomes  Erythrocytes based new carrier.  Administered via iv or intra-arterial.  Prepared by extrusions of erythrocyte ghost to produce small vesicle. Genetic Transfer system  Gene transfer by several nano formulations are still under formulations.  Tow methods- viral or non viral gene transfer.  Currently very few are in phase 3 trial.