Explain why conditions that cause destruction ibB lymphocytes and / or T lymphocytes cause malfunctioning of both the specific and nonspecific immune responses. Solution B lymphocytes are essential for formation of antibodies against foreign antigen found in the circulation. Where as The lymphocytes are essential to mediate the immune response strongly between cell mediate and humoral immunity systems. Here B cell regulates cell specific or antigen specific and T cells showing nonspecific immune response..