Obama's precise medication,mechanism of action of obesity,causes,treatment

2. • Medical treatments have been designed for
“average patients”
• Precision Medicine is an innovative approach
that takes into account individual differences
in people’s genes, environment, and
lifestyles
•As a result of this “one-size-fits-all”
approach, treatments are not successful for all

3. Abnormal accumulation of body fat

4. Just measure your weight in Kilograms (kg)
and your height in meters (m), and then use
this formula

5. Pre-opiomelanocortin
*MSH – Melanocyte Stimulating
Hormone
*
Melanocortin
4 Receptor

6.  Genetics
 Overeating
 Physical inactivity
 Medication
 Diseases
 Lack of sleep
 Social issues

7. • Leptin
•MC4R (Melanocortin 4 receptor)
• PCK1 (Phosphoenol pyruvate carboxylase 1)
• POMC ( Pre-opiomelanocortin)

8. Drugs Mechanism of
Action
Adverse Drug
Reaction
Orlistat Inhibit
pancreatic lipase
Gastrointestinal
side effects
Sibutramine Inhibit
norepinephrine &
Serotonin
Heart attack
Rimonabant Cannabinoid 1
receptor
antagonist
___
Metformin Decrease
production of
glucose from
pancreas
Impaired Renal
functions

9.  High blood pressure
 Heart disease
 Gallbladder disease
 Osteoarthritis
 High cholesterol and triglycerides