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DROPLET GENERATION USING MICROFLUIDIC SYSTEMS
- 1. DROPLET GENERATION USING MICROFLUIDIC SYSTEM Presented by: • Praveen Kumar (IBM2012011) • Suravi Srivastava (IBM2012014) • Saurabh Shivalkar (IBM2012022) • Divakar Badal (IBM2012031) • Amar Dhwaj (IBM2012035) • Mehul Agrawal (IBM2012036) Under Guidance: Dr. Amit Prabhakar Mid-Sem Project Evalualtion on
- 2. INTRODUCTION What is Micro-Fluidic system ? Where do we need them ? 400/100 T- junction having flow rate of 15microlt /min Tripathi S., Prabhakar A., Kumar N., Sing G.S. and Agarwal A ., ‘Blood plasma separation in elevated dimension T-shaped microchannel ‘ , Biomed microdevices , springer2013
- 3. Problem Statement & Objective • To build a cheaper microfluidic device for the generation of droplets on the simulated geometry of T & Y-junction.
- 4. Literature review • Mattias Björnmalm, Yan Yan, Frank Caruso,’Engineering and evaluating drug delivery particles in microfluidic devices’, Journal of Controlled Release, elsevier,2014 • Linas Mazutis, John Gilbert, W Lloyd Ung, David A Weitz, Andrew D Griffiths & John A Heyman,’ Single-cell analysis and sorting using droplet-based microfluidics’,Nature protocal 2013: • Zhao-Miao Liu, Li-Kun Liu and Feng Shen,’Effects of geometric configuration on droplet generation in Y-junctions and anti-Y-junctions microchannels’, Acta Mech. Sin.,Springer, Aug2015
- 5. Simulation Parameters Assumptions : 1) Noslip Boundry Conditions. 2) Laminar Fluid Flow 3) Incompressable Fluids 4) Uniform Pressure Distribution 5) Immiscible Fluids 6) Solid boundaries represent a wetted wall with a contact angle of 135 degrees .
- 6. Worked So far: At Flow rate : 0.4ml/min Continuous Fluid 0.4ml/min Dispersion Fluid For Duration: 0:0.005:0.08 sec Average droplet diameter: T-junction : 0.107948 mm Y-junction : 0.116021 mm
- 7. Contd... At Flow rate : 0.4ml/min Continuous Fluid 0.2ml/min Dispersion Fluid For Duration: 0:0.005:0.08 sec Average droplet diameter: T-junction : 0.077978 mm Y-junction : 0.091834 mm
- 8. Contd... At Flow rate : 0.3ml/min Continuous Fluid 0.1ml/min Dispersion Fluid For Duration: 0:0.005:0.08 sec Average droplet diameter: T-junction : 0.072818 mm Y-junction : 0.065366 mm
- 9. Contd... At Flow rate : 0.4ml/min Continuous Fluid 0.1ml/min Dispersion Fluid For Duration: 0:0.005:0.08 sec Average droplet diameter: T-junction : 0.043542 mm Y-junction : 0.061932 mm
- 11. Slide
- 13. Syringe Pump
- 15. Result
- 16. Future scope • Using such master slides, cheaper design testing can be achieve. • Verified designs can be rebuild using standard protocols.
- 17. Thank you
- 18. References • Mattias Björnmalm, Yan Yan, Frank Caruso,’Engineering and evaluating drug delivery particles in microfluidic devices’, Journal of Controlled Release, elsevier,2014 • Linas Mazutis, John Gilbert, W Lloyd Ung, David A Weitz, Andrew D Griffiths & John A Heyman,’ Single-cell analysis and sorting using droplet-based microfluidics’,Nature protocal 2013: • Zhao-Miao Liu, Li-Kun Liu and Feng Shen,’Effects of geometric configuration on droplet generation in Y- junctions and anti-Y-junctions microchannels’, Acta Mech. Sin.,Springer, Aug2015 • Comsol user manual https://www.comsol.co.in/model/download/220831/models.cfd.droplet_breakup.pdf
Editor's Notes
- At IIIT-Allahabad Under the esteemed guidance of Dr. Amit Prabhakar
- have dimensions ranging from millimeters (mm) down to micrometers that deal with volumes of fluid on the order of micro lit Tablet surface area/volume (SA/V) was a significant factor in controlling drug release from carbomer based tablets. Tablets with larger SA/V typically had faster release profiles, regardless of the dose or shape. So if we increase the SVR ... More treatment will get affecte
- Comprehensive analysis on Y-junctions and T-junction microchannels can lead to the conclusion that droplet size is bigger and the generation cycle is longer when the absolute angle increases.
- (1) It is found that droplets generated in anti-Y-junctions had smaller sizes and shorter generation cycles com- pared with those in Y-junctions under the same experi- mental conditions, and the vortex appearing in contin- uous phase in anti-Y-junctions is one of the key factors that lead to the difference. Smaller droplets can be obtained with the best effect on emulsifying and mixing through anti-Y-junction microchannels. (2) Comprehensive analysis on Y-junctions and anti-Y- junction microchannels can lead to the conclusion that droplet size is bigger and the generation cycle is longer when the absolute angle value of the intersec- tion between continuous and dispersed phases (i.e., the angle between main channel and continuous phase or dispersed phase channel) increases. (3) DropletssizeisinfluencedbyY-angle,whichvarieswith the channel depth in Y-junctions, but Y-angle always affects the droplet generation cycle, that is, the larger the Y-angle, the longer the generation cycle. However a smaller height-width ratio would enhance the impact of the two immiscible liquids intersection angle on the droplet generation cycle in Y-junction microchannels. (4) Partial differences exist in the velocity at the two immiscible liquids interface because of the influence of channel depth, which leads to different droplets sizes and formation cycles. When the microchannel depth decreases, the droplet size is significantly reduced and its generation period becomes larger.