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Biology Of Cancer
Submitted To - dr. monika asthana
submitted BY –
Prashant sharma
POOJA GUPTA
What is cancer?
Cancer is the abnormal proliferation of any of the different kind of cell.
Cancer- Latin word which means “Crab”
OncologyStudy of cancer
Onco- Greek word which means Tumor
Tumor
Tumor is uncontrolled growth of cell.
Types of Tumors
Types of Cancers
On the basis of cell type On the basis of tissue of origin
On the basis of cell type
On the basis of tissue of
origin
Fibro-sarcoma- in fibroblast
Erythoid leukemia- in RBC
Development of Cancer
Causes of Cancer
Radiations Chemicals Viruses
Tumor Viruses
Properties of Cancer Cells
 Less adhesive
 Secrete Proteases
 Angiogenesis
 Fail to undergo Apoptosis
 Loss of Density dependent inhibition
 Autocrine growth stimulation
 Loss of Contact Inhibition
 Defective Differentiation
Density Dependent Inhibition
Autocrine Growth Stimulation
Contact Inhibition
Defective Differentiation
Genes involved in Cancer
Oncogenes Tumor Suppressor
Genes
Oncogenes
Proto- oncogenes and oncogenes
Conversion of Proto-oncogenes
into oncogenes
Tumor Suppressor Genes
Role of p53 in cancer
Retino Blastoma
Treatment of Cancer
 By Surgery
 Chemotherapy
 Radiation therapy
 Immunotherapy
 Gene therapy
 Inhibiting the activity of cancer promoting
genes (Antisense approach)
 Inhibition of Angiogenesis
Immunotherapy
Gene therapy
Antisense approach
Inhibition of Angiogenesis
Prevention of cancer
Thank you!!
Any question???

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biology of cancer